Carbon Dots in the Pathological Microenvironment: ROS Producers or Scavengers?

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(29)

Опубликована: Июль 22, 2024

Reactive oxygen species (ROS), as metabolic byproducts, play pivotal role in physiological and pathological processes. Recently, studies on the regulation of ROS levels for disease treatments have attracted extensive attention, mainly involving ROS-induced toxicity therapy mediated by producers antioxidant scavengers. Nanotechnology advancements led to development numerous nanomaterials with ROS-modulating capabilities, among which carbon dots (CDs) standing out noteworthy nanomedicines own their distinctive physicochemical properties, high stability, excellent biocompatibility. Despite progress treating ROS-related diseases based CDs, critical issues such rational design principles remain underexplored. The primary cause these may stem from intricate amalgamation core structure, defects, surface states, inherent poses challenges establishing a consistent generalization. This review succinctly summarizes recently ROS-modulated approaches using CDs treatment. Specifically, it investigates established therapeutic strategies CDs-regulated ROS, emphasizing interplay between intrinsic structure generation or scavenging ability. conclusion raises several unresolved key scientific prominent technological bottlenecks, explores future perspectives comprehensive CDs-based therapy.

Язык: Английский

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Visible-light-excited room-temperature phosphorescent carbon dots: preparation strategies, mechanisms, and applications

Journal of Materials Chemistry C, Год журнала: 2024, Номер 12(24), С. 8668 - 8679

Опубликована: Янв. 1, 2024

This review article provides a comprehensive overview of the latest developments in visible-light-excited RTP CDs, which includes luminescence mechanisms, preparation strategies, property regulation, and potential applications.

Язык: Английский

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Advance of Near‐Infrared Emissive Carbon Dots in Diagnosis and Therapy: Synthesis, Luminescence, and Application

Advanced Healthcare Materials, Год журнала: 2024, Номер unknown

Опубликована: Авг. 1, 2024

Abstract Carbon dots (CDs) with good optical properties, biocompatibility, easy functionalization, and small size have attracted more attention laid a foundation for their applications in the biomedicine field. CDs emitted near‐infrared regions (NIR‐CDs) can achieve high penetration depth imaging produce cytotoxic substance disease treatment. Therefore, NIR‐CDs are promising materials to realize high‐quality imaging‐guided diagnostic therapeutic integration. This review first introduces current mainstream synthesis methods of by “top–down” “bottom–up”. Second, luminescence modes introduced, mechanisms based on carbon core state, surface molecular crosslinking enhanced emission summarized. Third, principles imaging, drug delivery, non‐invasive therapeutics introduced from view diagnosis therapy. Finally, prospects challenges biomedical biotechnological outlined.

Язык: Английский

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Orange carbon dots for Sn (IV) and ascorbic acid sensing in live cells and medicine

Microchemical Journal, Год журнала: 2024, Номер 202, С. 110784 - 110784

Опубликована: Май 17, 2024

Язык: Английский

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Advances in Carbon Dot Based Enhancement of Photodynamic Therapy of Tumors

ACS Applied Bio Materials, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 11, 2024

Photodynamic therapy has advantages of high selectivity, less invasiveness, and lethality for cancer cells compared with traditional treatment methods. However, some problems have hindered the development photodynamic therapy, such as limited penetration depth, lack oxygen, toxicity. Carbon dots are widely used in imaging tumors due to their excellent optical physicochemical properties, so effective methods been explored address issues via carbon dots. This review aims elucidate role cancer. Moreover, we summarize discuss strategies harness enhance therapy. Finally, many synergistic therapeutic modalities involving chemodynamic photothermal immunotherapy combination achieve more safer treatments.

Язык: Английский

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Advances in Red/Near infrared carbon dots in bioimaging, sensing, and phototherapeutic applications

Inorganic Chemistry Communications, Год журнала: 2024, Номер 163, С. 112389 - 112389

Опубликована: Апрель 5, 2024

Язык: Английский

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A superior near infrared fluorescent probe for revealing the relationship between peroxynitrite and Alzheimer's disease

Sensors and Actuators B Chemical, Год журнала: 2024, Номер 415, С. 135971 - 135971

Опубликована: Май 12, 2024

Язык: Английский

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An Aged Tree with a New Bloom: A Simple Spatiotemporal Programming Strategy Enables Carbon Dot Photosensitizers to Regulate Cell Pyroptosis for Enhanced Tumor Photodynamic-Immunotherapy

Nano Letters, Год журнала: 2024, Номер 24(46), С. 14709 - 14719

Опубликована: Ноя. 6, 2024

Pyroptosis induced by photodynamic therapy (PDT) is a promising field in both PDT and immunotherapy for tumors. However, effectively inducing tumor cell pyroptosis while triggering strong immune response using current photosensitizers remains challenging. Herein, the developed positively charged carbon dots (PCDs) nanoPSs were utilized to modulate first time through simple spatiotemporal programming strategy. Briefly, PCDs enabled precisely time-dependent targeting of membrane or lysosome. Upon light irradiation,

Язык: Английский

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Inulin-based fluorescent carbon dots as effective probes for rapid/visual detection of 3-nitrotyrosine

Microchemical Journal, Год журнала: 2025, Номер 209, С. 112750 - 112750

Опубликована: Янв. 11, 2025

Язык: Английский

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Near-infrared carbon dots: pioneering emerging frontiers in biomedical applications

New Carbon Materials, Год журнала: 2025, Номер 40(1), С. 131 - 153

Опубликована: Фев. 1, 2025

Язык: Английский

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