Advanced Healthcare Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 26, 2024
Abstract
The
availability
of
second
near‐infrared
(NIR‐II)
excitable
two‐photon
photosensitizers
with
NIR‐I
emission
for
efficient
photodynamic
therapy
(PDT)
is
limited
by
challenges
in
molecular
design.
In
this
study,
a
NIR‐II
light‐excitable
conjugated
microporous
polymer
(
Tph‐Dbd
)
the
region
developed.
large
system
and
delocalized
electronic
structures
endow
absorption
cross‐section
under
light
excitation.
Moreover,
electron
acceptor
donor
units
within
π‐conjugated
backbones
result
high
signal‐to‐background
ratio
imaging,
as
well
separated
highest
occupied
orbital
lowest
unoccupied
distributions
excellent
singlet
oxygen
generation
ability.
activity,
emission,
good
biocompatibility,
photostability
allow
to
be
used
vitro
fluorescence
imaging
guided
PDT.
impressive
photothermal
effect
can
overcome
limitations
PDT
treatment
hypoxic
tumors.
This
study
highlights
strategy
designing
advanced
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 15, 2025
The
combination
of
photosensitizers
(PSs)
and
nanomaterials
is
a
widely
used
strategy
to
enhance
PS
efficacy
broaden
their
applicability.
However,
the
current
nanocarrier-based
delivery
strategies
focus
on
conventional
PSs,
neglecting
critical
issue
phototoxicity.
In
this
study,
DHUOCl-25,
an
activatable
(aPS)
activated
by
hypochlorous
acid,
synthesized
combining
silicon
source
structure
activation
unit.
DHUOCl-25
functions
as
silica
for
synthesizing
mesoporous
nanostrctures
(MSNs)
using
standardized
protocol,
enabling
synthesis
aPS-covalently
modified
MSNs
variety
biologic
therapeutic
applications.
On
one
hand,
resulting
nano-aPS
maintains
aPS
functionality
antibacterial
application
achieving
synergistic
action
via
MB
PDT
retained
cetyltrimethylammonium
bromide
(CTAB)
(antibacterial
agent)
(DHU-MSNs-2).
other
exhibits
MSN
properties
drug
loading,
facilitating
integration
photodynamic
therapy
with
chemotherapy
(DHU-MSNs-6)
tumors
demonstrating
against
spinal
metastases
lung
cancer.
These
results
validate
developing
novel
aPSs
expanding
MSNs.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(48)
Опубликована: Июль 18, 2024
Abstract
Two‐photon
excitation
(2PE)
represents
substantial
advantages
in
biophotonics
over
traditional
one‐photon
(1PE),
offering
enhanced
spatial
resolution
and
deeper
tissue
penetration
capabilities.
Since
its
introduction
the
1990s,
two‐photon
excited
microscopy
has
spurred
rapid
emergence
of
novel
2PE‐based
applications,
including
photodynamic
therapy
(PDT)
targeted
release
biologically
active
agents.
This
review
first
elucidates
fundamental
principles
2PE
before
comprehensively
examining
evolution
photosensitizers
(PSs)
for
PDT
(2P‐PDT),
covering
both
nanomaterials
small
molecules,
categorized
based
on
their
respective
characteristics.
Additionally,
it
explores
advancements
PS
development
integrating
2P‐PDT
with
other
therapeutic
modalities
(e.g.,
photothermal
therapy,
chemotherapy,
immunotherapy,
gene
etc.).
Subsequent
sections
provide
an
overview
photoactivatable
compounds
absorption
properties
controlled
various
agents
drugs,
genes,
gasotransmitters),
emphasizing
potential
anticancer
applications.
Last,
a
deep
discussion
deciphers
prospects
challenges
2P‐mediated
cancer
treatment,
particularly
concerning
clinical
translation.
Journal of Medicinal Chemistry,
Год журнала:
2024,
Номер
67(10), С. 8372 - 8382
Опубликована: Май 15, 2024
Using
photodynamic
therapy
(PDT)
to
trigger
nonconventional
cell
death
pathways
has
provided
a
new
scheme
for
highly
efficient
and
non-side
effects
drug-resistant
cancer
therapies.
Nonetheless,
the
unclear
targets
of
available
photosensitizers
leave
manner
PDT-induced
tumor
relatively
unpredictable.
Herein,
we
developed
novel
Ru(II)-based
photosensitizer,
Ru-Poma.
Possessing
E3
ubiquitin
ligase
CRBN-targeting
moiety
high
singlet
oxygen
yield
0.96,
Ru-Poma
was
demonstrated
specifically
photodegrade
endogenous
CRBN,
increase
lipid
peroxide,
downregulate
GPX4
GAPDH
expression,
consequently
induce
ferroptosis
in
cisplatin-resistant
cancerous
cells.
