Advanced Materials,
Год журнала:
2024,
Номер
36(15)
Опубликована: Янв. 17, 2024
Abstract
Nanotechnology
profoundly
affects
the
advancement
of
medicine.
Limitations
in
diagnosing
and
treating
cancer
chronic
diseases
promote
growth
nanomedicine.
However,
there
are
very
few
analytical
descriptive
studies
regarding
trajectory
nanomedicine,
key
research
powers,
present
landscape,
focal
investigative
points,
future
outlooks.
Herein,
articles
reviews
published
Science
Citation
Index
Expanded
Web
Core
Collection
from
first
January
2000
to
18th
July
2023
analyzed.
a
bibliometric
visualization
publication
trends,
countries/regions,
institutions,
journals,
categories,
themes,
references,
keywords
is
produced
elaborated.
Nanomedicine‐related
academic
output
increasing
since
COVID‐19
pandemic,
solidifying
uneven
global
distribution
performance.
While
China
leads
terms
quantity
has
numerous
highly
productive
USA
advantages
impact,
commercialization,
industrial
value.
Nanomedicine
integrates
with
other
disciplines,
establishing
interdisciplinary
platforms,
which
drug
delivery
nanoparticles
remain
points.
Current
focuses
on
integrating
nanomedicine
cell
ferroptosis
induction
immunotherapy.
The
keyword
“burst
testing”
identifies
promising
directions,
including
immunogenic
death,
chemodynamic
therapy,
tumor
microenvironment,
immunotherapy,
extracellular
vesicles.
prospects,
major
challenges,
barriers
addressing
these
directions
discussed.
Chemical Reviews,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 14, 2025
Ferroptosis,
an
iron-dependent
form
of
regulatory
cell
death,
has
garnered
significant
interest
as
a
therapeutic
target
in
cancer
treatment
due
to
its
distinct
characteristics,
including
lipid
peroxide
generation
and
redox
imbalance.
However,
clinical
application
oncology
is
currently
limited
by
issues
such
suboptimal
efficacy
potential
off-target
effects.
The
advent
nanotechnology
provided
new
way
for
overcoming
these
challenges
through
the
development
activatable
magnetic
nanoparticles
(MNPs).
These
innovative
MNPs
are
designed
improve
specificity
ferroptosis
induction.
This
Review
delves
into
chemical
biological
principles
guiding
design
ferroptosis-based
therapies
imaging-guided
therapies.
It
discusses
mechanisms
attributes
ferroptosis,
composition
MNPs,
their
mechanism
action
inducers,
integration
with
advanced
imaging
techniques
monitoring.
Additionally,
we
examine
convergence
other
strategies,
chemodynamic
therapy,
photothermal
photodynamic
sonodynamic
immunotherapy,
within
context
nanomedicine
strategies
utilizing
MNPs.
highlights
multifunctional
surpass
limitations
conventional
treatments,
envisioning
future
drug-resistance-free,
precision
diagnostics
treating
recalcitrant
cancers.
Asian Journal of Pharmaceutical Sciences,
Год журнала:
2023,
Номер
18(4), С. 100829 - 100829
Опубликована: Июль 1, 2023
Current
antitumor
monotherapy
has
many
limitations,
highlighting
the
need
for
novel
synergistic
anticancer
strategies.
Ferroptosis
is
an
iron-dependent
form
of
nonapoptotic
cell
death
that
plays
a
pivotal
regulatory
role
in
tumorigenesis
and
treatment.
Photodynamic
therapy
(PDT)
causes
irreversible
chemical
damage
to
target
lesions
widely
used
therapy.
However,
PDT's
effectiveness
usually
hindered
by
several
obstacles,
such
as
hypoxia,
excess
glutathione
(GSH),
tumor
resistance.
improves
efficacy
PDT
increasing
oxygen
reactive
species
(ROS)
or
reducing
GSH
levels,
also
enhances
ferroptosis
induction
due
ROS
effect
microenvironment
(TME).
Strategies
based
on
nanoparticles
(NPs)
can
subtly
exploit
potential
synergy
PDT.
This
review
explores
recent
advances
current
challenges
landscape
underlying
mechanisms
regulating
PDT,
well
nano
delivery
system-mediated
activity.
These
include
polymers,
biomimetic
materials,
metal
organic
frameworks
(MOFs),
inorganics,
carrier-free
NPs.
Finally,
we
highlight
future
perspectives
this
emerging
paradigm
targeted
cancer
therapies.
Nano TransMed,
Год журнала:
2023,
Номер
2(2-3), С. 100004 - 100004
Опубликована: Сен. 1, 2023
Extracellular
vesicles
(EVs),
which
are
natural
nanocarriers
characterized
by
a
phospholipid
bilayer
structure,
released
living
cells.
They
play
crucial
role
in
the
intercellular
transport
of
proteins,
nucleic
acids,
lipids,
and
metabolites,
facilitating
substance
delivery
information
exchange
between
In
light
recent
numerous
studies,
EVs
has
been
found
to
transcend
their
basic
as
mere
vehicle.
Instead,
they
demonstrate
an
impressive
array
biological
activities,
displaying
preventive
therapeutic
potential
mitigating
various
pathological
processes
encompassing
cancer,
neoplastic
proliferation,
infectious
diseases,
oxidative
trauma.
