High-Z elements dominated bismuth-based heterojunction nano-semiconductor for radiotherapy-enhanced sonodynamic breast cancer therapy

Journal of Colloid and Interface Science, Год журнала: 2024, Номер 662, С. 914 - 927

Опубликована: Фев. 9, 2024

Язык: Английский

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In situ forming AIEgen-alginate hydrogel for remodeling tumor microenvironment to boost FLASH immunoradiotherapy

Biomaterials, Год журнала: 2025, Номер 320, С. 123281 - 123281

Опубликована: Март 20, 2025

Язык: Английский

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Orchestrating apoptosis and ferroptosis through enhanced sonodynamic therapy using amorphous UIO-66-CoOx

Journal of Colloid and Interface Science, Год журнала: 2024, Номер 667, С. 91 - 100

Опубликована: Апрель 10, 2024

Язык: Английский

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Amorphous CaCO3-bioreactor for tumor microenvironment regulation to reinforce tumor chemoimmunotherapy

Chemical Engineering Journal, Год журнала: 2024, Номер 490, С. 151838 - 151838

Опубликована: Май 3, 2024

Язык: Английский

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Calcium-based nanomaterials for cancer therapy

Journal of Materials Science, Год журнала: 2024, Номер 59(24), С. 10650 - 10676

Опубликована: Июнь 1, 2024

Язык: Английский

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Acidity-Responsive Fe-PDA@CaCO₃ Nanoparticles for Photothermal-Enhanced Calcium-Overload- and Reactive-Oxygen-Species-Mediated Tumor Therapy

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(33), С. 43364 - 43373

Опубликована: Авг. 6, 2024

Calcium-overload-mediated tumor therapy has received considerable interest in oncology. However, its efficacy been proven to be inadequate due insufficient calcium ion concentration at the site coupled with challenges facilitating efficient uptake by tumors, leading unsatisfactory therapeutic outcomes. In present study, carbonate nanoshell mineralized ferric polydopamine nanoparticles (Fe-PDA@CaCO

Язык: Английский

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Engineering of calcium overload for state-of-the-art tumor therapy

Chemical Engineering Journal, Год журнала: 2024, Номер 501, С. 157747 - 157747

Опубликована: Ноя. 17, 2024

Язык: Английский

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A Precision Mo₄VC₄‐Based Nanomedicine for Effective Cancer Elimination by Harnessing Senescence Induction and Immunogenic Response

Advanced Functional Materials, Год журнала: 2024, Номер unknown

Опубликована: Дек. 27, 2024

Abstract Interest in therapies that influence cell senescence to regulate cancer is increasing. However, the understanding of prolonged state senescent cells and interactions involved when utilizing promote alongside other techniques suppress progression limited. This study introduces an innovative artificial nanozyme named MVPR, constructed from vanadium MXene (Mo 4 VC ) combined with cyclin‐dependent kinase inhibitors Palbociclib Arg‐Gly‐Asp, for precise targeting membranes. Within tumor environment, MVPR initiates a cascade catalytic reactions, boosting glutathione consumption, generating reactive oxygen species (ROS). When damage ROS exceeds cellular repair capabilities, redox balance disrupted, resulting apoptosis. Alternatively, can be triggered under different circumstances. Senescent impede their own nearby growth by releasing cytokines, thereby effectively curtail uncontrolled proliferation. Furthermore, immune response recruitment evoked metal ions together enhance immunotherapeutic effect, system activity augmenting CD4 + /CD8 T Cancer are eliminated through actions pro‐senescence, enzyme catalysis, immunogenic response. proposes pro‐senescence strategy anti‐tumor therapy.

Язык: Английский

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Multifunctional nanoparticles for enhanced sonodynamic–chemodynamic immunotherapy with glutathione depletion

Nanomedicine, Год журнала: 2024, Номер 19(2), С. 145 - 161

Опубликована: Янв. 1, 2024

Aim: This study aimed to develop a sonodynamic–chemodynamic nanoparticle functioning on glutathione depletion in tumor immunotherapy. Materials & methods: The liposome-encapsulated 2,2-azobis[2-(2-imidazolin-2-yl) propane] dihydrochloride (AIPH) and copper–cysteine nanoparticles, AIPH/Cu-Cys@Lipo, were synthesized with one-pot method. 4T1 cells injected into female BALB/c mice for modeling. Results: AIPH/Cu-Cys@Lipo was well synthesized. It generated alkyl radicals upon ultrasound stimulation. promoted the generation of -OH via Fenton-like reaction. Both vitro vivo experiments verified that significantly inhibited development by decreasing mitochondrial membrane potential, activating CD4+ CD8+ T promoting expression IL-2 TNF-α. Conclusion: provides high-quality strategies safe effective

Язык: Английский

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Bi-specific nanoparticle-based engager capable of in situ activation of anti-tumor immune responses for postoperative cancer immunotherapy

Chemical Engineering Journal, Год журнала: 2024, Номер 485, С. 150068 - 150068

Опубликована: Фев. 28, 2024

Язык: Английский

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