Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(20)
Опубликована: Апрель 19, 2024
Abstract
Macrophages
play
an
essential
role
in
immunotherapy
and
tissue
regeneration
owing
to
their
remarkable
plasticity
diverse
functions.
Recent
bioengineering
developments
have
focused
on
using
external
physical
stimuli
such
as
electric
magnetic
fields,
temperature,
compressive
stress,
among
others,
micro/nanostructures
induce
macrophage
polarization,
thereby
increasing
therapeutic
potential.
However,
it
is
difficult
find
a
concise
review
of
the
interaction
between
stimuli,
advanced
micro/nanostructures,
polarization.
This
examines
present
research
stimuli‐induced
polarization
micro/nanoplatforms,
emphasizing
synergistic
fabricated
structure
stimulation
for
regeneration.
A
overview
advancements
investigating
impact
including
forces,
fluid
shear
photothermal
multiple
stimulations
macrophages
within
complex
engineered
structures,
provided.
The
prospective
implications
these
strategies
regenerative
medicine
immunotherapeutic
approaches
are
highlighted.
will
aid
creating
stimuli‐responsive
platforms
immunomodulation
Journal of Tissue Engineering,
Год журнала:
2024,
Номер
15
Опубликована: Янв. 1, 2024
The
rising
prevalence
of
diabetes
has
underscored
concerns
surrounding
diabetic
wounds
and
their
potential
to
induce
disability.
intricate
healing
mechanisms
are
multifaceted,
influenced
by
ambient
microenvironment,
including
prolonged
hyperglycemia,
severe
infection,
inflammation,
elevated
levels
reactive
oxygen
species
(ROS),
ischemia,
impaired
vascularization,
altered
wound
physicochemical
properties.
In
recent
years,
hydrogels
have
emerged
as
promising
candidates
for
treatment
owing
exceptional
biocompatibility
resemblance
the
extracellular
matrix
(ECM)
through
a
three-dimensional
(3D)
porous
network.
This
review
will
first
summarize
microenvironment
alterations
occurring
in
wounds,
aiming
provide
comprehensive
understanding
its
pathogenesis,
then
classification
recently
developed
be
presented,
encompassing
properties
such
hypoglycemic
effects,
anti-inflammatory
capabilities,
antibacterial
attributes,
ROS
scavenging
abilities,
promotion
angiogenesis,
pH
responsiveness,
more.
primary
objective
is
offer
valuable
reference
repairing
based
on
unique
microenvironment.
Moreover,
this
paper
outlines
avenues
future
advancements
hydrogel
dressings
facilitate
expedite
process
wounds.
Journal of Materials Chemistry B,
Год журнала:
2024,
Номер
12(4), С. 1007 - 1021
Опубликована: Янв. 1, 2024
Antibacterial
nanocomposite-integrated
microneedles
were
designed
for
infected
diabetic
wound
therapy.
The
nanocomposite
could
be
destroyed
by
high
glucose
and
exerted
a
powerful
synergistic
antibacterial
effect
against
bacterial
infections.
Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Апрель 4, 2024
Abstract
Chronic
wounds
are
inherently
vulnerable
to
external
mechanical
contact
owing
their
impaired
physiological
states.
Accidental
touching
may
lead
secondary
damage
delicate
wound
tissues,
including
deterioration
of
tissue
and
inflammation,
thereby
prolonging
the
healing
process.
In
addition,
patients
encounter
nociceptive
sensations,
indicative
physical
discomfort
potential
distress.
However,
traditional
dressings
for
chronic
fail
convey
adequate
perceptual
information
prevent
trauma.
An
electrostatic‐induction‐enabled
anti‐touching
hydrogel
dressing
(EAHD)
is
proposed,
which
promotes
reduces
touching‐induced
injuries.
The
EAHD
combines
a
proximity
sensor
pro‐healing
hydrogel.
can
detect
approaching
objects,
enabling
remote
perception.
More
importantly,
wireless
alarm
system
integrated
warn
against
detected
hazards
such
as
unintentional
touching.
Meanwhile,
significantly
accelerates
in
preclinical
diabetic
mice,
≈38%
faster
than
that
control
group.
This
study
proposes
novel
strategy
multifunctional
prevents
accidental
wound.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(20)
Опубликована: Апрель 19, 2024
Abstract
Macrophages
play
an
essential
role
in
immunotherapy
and
tissue
regeneration
owing
to
their
remarkable
plasticity
diverse
functions.
Recent
bioengineering
developments
have
focused
on
using
external
physical
stimuli
such
as
electric
magnetic
fields,
temperature,
compressive
stress,
among
others,
micro/nanostructures
induce
macrophage
polarization,
thereby
increasing
therapeutic
potential.
However,
it
is
difficult
find
a
concise
review
of
the
interaction
between
stimuli,
advanced
micro/nanostructures,
polarization.
This
examines
present
research
stimuli‐induced
polarization
micro/nanoplatforms,
emphasizing
synergistic
fabricated
structure
stimulation
for
regeneration.
A
overview
advancements
investigating
impact
including
forces,
fluid
shear
photothermal
multiple
stimulations
macrophages
within
complex
engineered
structures,
provided.
The
prospective
implications
these
strategies
regenerative
medicine
immunotherapeutic
approaches
are
highlighted.
will
aid
creating
stimuli‐responsive
platforms
immunomodulation
