Chemistry - A European Journal,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 10, 2024
Abstract
The
development
of
redox‐sensitive
molecular
fluorescent
probes
for
the
detection
redox
changes
in
Plasmodium
falciparum
‐parasitized
red
blood
cells
remains
interest
due
to
limitations
current
genetically
encoded
biosensors.
This
study
describes
design,
screening
and
synthesis
new
pro‐fluorophores
based
on
flavylium
azido
dyes
coupled
by
CuAAC
click
chemistry
alkynyl
analogues
plasmodione
oxide,
key
metabolite
potent
redox‐active
antimalarial
plasmodione.
photophysical
electrochemical
properties
these
were
evaluated,
focusing
their
fluorogenic
responses.
influence
both
status
quinone
length
PEG
chain
separating
fluorophore
from
electrophore
was
investigated.
fluorescence
quenching
photoinduced
electron
transfer
is
reversible
high
amplitude
oxidized
forms
reinstated
reduced
hydroquinone
forms.
Our
results
demonstrate
that
shortening
has
effect
enhancing
response,
likely
non‐covalent
interactions
between
two
chromophores.
All
systems
evaluated
antiparasitic
activities
imaging
suggests
efficacy
P.
cells,
paving
way
future
parasite
studies
monitor
cellular
processes.
Materials Chemistry Frontiers,
Год журнала:
2023,
Номер
8(4), С. 930 - 955
Опубликована: Дек. 7, 2023
This
review
mainly
summarizes
the
research
advances
in
synthetic
strategies,
optical
properties,
and
biomedical
applications
of
red-emissive
carbon
dots
recent
years.
Analytical Chemistry,
Год журнала:
2024,
Номер
96(18), С. 7138 - 7144
Опубликована: Апрель 27, 2024
Superoxide
anion
(O2·–)
and
peroxynitrite
(ONOO–),
two
important
oxidants
under
oxidative
stress,
coexist
in
complex
cell
organism
systems,
playing
crucial
roles
various
physiological
pathological
processes,
particularly
neurodegenerative
diseases.
Despite
the
absence
of
robust
molecular
tools
capable
simultaneously
visualizing
O2·–
ONOO–
biosystems,
relationship
between
these
species
remains
understudied.
Herein,
we
present
sequentially
activated
fluorescent
probe,
DHX-SP,
which
exhibits
exceptional
selectivity
sensitivity
toward
ONOO–.
This
probe
enables
precise
imaging
living
PC12
cells
stress
conditions
using
distinct
fluorescence
signal
combinations.
Furthermore,
DHX-SP
has
ability
to
visualize
changes
levels
during
ferroptosis
Parkinson's
disease
model.
These
findings
establish
a
connection
crosstalk
phosphorus
group
stress.
Analytical Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 21, 2025
Ferroptosis
is
a
type
of
cell
death
triggered
by
the
iron-dependent
accumulation
lipid
peroxides
in
cells.
Diabetes,
chronic
metabolic
disorder
characterized
hyperglycemia,
can
lead
to
various
health
complications.
The
process
ferroptosis
and
progression
diabetes
are
closely
linked
redox
homeostasis,
which
regulated
levels
reactive
oxygen
sulfur
species.
Currently,
there
no
fluorescent
probes
available
monitor
changes
homeostasis
during
diabetes.
Here,
we
report
first
endeavor
create
reversible
near-infrared
fluorogenic
(NIRF)
probe
for
monitoring
reversal
precise
diagnosis.
In
vitro
data
demonstrated
that
NIR-CSTe
could
cyclically
reversibly
detect
ONOO-
GSH
up
four
times
with
minimal
loss
fluorescence
intensity.
With
help
NIR-CSTe,
observed
HT-1080
cells,
induced
undergo
erastin
after
being
washed
PBS
24
h
then
treated
ferrostatin-1,
showed
recovery
intracellular
levels.
contrast,
treatment
deferoxamine
did
not
yield
similar
results.
Lastly,
was
also
utilized
early
diagnosis
efficacy
assessment
relation
ONOO-/GSH
balance,
results
illustrating
combined
administration
metformin
empagliflozin
more
effective
than
using
either
drug
alone.
Thus,
this
smart
holds
significant
potential
as
an
essential
tool
clinical
diseases
associated
homeostasis.
