BODIPY-based nanoparticles for highly efficient photothermal/gas synergistic therapy against drug-resistant bacterial infection

Journal of Materials Science, Год журнала: 2024, Номер 59(41), С. 19628 - 19641

Опубликована: Окт. 24, 2024

Язык: Английский

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Ruthenium and platinum-based anticancer metallotherapeutics from the perspectives of photodynamic therapy and bioimaging applications

Chemical Papers, Год журнала: 2024, Номер unknown

Опубликована: Сен. 26, 2024

Язык: Английский

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One-Pot Synthesis of Tumor-Targeted Gold-Doped Cu_1.92S Plasmonic Nanodots for Enhanced NIR-Triggered, pH-Responsive PTT/PDT/CDT

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 17(1), С. 408 - 418

Опубликована: Дек. 25, 2024

Copper-based sulfides are attractive candidates for NIR I and II responsive photothermal therapy but often suffer from high hydrophobicity, suboptimal conversion, poor biostability biocompatibility. In the present work, a rapid, one-pot synthesis method was developed to obtain Au-doped Cu1.92S (ACSH NDs) dual plasmonic nanodots. ACSH NDs exhibit excellent peroxidase-like catalytic activity pH-responsive •OH radical generation along with efficient glutathione depletion under tumor microenvironment mimicking conditions. Upon exposure NIR-I laser light, demonstrate conversion efficiency of 47.44% as well significant photodynamic effect through singlet oxygen generation. The in situ hyaluronic acid capping endows nanodots highly selective uptake breast cancer cells both vitro vivo. Simultaneous chemodynamic NIR-triggered photothermal/photodynamic activities result synergistic cell death 98% inhibition single-dose mouse model study. Therefore, show remarkable potential single nanoplatform-actuated drug-free multimodal therapy.

Язык: Английский

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Are stimuli-responsive hybrid copolymer nanoparticles the next innovation in tumor drug delivery?

Expert Opinion on Drug Delivery, Год журнала: 2024, Номер unknown, С. 1 - 4

Опубликована: Дек. 27, 2024

Язык: Английский

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