Abstract
The
zeolitic
imidazolate
frameworks
have
gained
significant
attention
in
various
applications
owing
to
their
exceptional
surface
area,
customizable
porosity,
and
excellent
thermal
chemical
stability,
making
them
a
remarkable
nanomaterial.
present
study
involved
the
utilization
of
ultrasonic‐assisted
techniques
integrate
tungstic
acid
into
framework
(TA@ZIF‐67)
with
aim
augmenting
photocatalytic
activity.
as‐synthesized
nanocomposite
was
characterized
using
X‐ray
diffraction
scanning
electron
microscopic
analysis
inspect
structural
aspects
morphology.
reduction
particle
size
TA@ZIF‐67
due
incorporation
results
higher
leading
improvement
activity
ZIF‐67.
assessment
performance
ZIF‐67
conducted
through
degradation
methylene
blue
(MB)
under
sunlight.
efficiency
observed
be
61%
85%,
respectively,
MB
solution
following
60
min
irradiation
period.
investigation
kinetics
based
on
rate
constant
values
revealed
that
presented
greater
removal
from
an
aqueous
solution.
pave
new
avenue
toward
design
MOF‐based
photocatalysts
for
water
treatments.
Journal of the American Chemical Society,
Год журнала:
2022,
Номер
144(51), С. 23438 - 23447
Опубликована: Дек. 13, 2022
Chronic
wound
is
a
common
complication
for
diabetic
patients,
which
entails
substantial
inconvenience,
persistent
pain,
and
significant
economic
burden
to
patients.
However,
current
clinical
treatments
chronic
wounds
remain
unsatisfactory.
A
prolonged
but
ineffective
inflammation
phase
in
the
primary
difference
between
normal
wounds.
Herein,
we
present
an
effective
antioxidative
system
(MOF/Gel)
healing
of
rats
through
integrating
metal
organic
framework
(MOF)
nanozyme
with
antioxidant
enzyme-like
activity
hydrogel
(Gel).
MOF/Gel
can
continuously
scavenge
reactive
oxygen
species
modulate
oxidative
stress
microenvironment
wounds,
leads
natural
transition
from
proliferation
phase.
Impressively,
efficacy
one-time-applied
was
comparable
that
human
epidermal
growth
factor
Gel,
widely
used
drug
various
treatments.
Such
effective,
safe,
convenient
meet
complex
demands.
Abstract
Porous
metal–organic
framework
(MOF)
liquids
with
permanent
porosity,
good
fluidity,
and
fine
dispersion
attract
broad
attention
in
catalysis,
transportation,
gas
storage,
chemical
separations.
Yet,
the
design
synthesis
of
porous
MOF
for
drug
delivery
remain
less
explored.
Herein,
a
simple
general
strategy
is
reported
to
prepare
ZIF‐91
liquid
(ZIF‐91‐PL)
via
surface
modification
ion
exchange.
The
cationic
nature
ZIF‐91‐PL
not
only
renders
it
antibacterial
but
also
high
curcumin
loading
capacity
sustained
release.
More
importantly,
acrylate
group
on
grafted
side
chain
makes
feasible
crosslink
modified
gelatin
through
light
curing,
obtained
hydrogel
shows
significantly
improved
healing
effect
wound
diabetes.
This
work
demonstrates
first
time,
MOF‐based
delivery,
further
fabrication
composite
may
have
potential
applications
biomedical
science.
The Journal of Antibiotics,
Год журнала:
2023,
Номер
76(10), С. 603 - 612
Опубликована: Июнь 19, 2023
Abstract
Currently,
antibiotic-resistant
bacteria
represent
a
serious
threat
to
public
health
worldwide.
Biofilm
formation
potentiates
both
virulence
and
antibiotic
resistance
of
bacteria.
Therefore,
the
discovery
new
antibacterial
antibiofilm
compounds
is
an
issue
paramount
importance
combat
prevent
hard-to-treat
bacterial
infections.
Zeolitic-imidazolate-frameworks
(ZIFs)
are
metallo-organic
known
have
various
interesting
chemical
biological
applications,
including
properties.
In
this
study,
we
synthesized
ZIF-67
nanoparticles,
formed
by
imidazolate
anions
cobalt
cations,
found
that
they
inhibit
growth
Acinetobacter
baumannii
,
Pseudomonas
aeruginosa
Staphylococcus
aureus
.
Sub-inhibitory
concentrations
were
also
able
significantly
reduce
biomass
pre-established
biofilms
these
pathogenic
On
other
hand,
nanoparticles
had
null
or
low
cytotoxicity
in
mammalian
cells
at
those
showing
activities.
Thus,
our
results
reveal
potential
be
used
against
Materials Today Bio,
Год журнала:
2024,
Номер
26, С. 101093 - 101093
Опубликована: Май 18, 2024
The
incidence
of
chronic
wound
healing
is
promoted
by
the
growing
trend
elderly
population,
obesity,
and
type
II
diabetes.
Although
numerous
dressings
have
been
studied
over
years,
it
still
challenging
for
many
to
perfectly
adapt
process
due
dynamic
complicated
microenvironment.
Aiming
at
an
optimal
reproduction
physiological
environment,
multifunctional
electrospinning
nanofibrous
membranes
(ENMs)
emerged
as
a
promising
platform
treatment
owing
their
resemblance
extracellular
matrix
(ECM),
adjustable
preparation
processes,
porousness,
good
conformability
site.
Moreover,
profiting
from
booming
development
human-machine
interaction
artificial
intelligence,
next
generation
intelligent
(iENMs)
based
dressing
substrates
that
could
realize
real-time
monitoring
proceeding
individual-based
therapy
has
evoked
surge
interest.
In
this
regard,
general
wound-related
biomarkers
are
overviewed
firstly
representative
iENMs
stimuli-responsive
materials
briefly
summarized.
Subsequently,
emergent
applications
highlighted.
Finally,
opportunities
challenges
next-generation
well
translating
into
clinical
practice
evaluated.
RSC Medicinal Chemistry,
Год журнала:
2024,
Номер
15(8), С. 2601 - 2621
Опубликована: Янв. 1, 2024
This
perspective
reviews
recent
advances
in
factors
affecting
diabetic
wound
healing
patients,
the
limitations
of
traditional
approaches
and
application
MOF
materials
healing.
