Frontiers in Chemistry,
Год журнала:
2024,
Номер
12
Опубликована: Июнь 24, 2024
Antimicrobial
photodynamic
therapy
(aPDT)
has
emerged
as
a
highly
promising
strategy
for
non-antibiotic
treatment
of
infections
due
to
its
unique
advantages
in
efficient
bactericidal
action
and
reduction
drug
resistance.
The
natural
photosensitizing
properties
curcumin
(Cur)
are
widely
acknowledged;
however,
limited
bioavailability
impeded
practical
application.
In
this
study,
we
developed
nanomaterial
called
Cur@ZIF-8@BA
by
encapsulating
Cur
within
ZIF-8
modifying
the
surface
with
boric
acid
(BA).
exhibits
pH-responsive
enhances
bacterial
binding,
thereby
effectively
promoting
therapy.
Moreover,
antibacterial
activity
against
E.
coli
,
Staphylococcus
aureus
A.
baumannii
is
significantly
increased
presence
light
compared
dark
environment.
mechanism
behind
may
be
that
BA
increases
affinity
towards
bacteria,
making
released
Zn
2+
from
increase
cell
membrane
permeability.
This
facilitates
delivery
into
cells,
resulting
generation
abundant
reactive
oxygen
species
(ROS)
subsequent
activity.
conclusion,
our
prepared
holds
great
promise
photodynamically
mediated
antimicrobial
strategy.
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Май 6, 2024
Abstract
Nanozyme,
characterized
by
outstanding
and
inherent
enzyme-mimicking
properties,
have
emerged
as
highly
promising
alternatives
to
natural
enzymes
owning
their
exceptional
attributes
such
regulation
of
oxidative
stress,
convenient
storage,
adjustable
catalytic
activities,
remarkable
stability,
effortless
scalability
for
large-scale
production.
Given
the
potent
regulatory
function
nanozymes
on
stress
coupled
with
fact
that
reactive
oxygen
species
(ROS)
play
a
vital
role
in
occurrence
exacerbation
metabolic
diseases,
nanozyme
offer
unique
perspective
therapy
through
multifunctional
achieving
essential
results
treatment
diseases
directly
scavenging
excess
ROS
or
regulating
pathologically
related
molecules.
The
rational
design
strategies,
nanozyme-enabled
therapeutic
mechanisms
at
cellular
level,
therapies
several
typical
underlying
are
discussed,
mainly
including
obesity,
diabetes,
cardiovascular
disease,
diabetic
wound
healing,
others.
Finally,
pharmacokinetics,
safety
analysis,
challenges,
outlooks
application
also
presented.
This
review
will
provide
some
instructive
perspectives
promote
development
strategies
disease
therapy.
Graphical
Journal of Medicinal Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 9, 2025
With
the
dilemma
of
limited
efficacy
individual
therapies,
it
is
crucial
to
develop
innovative
combination
therapy
systems
target
complex
pathogenesis
cancer.
In
this
study,
we
designed
a
nanoprodrug
ISL@MIL-101-ADT
facilitate
synergistic
delivery
hydrogen
sulfide
(H2S)
and
prodrug
ISL
for
specific
eradication
tumor
cells
with
minimal
toxicity
maximal
efficacy.
The
passively
targeted
tumors
through
enhanced
permeation
retention
effects,
followed
by
disintegration
release
IR780,
lonidamine
(LND),
H2S.
IR780
localizes
LND
mitochondria
enhance
therapeutic
effects
turn
on
phototherapy
chemotherapy
when
exposed
laser;
H2S
inhibits
procancer
signaling
pathways
mitochondrial
function.
vivo
experiments
have
demonstrated
that
exhibits
excellent
pharmacokinetic
properties
significant
inhibitory
effects.
Additionally,
possesses
outstanding
photothermal
fluorescence
imaging
capabilities.
Therefore,
strongly
believe
present
herein
holds
great
potential
application
in
cancer
therapy.
Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology,
Год журнала:
2024,
Номер
16(3)
Опубликована: Май 1, 2024
Abstract
The
misuse
of
antibiotics
has
led
to
increased
bacterial
resistance,
posing
a
global
public
health
crisis
and
seriously
endangering
lives.
