Chemical Design of Magnetic Nanomaterials for Imaging and Ferroptosis-Based Cancer Therapy

Chemical Reviews, Год журнала: 2025, Номер unknown

Опубликована: Фев. 14, 2025

Ferroptosis, an iron-dependent form of regulatory cell death, has garnered significant interest as a therapeutic target in cancer treatment due to its distinct characteristics, including lipid peroxide generation and redox imbalance. However, clinical application oncology is currently limited by issues such suboptimal efficacy potential off-target effects. The advent nanotechnology provided new way for overcoming these challenges through the development activatable magnetic nanoparticles (MNPs). These innovative MNPs are designed improve specificity ferroptosis induction. This Review delves into chemical biological principles guiding design ferroptosis-based therapies imaging-guided therapies. It discusses mechanisms attributes ferroptosis, composition MNPs, their mechanism action inducers, integration with advanced imaging techniques monitoring. Additionally, we examine convergence other strategies, chemodynamic therapy, photothermal photodynamic sonodynamic immunotherapy, within context nanomedicine strategies utilizing MNPs. highlights multifunctional surpass limitations conventional treatments, envisioning future drug-resistance-free, precision diagnostics treating recalcitrant cancers.

Язык: Английский

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Nanostructures and nanoparticles as medical diagnostic imaging contrast agents: A review

Materials Today Chemistry, Год журнала: 2024, Номер 40, С. 102233 - 102233

Опубликована: Авг. 5, 2024

Язык: Английский

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Biomolecule-based engineered nanoparticles for Cancer Theranostics

Coordination Chemistry Reviews, Год журнала: 2025, Номер 530, С. 216489 - 216489

Опубликована: Фев. 3, 2025

Язык: Английский

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Nanozyme-based cancer theranostics: A scientometric analysis and comprehensive review

Nano Today, Год журнала: 2024, Номер 57, С. 102386 - 102386

Опубликована: Июль 13, 2024

Язык: Английский

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Nanocatalytic medicine: An advanced catalysis-based imaging and therapy methodology

Coordination Chemistry Reviews, Год журнала: 2025, Номер 529, С. 216430 - 216430

Опубликована: Янв. 24, 2025

Язык: Английский

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Recent Advances in Bioresponsive Macrocyclic Gadolinium(III) Complexes for MR Imaging and Therapy

Dalton Transactions, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

This review summarizes recent advances in bioresponsive Gd( iii ) contrast agents, particularly those developed between 2019 and 2024. Three major types of probe that respond specifically to changes pH, chemicals, enzymes have been highlighted.

Язык: Английский

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Hetero‐Trimetallic Atom Catalysts Enable Targeted ROS Generation and Redox Signaling for Intensive Apoptosis and Ferroptosis

Advanced Materials, Год журнала: 2025, Номер unknown

Опубликована: Март 23, 2025

Abstract Reactive oxygen species (ROS) play crucial roles in cellular metabolic processes by acting as primary intracellular chemical substrates and secondary messengers for signal modulation. However, the artificial engineering of nanozymes to generate ROS is restricted their low catalytic efficiency, high toxicity, off‐target consumption. Herein, hetero‐trimetallic atom catalysts (TACs) anchored on a stable symmetrical pyramid structure are designed presence N P surface ligands from cross‐linked polyphosphazene interlayer‐coated MIL‐101(Fe). The 3D network TACs with uniform dispersion Cu, Co, Fe hetero‐single atoms effectively tailor active sites avoid metal sintering, thereby providing sufficient activity blooms. Nanovesicle membranes facilitate accumulation homologous targeting, recognition, endocytosis, addressing potentially toxicity defects. Therefore, outcome situ ROS‐bloom acts redox directly regulating oxidative stress tumor microenvironment. Meanwhile, intervene glutathione peroxidase 4, long‐chain acyl‐CoA synthetase cysteinyl aspartate specific proteinase‐3 pathways second messengers, fostering proclivity toward apoptosis lipid peroxidation‐regulated ferroptosis pathway concurrently, highlighting application prospects biomedical field.

Язык: Английский

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Mutually reinforced activatable NIR fluorescence/MR bimodal imaging enabled by tumor-specific biomarker amplification

Опубликована: Март 1, 2025

Язык: Английский

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Time-Resolved T1 and T2 Contrast for Enhanced Accuracy in MRI Tumor Detection

Biomaterials, Год журнала: 2025, Номер unknown, С. 123313 - 123313

Опубликована: Апрель 1, 2025

Язык: Английский

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PEDF-enriched extracellular vesicle for vessel normalization to potentiate immune checkpoint blockade therapy

Biomaterials Research, Год журнала: 2024, Номер 28

Опубликована: Янв. 1, 2024

The abnormal tumor vasculature acts as the physical and functional barrier to infiltration activity of effector T cells, leading low response rate immune checkpoint inhibitors (ICIs). Herein, antiangiogenic extracellular vesicles that enable normalization tumor-associated were prepared potentiate efficacy ICIs. Small exploited delivery platform protect protein, pigment epithelium-derived factor (PEDF), from proteolytic degradation. Along with physicochemical characteristics PEDF-enriched (P-EVs), their inhibitory effects on migration, proliferation, tube formation endothelial cells investigated in vitro. In tumor-bearing mice, it was confirmed that, compared bare PEDFs, P-EVs efficiently reduced vessel leakiness, improved blood perfusion, attenuated hypoxia. Consequently, when combined anti-PD-1 antibodies, remarkably augmented antitumor immunity, evidenced by increased CD8 + regulatory cells. These results suggest are promising therapeutics for tumors refractory

Язык: Английский

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