Furthermore,
with
deep
penetration
two-photon
excitation,
achieved
circumvention
3D
model.
Thus,
describe
first
sample
Ru(II)
complex
active
PDT.
Pharmaceuticals,
Год журнала:
2024,
Номер
17(6), С. 663 - 663
Опубликована: Май 21, 2024
Photodynamic
therapy
(PDT)
is
a
minimally
invasive
treatment
for
several
diseases.
It
combines
light
energy
with
photosensitizer
(PS)
to
destroy
the
targeted
cells
or
tissues.
A
PS
itself
non-toxic
substance,
but
it
becomes
toxic
target
through
activation
of
at
specific
wavelength.
There
are
some
limitations
PDT,
although
has
been
used
in
clinical
studies
long
time.
Two-photon
excitation
(TPE)
and
upconversion
(UC)
PDT
have
recently
developed.
TPE
nanoparticle-based
advantages
nanotechnology
that
emerged
as
an
attractive
therapeutic
agent
near-infrared
red
(NIR)
light-excited
whilst
UC
also
NIR
light-triggered
drug
release,
'caged'
imaging,
molecules
during
process
diagnosis,
cancers.
Angewandte Chemie International Edition,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 13, 2025
Abstract
Photoactivatable
metal
complexes
offer
the
prospect
of
novel
drugs
with
low
side
effects
and
new
mechanisms
action
to
combat
resistance
current
therapy.
We
highlight
recent
progress
in
design
platinum,
ruthenium,
iridium,
gold
other
transition
complexes,
especially
for
applications
as
anticancer
anti‐infective
agents.
In
particular,
understanding
excited
state
chemistry
related
identification
bioactive
species
(excited
metallomics/pharmacophores)
is
important.
metallodrugs
are
classified
here
photocatalysts,
photorelease
agents
ligand‐activated
Their
activation
wavelengths,
cellular
action,
experimental
theoretical
metallomics
states
photoproducts
discussed
explore
strategies
investigation
photoactivatable
metallodrugs.
These
have
potential
clinical
Photodynamic
Therapy
(PDT),
Photoactivated
Chemotherapy
(PACT)
Photothermal
(PTT).
Angewandte Chemie,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 13, 2025
Abstract
Photoactivatable
metal
complexes
offer
the
prospect
of
novel
drugs
with
low
side
effects
and
new
mechanisms
action
to
combat
resistance
current
therapy.
We
highlight
recent
progress
in
design
platinum,
ruthenium,
iridium,
gold
other
transition
complexes,
especially
for
applications
as
anticancer
anti‐infective
agents.
In
particular,
understanding
excited
state
chemistry
related
identification
bioactive
species
(excited
metallomics/pharmacophores)
is
important.
metallodrugs
are
classified
here
photocatalysts,
photorelease
agents
ligand‐activated
Their
activation
wavelengths,
cellular
action,
experimental
theoretical
metallomics
states
photoproducts
discussed
explore
strategies
investigation
photoactivatable
metallodrugs.
These
have
potential
clinical
Photodynamic
Therapy
(PDT),
Photoactivated
Chemotherapy
(PACT)
Photothermal
(PTT).
ACS Omega,
Год журнала:
2025,
Номер
10(7), С. 6544 - 6558
Опубликована: Фев. 11, 2025
This
paper
describes
the
DNA
interactions
of
near-infrared
(NIR)
benzylated
4-quinolinium
dicarbocyanine
dyes
containing
a
pentamethine
bridge
meso-substituted
either
with
bromine
(4)
or
hydrogen
(5)
atom.
In
pH
7.0
buffered
aqueous
solutions,
absorb
light
that
extends
into
range
up
to
∼950
nm.
The
unique
direct
strand
breakage
pUC19
is
sensitized
by
irradiating
an
850
nm
LED
laser
constitutes
first
published
example
photocleavage
upon
single-photon
chromophore
excitation
at
wavelength
greater
than
830
Brominated
dye
4,
which
more
stable
and
achieves
scission
in
higher
yield
its
hydrogen-bearing
counterpart
5,
cleaves
plasmid
under
905
illumination.
addition
increasing
amounts
solutions
converted
aggregated
form
4
monomer
bathochromic
absorption
overlaps
all
three
emission
wavelengths.
No
induced
circular
dichroism
fluorescence
signals
were
detected
when
was
present,
pointing
possible
external
binding
DNA.
Experiments
employing
radical-specific
fluorescent
probes
chemical
additives
showed
brominated
likely
breaks
strands
photosensitizing
hydroxyl
radical
production.
Micromolar
concentrations
relatively
nontoxic
cultured
Escherichia
coli
cells
dark
but
dramatically
reduced
survival
As
NIR
wavelengths
deeply
penetrate
biological
tissues,
we
envisage
future
use
carbocyanine
as
sensitizing
agent
phototherapeutic
applications.
