Molecules,
Год журнала:
2024,
Номер
29(21), С. 5090 - 5090
Опубликована: Окт. 28, 2024
Carbon–carbon
bond
formation
represents
a
key
reaction
in
organic
synthesis,
resulting
paramount
importance
for
constructing
the
carbon
backbone
of
molecules.
However,
traditional
metal-based
catalysis,
despite
its
advantages,
often
struggles
with
issues
related
to
efficiency,
selectivity,
and
sustainability.
On
other
hand,
while
biocatalysis
offers
superior
selectivity
due
an
extraordinary
recognition
process
substrate,
scope
applicable
reactions
remains
somewhat
limited.
In
this
context,
Artificial
Metalloenzymes
(ArMs)
Metallo
Peptides
(MPs)
offer
promising
not
fully
explored
solution,
merging
two
fields
transition
metal
catalysis
biotransformations,
by
inserting
catalytically
active
cofactor
into
customizable
protein
scaffold
or
coordinating
ion
directly
short
tunable
amino
acid
(Aa)
sequence,
respectively.
As
result,
these
hybrid
catalysts
have
gained
attention
as
valuable
tools
challenging
catalytic
transformations,
providing
systems
new-to-nature
properties
synthesis.
This
review
overview
recent
advances
development
ArMs
MPs,
focusing
on
their
application
asymmetric
carbon–carbon
bond-forming
reactions,
such
carbene
insertion,
Michael
additions,
Friedel–Crafts
cross-coupling
cyclopropanation,
underscoring
versatility
synthesizing
biologically
relevant
compounds.
Applied Organometallic Chemistry,
Год журнала:
2025,
Номер
39(2)
Опубликована: Янв. 26, 2025
ABSTRACT
The
present
work
demonstrates
the
synthesis
of
ester
and
ferrocene
groups
containing
new
terpyridine‐based
ligands
(
FRL
RL
)
their
selected
meal
complexes
FR‐Fe
,
FR‐Ru
RL‐Fe
RL‐Ru
.
Investigations
on
influence
binding
to
DNA/BSA
anticancer
activity
were
carried
out.
All
these
products
structurally
characterized
by
using
spectroscopic
analytical
techniques.
Notably,
molecular
structures
both
ester‐based
Fe(III)
complex
confirmed
single‐crystal
X‐ray
diffraction
analysis.
Additionally,
theoretical
calculations
employed
further
establish
synthesized
metal
complexes,
which
subsequently
utilized
for
docking
studies
evaluate
potential.
results
revealed
best
orientation
with
lowest
possible
energy
−10.20
kcal/mol
BSA
−8.30
DNA.
Furthermore,
interactions
all
compounds
investigated
UV–visible
absorption
(UV)
fluorescence
spectroscopy
(FL).
sites
constants
determined
Stern‐Volmer
equation.
Moreover,
cytotoxicity
assays
performed
against
lung
cancer
(A549),
liver
(Hep
G2),
normal
Vero
cell
lines,
benchmarked
cisplatin.
ligand
exhibited
significant
cytotoxic
action
an
IC
50
54.51
μM
compared
related
(i.e.,
69.86
μM)
A549
cells.
But
displayed
56.19
Hep
G2
cells,
demonstrating
better
potency
over
Abstract
The
one‐pot
synthesis
of
a
total
32
ruthenium(II)
and
osmium(II)
photosensitizers
bearing
substituted
2,2’‐bipyridines,
1,10‐phenanthrolines,
diaza
ligands
is
reported.
Whereas
most
these
were
already
reported
in
the
literature,
present
study
offers
extensive
datasets
ground‐
excited‐state
properties
highly
desirable
for
future
development
e.
g.,
machine
learning,
artificial
intelligence,
photoredox
catalysis.
All
absorbed
light
intensely
visible
part
spectrum,
with
Os(II)
absorbing
further
into
red
part.
Excited‐state
lifetimes
photoluminescence
quantum
yields
generally
larger
Ru(II)
than
analogs,
which
agrees
energy
gap
law.
redox
potentials
determined
all
investigated
covering
range
−0.21
to
−1.35
V
vs
.
SCE
oxidation
0.14
1.48
reduction.
A
procedure
counterion
exchange
generate
corresponding
PF
6
−
,
Cl
BF
4
NO
3
OTf
ClO
BAr
F−
six
photosensitizers.
synthetic
ease,
detailed
report
fundamental
photophysical
properties,
broad
open
opportunities
systematic
investigations
several
applications
streamline
developments
European Journal of Inorganic Chemistry,
Год журнала:
2024,
Номер
27(32)
Опубликована: Авг. 22, 2024
Abstract
A
crystalline
dihydroxy
substituted
Schiff
base
ligand
[
LH
]
was
involved
in
the
synthesis
of
three
copper(II)
complexes
viz
[Cu(LH)
2
(
Cu1
),
[Cu(LH)(bpy)]
Cu2
)
and
[Cu(LH)(phen)]
Cu3
(bpy=2,2’‐bipyridine
phen=1,10‐phenanthroline).
FTIR,
ESI‐MS,
elemental
analysis,
ESR
studies
NMR
techniques
were
employed
to
characterize
all
newly
synthesized
compounds.
Monoclinic
structure
with
space
group
P2
1
/n
LH)
confirmed
by
single
crystal
XRD
analysis.
The
molecular
optimized
using
density
functional
theory
(DFT)
at
B3LYP/LanL2DZ
levels
gas
phase.
According
DFT
investigations
exhibits
tetragonally
distorted
octahedral
geometry
around
Cu(II)
while
appeared
penta‐coordination
as
trigonal
bipyramidal
geometry.
UV‐Vis,
fluorescence
viscosity
titrations
used
examine
metal
complex
interactions
CT‐DNA
BSA
protein.
binding
results
suggest
that
bind
DNA
via
groove
mode.
Molecular
docking
performed
analyse
interaction
DNA.
Antioxidant
investigation
indicates
possesses
remarkable
ability
scavenge
radicals
against
DPPH
due
lowest
IC
50
value
211.20
μg/mL.
In‐vitro
cytotoxicity
assessed
MCF‐7
breast
cancer
cells
where
found
have
superiority
52.35
μm
over
other
analogues.
Acridine
orange/ethidium
bromide
staining
analysis
determine
apoptosis
cause
cell
death.
