International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(7), С. 3822 - 3822
Опубликована: Март 29, 2024
Antidepressant
drugs
play
a
crucial
role
in
the
treatment
of
mental
health
disorders,
but
their
efficacy
and
safety
can
be
compromised
by
drug
degradation.
Recent
reports
point
to
several
found
concentrations
ranging
from
limit
detection
(LOD)
hundreds
ng/L
wastewater
plants
around
globe;
hence,
antidepressants
considered
emerging
pollutants
with
potential
consequences
for
human
wellbeing.
Understanding
implementing
effective
degradation
strategies
are
essential
not
only
ensure
stability
potency
these
medications
also
safe
disposal
line
current
environment
remediation
goals.
This
review
provides
an
overview
pathways
amitriptyline,
typical
tricyclic
antidepressant
drug,
exploring
chemical
routes
such
as
oxidation,
hydrolysis,
photodegradation.
Connex
issues
stability-enhancing
approaches
through
formulation
packaging
considerations,
regulatory
guidelines,
quality
control
measures
briefly
noted.
Specific
case
studies
amitriptyline
forecast
future
perspectives
challenges
this
field,
helping
researchers
pharmaceutical
manufacturers
provide
guidelines
most
employed
minimal
environmental
impact.
