检测新型精神活性物质的荧光传感器技术研究进展

Laser & Optoelectronics Progress, Год журнала: 2025, Номер 62(7), С. 0700002 - 0700002

Опубликована: Янв. 1, 2025

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Rational development of Nile Red derivatives with significantly improved specificity and photostability for advanced fluorescence imaging of lipid droplets

Biosensors and Bioelectronics, Год журнала: 2025, Номер 282, С. 117494 - 117494

Опубликована: Апрель 17, 2025

Язык: Английский

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Developing a polarity-specialized TICT fluorescent probe for wash-free and long-term monitoring lipid droplets dynamics

Talanta, Год журнала: 2025, Номер 294, С. 128191 - 128191

Опубликована: Апрель 19, 2025

Язык: Английский

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Facile Way to Differentiate Normal and Cancerous Tissues via Polarity-Sensitive Fluorescent Probes Based on 1,6-Naphthyridine Derivatives

Analytical Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 23, 2025

Cancer is a genetic disorder caused by the long-term interaction of many factors, which has become most important factor to take away human health; therefore, it essential develop more efficient and sensitive cancer detection technology. This study developed two polarity probes 1a 1b based on 1,6-naphthyridine moiety linked different targeting groups vinyl as π bridge. As solvent decreased, emission wavelength experienced blue shift, resulting in significant enhance fluorescence intensity 135-fold 53-fold, respectively, good linear relationship between Fmax Δf was established with high correlation coefficients. Furthermore, exhibited large Stokes shifts, photostability, low cytotoxicity, successfully intracellular lipid droplets mitochondria. Fluctuation detected real-time changes Moreover, probe capable monitoring mitochondrial during starvation or rapamycin-induced autophagy. It worth standing out could distinguish normal cells from cells, then also were applied for imaging differentiate tissues cancerous tissues, malignant tumor being 15.4-19.9 folds higher than that 5.3-7.2 times benign tissues. Therefore, this research offers potential applications diagnosis.

Язык: Английский

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Application of a wash-free NIR-fluorescent probe in detecting the polarity of lipid droplets and identifying NAFLD

Materials Today Chemistry, Год журнала: 2024, Номер 42, С. 102408 - 102408

Опубликована: Ноя. 17, 2024

Язык: Английский

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Lipid droplets targeting fluorescent probes with AIE properties for the diagnosis of fatty liver tissue

Journal of Industrial and Engineering Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 1, 2024

Язык: Английский

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A novel fluorescent probe with a large Stokes shift targeting lysosomes and lipid droplets and its application to cellular imaging

Journal of Industrial and Engineering Chemistry, Год журнала: 2024, Номер 145, С. 686 - 692

Опубликована: Ноя. 19, 2024

Язык: Английский

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An activatable “AIE + ESIPT” fluorescent probe for dual-imaging of lipid droplets and hydrogen peroxide in drug-induced liver injury model

Analytica Chimica Acta, Год журнала: 2024, Номер 1335, С. 343442 - 343442

Опубликована: Ноя. 20, 2024

Язык: Английский

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Near infrared lipid droplet specific fluorescent probes based on phenothiazine derivatives for wash-free imaging and diagnosis of non-alcoholic fatty liver

Journal of Industrial and Engineering Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Дек. 1, 2024

Язык: Английский

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