Materials Today Bio, Год журнала: 2024, Номер 29, С. 101346 - 101346
Опубликована: Ноя. 16, 2024
Язык: Английский
Dyes and Pigments, Год журнала: 2024, Номер 230, С. 112338 - 112338
Опубликована: Ноя. 1, 2024
Язык: Английский
Процитировано
3
International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 9071 - 9090
Опубликована: Сен. 1, 2024
Our study seeks to develop dual-modal organic-nanoagents for cancer therapy and real-time fluorescence imaging, followed by their pre-clinical evaluation on a murine model. Integrating NIR molecular imaging with nanotechnology, our aim is improve outcomes early-stage cutaneous melanoma offering more effective less invasive methods. This approach has the potential enhance both photothermal (PTT) Sentinel Lymph Node Biopsy (SLNB) procedures patients.
Язык: Английский
Процитировано
3
ACS Biomaterials Science & Engineering, Год журнала: 2024, Номер unknown
Опубликована: Сен. 12, 2024
Photochemotherapy has been recognized as a promising combinational modality for cancer treatment. However, difficulties such off-target drug delivery, systemic toxicity, and the hypoxic nature of tumor microenvironment remain hindrances to its application. To overcome these challenges, cell membrane camouflaged perfluorooctyl bromide (PFOB) dual-layer nanopolymersomes bearing indocyanine green (ICG) camptothecin (CPT), named MICFNS, were developed in this study, melanoma was exploited model MICFNS manufacture therapeutic Our data showed that able stabilize both ICG CPT nanocarriers can be quickly internalized by B16F10 cells due membrane-mediated homology. Upon NIR irradiation, trigger hyperthermia offer enhanced singlet oxygen production incorporation PFOB. With ≥10/2.5 μM ICG/CPT, + provide comparable
Язык: Английский
Процитировано
3
ACS Applied Materials & Interfaces, Год журнала: 2024, Номер unknown
Опубликована: Дек. 4, 2024
The integration of theranostics, which combines diagnostics with therapeutics, has markedly improved the early detection diseases, precise medication management, and assessment treatment outcomes. In realm oncology, organoplatinum-based supramolecular coordination complexes (SCCs) that can coload therapeutic agents imaging molecules have emerged as promising candidates for multimodal theranostics tumors. To address challenges tumor-targeted delivery SCCs, this study employs a cell membrane cloaking strategy to fabricate biomimetic metallacage nanoparticles (MCNPs) capabilities homologous targeting capabilities. Specifically, photosensitizer molecule (BTTP) containing AIE-active groups was assembled into C-BTTP through Pt-N coordination. This process endows strong NIR-II fluorescence in aggregated state significantly superior ROS generation compared precursor ligand. After being encapsulated F127, MCNPs were further cloaked U87 cancer membranes, creating achieve tumor-targeting Verified by vitro vivo experiments, enable initiate immunotherapy under photothermal photodynamic stimulation, leading synergistic antitumor effects. Furthermore, evaluation immunogenic death dendritic maturation rate tumor-bearing mice confirmed mechanism immunotherapy. provides an innovative enhancing efficiency offering versatile efficient minimally invasive development such represents significant advancement field nanomedicine, potentially transforming personalized targeted therapies.
Язык: Английский
Процитировано
3
Materials Today Bio, Год журнала: 2024, Номер 29, С. 101346 - 101346
Опубликована: Ноя. 16, 2024
Язык: Английский
Процитировано
2