A Tough Janus Hydrogel Patch with Strong Wet Adhesion and Self-Debonding for Oral Ulcer Treatment

Chemistry of Materials, Год журнала: 2024, Номер 36(10), С. 4976 - 4989

Опубликована: Май 9, 2024

Oral ulcers (OU) are the most common oral mucosal disease in humans across all geographic regions, seriously affecting patients' quality of life and even leading to irreversible loss function. Existing clinical treatments, such as ointments, sprays, patches, often washed out by saliva within a few hours, posing challenges for dentists. Adhesive hydrogel dressings show promise address these issues, but existing options lack wet adhesion, flexibility, gentle debonding, limiting their application dynamic environments like cavity. To overcome limitations, hydrogen-bond-based Janus patch was developed. N-[Tris(hydroxymethyl)methyl]-acrylamide (THMA) chitosan (CS) were selected composites adhesive layer this hydrogel, high-density hydrogen bonding provided THMA topological adhesion synergy CS greatly enhanced performance hydrogel. A high-tenacity poly(ethylene glycol) diacrylate (PEGDA)-based acts tough layer, providing effective physical barrier. The can instantly adhere wound withstand chewing, biting, other mouth movements; avoid external stimulation; continuously release drugs promote repair diseases. In particular, gently automatically debond after drug delivery, thereby achieving convenient operation excellent therapeutic efficacy.

Язык: Английский

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Multi-role conductive hydrogels for flexible transducers regulated by MOFs for monitoring human activities and electronic skin functions

Journal of Materials Chemistry B, Год журнала: 2024, Номер 12(25), С. 6190 - 6202

Опубликована: Янв. 1, 2024

Metal organic frameworks (MOFs) have garnered significant attention in the development of stretchable and wearable conductive hydrogels for flexible transducers. However, MOFs used hydrogel networks been hampered by low mechanical performance poor dispersibility aqueous solutions, which affect hydrogels, including toughness, limited self-recovery, short working ranges, conductivity, prolonged response-recovery times. To address these shortcomings, a novel approach was adopted micelle co-polymerization

Язык: Английский

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pH-responsive bioadhesive with robust and stable wet adhesion for gastric ulcer healing

Biomaterials, Год журнала: 2024, Номер 309, С. 122599 - 122599

Опубликована: Апрель 30, 2024

Язык: Английский

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Antibacterial Hydrogel Adhesives Based on Bifunctional Telechelic Dendritic-Linear–Dendritic Block Copolymers

Journal of the American Chemical Society, Год журнала: 2024, Номер 146(25), С. 17240 - 17249

Опубликована: Июнь 12, 2024

Antibiotic-resistant pathogens have been declared by the WHO as one of major public health threats facing humanity. For that reason, there is an urgent need for materials with inherent antibacterial activity able to replace use antibiotics, and in this context, hydrogels emerged a promising strategy. Herein, we introduce next generation cationic high versatility can be cured on demand less than 20 s using thiol-ene click chemistry (TEC) aqueous conditions. The approach capitalizes two-component system: (i) telechelic polyester-based dendritic-linear-dendritic (DLDs) block copolymers different generations heterofunctionalized allyl ammonium groups, well (ii) polyethylene glycol (PEG) cross-linkers functionalized thiol groups. These resulted highly tunable where performance adjusted modifying cross-linking density. Off-stoichiometric showed narrow directed toward Gram-negative bacteria. presence pending allyls opens up many possibilities functionalization biologically interesting molecules. As proof-of-concept, hydrophilic cysteamine hydrochloride N-hexyl-4-mercaptobutanamide, example hydrophobic alkyl chain, generated three-component networks. In case derivatives, broader was noted networks, inhibiting growth Gram-positive Additionally, these systems presented versatility, storage modulus values ranging from 270 7024 Pa stability profiles 1 56 days swelling experiments. Good biocompatibility skin cells strong adhesion multiple surfaces place alternatives conventional antibiotics.

Язык: Английский

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Gelatin-based adaptive injectable nanocomposite hydrogel for closure of irregular wounds and immunoregulation in diabetic wound healing

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 144313 - 144313

Опубликована: Май 1, 2025

Язык: Английский

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