Currently,
antibiotic
therapy
remains
the
most
common
approach
for
treating
infections,
but
its
effectiveness
against
multidrug‐resistant
bacteria
is
diminishing
due
slow
development
new
increase
drug
resistance.
Consequently,
developing
a\ntimicrobial
strategies
improving
efficacy
combat
infection
become
an
urgent
priority.
emergence
nanotechnology
revolutionized
traditional
treatment,
presenting
opportunities
refractory
infection.
Here
we
comprehensively
review
research
progress
in
nanotechnology‐based
antimicrobial
delivery
highlight
diverse
platforms
designed
target
different
resistance
mechanisms.
We
also
outline
use
combining
with
other
therapeutic
modalities
enhance
drug‐resistant
infections.
These
innovative
have
potential
susceptibility
overcome
Finally,
challenges
prospects
application
nanomaterial‐based
combating
are
discussed.
This
article
categorized
under:
Biology‐Inspired
Nanomaterials
>
Nucleic
Acid‐Based
Structures
Therapeutic
Approaches
Drug
Discovery
Nanomedicine
Infectious
Disease
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(22), С. 28041 - 28055
Опубликована: Май 20, 2024
Bacterial
infection
poses
a
significant
challenge
to
wound
healing
and
skin
regeneration,
leading
substantial
economic
burdens
on
patients
society.
Therefore,
it
is
crucial
promptly
explore
develop
effective
methodologies
for
bacterial
infections.
Herein,
we
propose
novel
approach
synthesizing
nanostructures
based
antisense
oligonucleotides
(ASOs)
through
the
coordination-driven
self-assembly
of
Zn2+
with
ASO
molecules.
This
aims
provide
synergistic
therapy
chronic
infections
caused
by
Staphylococcus
aureus
(S.
aureus).
The
resulting
hybrid
nanoparticles
successfully
preserve
structural
integrity
biological
functionalities
ASOs,
demonstrating
excellent
encapsulation
efficiency
bioaccessibility.
In
vitro
antibacterial
experiments
reveal
that
Zn-ASO
NPs
exhibit
antimicrobial
properties
against
Escherichia
coli,
aureus,
Bacillus
subtilis.
ability
attributed
high
concentration
metal
zinc
ions
generation
levels
reactive
oxygen
species.
Additionally,
ftsZ-ASO
effectively
inhibits
expression
ftsZ
gene,
further
enhancing
effect.
vivo
assays
demonstrate
promote
optimal
favorable
biocompatibility
S.
infections,
in
residual
infected
area
less
than
8%.
combined
strategy,
which
integrates
gene
metal-coordination-directed
self-assembly,
not
only
achieves
augmented
outcomes
but
also
expands
horizons
coordination
chemistry.
Moreover,
addresses
gap
application
metal-coordination
thereby
advancing
field
ASO-based
therapeutic
approaches.
Despite
the
advantages
of
high
tissue
penetration
depth,
selectivity,
and
non-invasiveness
photothermal
therapy
for
cancer
treatment,
developing
NIR-II
agents
with
desirable
performance
advanced
theranostics
ability
remains
a
key
challenge.
Herein,
universal
surface
modification
strategy
is
proposed
to
effectively
improve
vanadium
carbide
MXene
nanosheets
(L-V
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 10, 2024
The
World
Health
Organization
has
warned
that
without
effective
action,
deaths
from
drug-resistant
bacteria
can
exceed
10
million
annually,
making
it
the
leading
cause
of
death.
Conventional
antibiotics
are
becoming
less
due
to
rapid
bacterial
drug
resistance
and
slowed
new
antibiotic
development,
necessitating
strategies.
Recently,
materials
with
catalytic/enzymatic
properties,
known
as
nanozymes,
have
been
developed,
inspired
by
natural
enzymes
essential
for
eradication.
Unlike
recent
literature
reviews
broadly
cover
nanozyme
design
biomedical
applications,
this
review
focuses
on
latest
advancements
in
nanozymes
combating
resistance,
emphasizing
their
design,
structural
characteristics,
applications
combination
therapy,
future
prospects.
This
approach
aims
promote
development
especially
towards
clinical
translation.
