Опубликована: Янв. 1, 2024
Язык: Английский
Materials Today Bio, Год журнала: 2024, Номер 26, С. 101113 - 101113
Опубликована: Июнь 1, 2024
Burns represent a prevalent global health concern and are particularly susceptible to bacterial infections. Severe infections may lead serious complications, posing life-threatening risk. Near-infrared (NIR)-assisted photothermal antibacterial combined with antioxidant hydrogel has shown significant potential in the healing of infected wounds. However, existing agents typically metal-based, complicated synthesize, or pose biosafety hazards. In this study, we utilized plant-derived blackcurrant extract (B) as natural source for both properties. By incorporating B into G-O crosslinked through Schiff base reaction between gelatin (G) oxidized pullulan (O), resulting G-
Язык: Английский
Процитировано
8
International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 140325 - 140325
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
1
ACS Applied Polymer Materials, Год журнала: 2025, Номер unknown
Опубликована: Янв. 9, 2025
With the rapid advancement of artificial intelligence, flexible wearable sensors based on conductive hydrogels have gained significant attention. However, conventional often use toxic cross-linkers to achieve desirable tensile strength by forming a three-dimensional network structure. This impedes their potential applications in sensors. In this study, we present an approach construct purely physically cross-linked liquid metal-reduced graphene oxide (GO) composite hydrogel, entirely free from cross-linkers. The results show that hydrogel has outstanding stretchable properties (strain: 348.22%, stress: 4.239 MPa). By optimally designing hydrogel's structure, favorable sensitivity coefficients: optimum gauge factor = 20.2 (0–100% strain, R2 0.98), and wide photothermal response range (808–850 nm) were obtained. Further, incorporation reduced GO @ metal particles (rGO@LM) enhances ability strain sensing performance. work provides pathway for development with high multifunctional responsiveness, offering promising motion detection temperature monitoring
Язык: Английский
Процитировано
0
Acta Biomaterialia, Год журнала: 2025, Номер unknown
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Chemistry - An Asian Journal, Год журнала: 2024, Номер 19(15)
Опубликована: Май 24, 2024
Abstract Combining exogenous and endogenous antibacterial mechanisms has been demonstrated to enhance therapeutic efficacy significantly. This study constructs an innovative type of nanocomposite hydrogels with injectable dual‐crosslinked networks dual‐stimuli responsiveness. The primary network establishes imine bonds between the functionalized dextran featuring norbornenes aldehydes (NorAld‐Dex) quaternized chitosan (QCS). provide self‐healing, injectability, pH‐responsiveness hydrogel network. secondary is established by integrating thiolated mesoporous silica‐coated titanium dioxide nanoparticles (TiO 2 @MS‐SH) into via ultrasound‐activated thiol‐norbornene reaction NorAld‐Dex. microstructures properties NorAld‐Dex/QCS/TiO @MS‐SH can be fine‐tuned adjusting sonication time increase amount crosslinks in Effective performance at low pH synergistic effect acid‐induced dissociation network, protonated QCS, reactive oxygen species (ROS) generated TiO under ultrasound irradiation. In summary, advanced dual stimuli‐responsive platform customizable properties, offering great potential for biomedical applications.
Язык: Английский
Процитировано
3
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 278, С. 135038 - 135038
Опубликована: Сен. 10, 2024
Язык: Английский
Процитировано
3
Advanced Functional Materials, Год журнала: 2024, Номер unknown
Опубликована: Окт. 10, 2024
Abstract Photothermal hydrogels (PTHs) are considered next‐generation biomaterials as they offer remotely defined biophysical information of the extracellular milieu. PTHs allow precise and non‐genetic control for regeneration native tissues, which is ultimate goal tissue engineering (TE). Molecular physical properties PTHs, such components, structural configurations, mechanical characteristics, collectively serve determinants understanding dynamic response clinical translation. have entered a period fruition due to development numerous manufacturing technologies polymeric matrices. Herein, this review comprehensively meticulously elucidates mechanisms regenerative therapeutics underlying design fabrication PTHs. Recent advances in photothermal principles various categories agents (PTAs) been extensively discussed. Vital components structures summarized enable efficacious therapeutic energy delivery. Emerging applications TE also demonstrated, expand strategies intrinsic injured tissues. Then deliberate chemical enhance prognosis while highlighting challenges associated with In review, we aim provide guidance prospects exploration innovation field TE.
Язык: Английский
Процитировано
2
Опубликована: Янв. 1, 2024
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Язык: Английский
Процитировано
1
ACS Applied Nano Materials, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 15, 2024
Biofilm and multidrug-resistant bacteria limit therapy effects on keratitis. Hence, we developed an all-in-one strategy based a photothermal trigger to combat eradicate biofilm. In the nanoplatforms, BSA-Ag2Te nanoparticles (NPs) fabricated by one-step synthesis approach were utilized as agents generate low temperature (40–48 °C) then modified with RGD (Arg-Gly-Asp) increase drug concentration retention in cornea. The heat generated from can accelerate Ag+ release. addition, laser-triggered release of significantly ROS content bacteria. This synergistic could effectively biofilm (PPT) combination ROS. Based treatment PTT, Ag+, ROS, BSA-Ag2Te@RGD NPs exhibited outstanding antibacterial mice MRSA-infected keratitis model. will be promising candidates for applications low-temperature PTT bacterial treatments.
Язык: Английский
Процитировано
1
Advanced Healthcare Materials, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 27, 2024
Abstract Adhesive hydrogels characterized by structural properties similar to the extracellular matrix, excellent biocompatibility, controlled degradation, and tunable mechanical have demonstrated significant potential in biomedical applications, including tissue engineering, biosensors, drug delivery systems. These exhibit remarkable adhesion target substrates can be rationally engineered meet specific requirements. In recent decades, adhesive experienced advancements driven introduction of numerous multifunctional design strategies. This review initially summarizes chemical bond‐based strategies for adhesion, encompassing static covalent bonds, dynamic non‐covalent interactions. Subsequently, multiple functionalities imparted these diverse strategies, highly stretchable tough performances, responsiveness microenvironments, anti‐freezing/heating properties, conductivity, antibacterial activity, hemostatic are discussed. addition, advances applications hydrogels, focusing on repair, delivery, medical devices, wearable sensors reviewed. Finally, current challenges highlighted future trends this rapidly evolving field
Язык: Английский
Процитировано
1