Journal of the American Chemical Society,
Год журнала:
2024,
Номер
146(17), С. 12087 - 12099
Опубликована: Апрель 22, 2024
Electron
transfer
during
solid–liquid
contact
electrification
has
been
demonstrated
to
produce
reactive
oxygen
species
(ROS)
such
as
hydroxyl
radicals
(•OH)
and
superoxide
anion
(•O2–).
Here,
we
show
that
a
process
also
occurs
in
liquid–liquid
electrification.
By
preparing
perfluorocarbon
nanoemulsions
construct
perfluorocarbon–water
"liquid–liquid"
interface,
confirmed
electrons
were
transferred
from
water
ultrasonication-induced
high-frequency
•OH
•O2–.
The
produced
ROS
could
be
applied
ablate
tumors
by
triggering
large-scale
immunogenic
cell
death
tumor
cells,
promoting
dendritic
maturation
macrophage
polarization,
ultimately
activating
T
cell-mediated
antitumor
immune
response.
Importantly,
the
raw
material
for
producing
is
water,
so
therapy
not
limited
endogenous
substances
(O2,
H2O2,
etc.)
microenvironment.
This
work
provides
new
perspectives
elucidating
mechanism
of
generation
free
an
excellent
therapeutic
modality.
Nature Communications,
Год журнала:
2025,
Номер
16(1)
Опубликована: Янв. 11, 2025
Hypoxic
tumors
present
a
significant
challenge
in
cancer
therapy
due
to
their
ability
adaptation
low-oxygen
environments,
which
supports
tumor
survival
and
resistance
treatment.
Enhanced
mitophagy,
the
selective
degradation
of
mitochondria
by
autophagy,
is
crucial
mechanism
that
helps
sustain
cellular
homeostasis
hypoxic
tumors.
In
this
study,
we
develop
an
azocalix[4]arene-modified
supramolecular
albumin
nanoparticle,
co-delivers
hydroxychloroquine
mitochondria-targeting
photosensitizer,
designed
induce
cascaded
oxidative
stress
regulating
mitophagy
for
treatment
These
nanoparticles
are
hypoxia-responsive
release
loaded
guest
molecules
cells.
The
released
disrupts
process,
thereby
increasing
further
weakening
Additionally,
upon
laser
irradiation,
photosensitizer
generates
reactive
oxygen
species
independent
oxygen,
inducing
damage
activation.
dual
action
simultaneous
spatiotemporal
activation
flux
blockade
results
enhanced
autophagic
stress,
ultimately
driving
cell
death.
Our
work
highlights
effectiveness
hydroxychloroquine-mediated
combined
with
mitochondria-targeted
cascade-amplified
against
has
been
recognized
as
Here,
group
fabricates
nanoparticle
codelivering
(HCQ)
sulfur-substituted
methylated
nile
blue
analog,
capable
via
Advanced Materials,
Год журнала:
2024,
Номер
36(31)
Опубликована: Май 19, 2024
The
emergence
of
multidrug
resistant
(MDR)
pathogens
and
the
scarcity
new
potent
antibiotics
antifungals
are
one
biggest
threats
to
human
health.
Antimicrobial
photodynamic
therapy
(aPDT)
combines
light
photosensitizers
kill
drug-resistant
pathogens;
however,
there
limited
materials
that
can
effectively
ablate
different
classes
infective
pathogens.
In
present
work,
a
class
benzodiazole-paired
is
designed
as
highly
PDT
agents
with
broad-spectrum
antimicrobial
activity
upon
illumination
nontoxic
light.
results
mechanistically
demonstrate
energy
transfer
electron
between
nonphotosensitive
photosensitive
benzodiazole
moieties
embedded
within
pathogen-binding
peptide
sequences
result
in
increased
singlet
oxygen
generation
enhanced
phototoxicity.
Chemical
optimization
renders
PEP3
novel
agent
remarkable
against
MDR
bacteria
fungi
well
at
stages
development
(e.g.,
biofilms,
spores,
fungal
hyphae),
which
also
prove
effective
an
ex
vivo
porcine
model
microbial
keratitis.
chemical
modularity
this
strategy
its
general
compatibility
peptide-based
targeting
will
accelerate
design
for
PDT.
Materials Today Bio,
Год журнала:
2024,
Номер
26, С. 101027 - 101027
Опубликована: Март 16, 2024
Multimodal
imaging,
which
combines
the
strengths
of
two
or
more
imaging
modalities
to
provide
complementary
anatomical
and
molecular
information,
has
emerged
as
a
robust
technology
for
enhancing
diagnostic
sensitivity
accuracy,
well
improving
treatment
monitoring.
Moreover,
application
multimodal
in
guiding
precision
tumor
can
prevent
under-
over-treatment,
thereby
maximizing
benefits
patients.
In
recent
years,
several
intriguing
magneto-optical
nanosystems
with
both
magnetic
optical
properties
have
been
developed,
leading
significant
breakthroughs
field
image-guided
therapy.
These
advancements
pave
way
precise
medicine.
This
review
summarizes
various
types
developed
recently
describes
their
applications
probes
agents
therapeutic
interventions.
Finally,
future
research
development
prospects
are
discussed
along
an
outlook
on
further
biomedical
field.