Particularly,
derived
from
edible
plants
(EPDEVs)
have
emphasized
for
extensive
range
physiological
regulatory
functions
animals
humans,
with
targeted
drug
through
oral
administration.
Leveraging
these
advantages,
EPDEVs
expected
excellent
competitiveness
clinical
applications
or
healthcare
products.
This
review
provides
brief
overview
biogenesis,
composition
EPDEVs,
summarizes
mechanisms.
It
also
analyzes
methods
isolating
purifying
plant-EVs,
assessing
advantages
disadvantages;
discusses
latest
advancements
biomedical
applications,
concludes
prospective
insight
into
research
development
directions
EPDEVs.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(20)
Опубликована: Март 26, 2024
The
emerging
cell
death
modality
of
ferroptosis
has
garnered
increasing
attention
for
antitumor
treatment
but
still
suffers
from
low
therapeutic
efficacy.
A
metal-organic
frameworks
(MOFs)-based
magnetic
nanozyme
(PZFH)
comprising
porphyrin-based
Zr-MOF
(PCN)
on
zinc
ferrite
(ZF)
nanoparticles
modified
with
hyaluronic
acid,
delivering
excellent
magnetophotonic
response
efficient
ferroptosis,
is
reported
here.
PZFH
shows
multienzyme-like
cascade
activity
encompassing
a
photon-triggered
oxidase-like
catalysis
to
generate
O
Biomaterials Research,
Год журнала:
2023,
Номер
27(1)
Опубликована: Фев. 9, 2023
Abstract
Background
Endometriosis
is
a
common
gynecological
disease
in
women
of
childbearing
age.
Commonly
used
treatment
methods,
such
as
endocrine
and
surgical
therapies,
display
poor
therapeutic
effects
with
high
relapse
probability.
Thus,
novel
treatments
for
endometriosis
are
required.
Methods
In
our
study,
polydopamine
(PDA),
letrozole
(LTZ),
agarose
(AG)
hydrogels
were
combined
to
construct
an
injectable
hydrogel
near-infrared
controlled
drug
delivery
named
LTZ-PDA@AG
treatment.
The
release
can
be
accurately
by
the
light
intensity,
exposure
duration,
concentration,
composition.
Meanwhile,
we
isolated
endometrial
stromal
cells
from
endometrium
patients
endometriosis,
constructed
rats’
model
verify
biological
hydrogel.
Results
Owing
sufficiently
deep
penetration
light,
displayed
temperature
increase
efficient
photothermal
therapy.
addition,
local
temperatures
further
enhance
diffusion
letrozole,
thereby
achieving
excellent
effect
vivo.
Importantly,
vivo
vitro
test
demonstrated
capacity
nanocomposite
endocrine-photothermal
synergistic
therapy
biocompatibility.
Conclusion
Our
work
proposes
concept
precision
photothermal-enhanced
which
proposed
first
time
demonstrates
potential
clinical
translation.
Trial
registration
Not
applicable.
Graphical
synthesized
under
NIR.
present
study
shows
Journal of Materials Chemistry B,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
A
novel
nanodrug
based
on
copper
sulfide
and
adenosine
aptamer
was
developed
to
potentially
suppress
TNBC
via
the
combination
of
PTT,
immune
activation
ferroptosis.
Due
to
the
inherent
low
immunogenicity
and
immunosuppressive
tumor
microenvironment
(TME)
of
malignant
cancers,
clinical
efficacy
application
immunotherapy
have
been
limited.
Herein,
a
bimetallic
drug-gene
co-loading
network
(Cu/ZIF-8@U-104@siNFS1-HA)
is
developed
that
increased
intracellular
labile
iron
pool
(LIP)
enhanced
weakly
acidic
TME
by
co-suppressing
dual
enzymatic
activities
carbonic
anhydrase
IX
(CA
IX)
cysteine
desulfurylase
(NFS1),
inducing
safe
efficient
initial
immunogenic
ferroptosis.
During
this
process,
Cu
Journal of Pharmaceutical Analysis,
Год журнала:
2024,
Номер
14(7), С. 100960 - 100960
Опубликована: Март 8, 2024
Ferroptosis
is
a
nonapoptotic
form
of
cell
death
and
differs
considerably
from
the
well-known
forms
in
terms
morphology,
genetics,
biochemistry.
The
three
primary
pathways
for
ferroptosis
are
system
Xc-/glutathione
peroxidase
4
(GPX4),
lipid
metabolism,
ferric
metabolism.
Since
discovery
ferroptosis,
mounting
evidence
has
revealed
its
critical
regulatory
role
several
diseases,
especially
as
novel
potential
target
cancer
therapy,
thereby
attracting
increasing
attention
fields
tumor
biology
anti-tumor
therapy.
Accordingly,
broad
prospects
exist
identifying
therapeutic
target.
In
this
review,
we
aimed
to
systematically
summarize
activation
defense
mechanisms
highlight
targets,
discuss
design
nanomedicines
regulation.
addition,
opted
present
advantages
disadvantages
current
research
provide
an
optimistic
vision
future
directions
related
fields.
Overall,
aim
new
ideas
further
inspire
strategies
disease
diagnosis
treatment.
