Advanced Healthcare Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 4, 2024
Abstract
Regulation
of
bone
microenvironment
(BME)
including
innate
pH
values
and
metal
ions
affects
cellular
functions
activities
osteoblasts
osteoclasts,
thereby
significantly
influencing
the
process
regeneration.
How
to
achieve
multiple
effective
regulations
BME
through
cascade
effects
via
facile
material
design
fabrication
facilitate
osteogenesis
remains
a
challenge.
Herein,
facilely‐designed
resorbable
guided
regeneration
membrane
(PCL/DEX@Ca‐Zol)
based
on
drug‐loaded
metal‐organic
framework
is
reported.
Thereinto,
calcium
ions,
zoledronic
acid,
dexamethasone
embedded
in
can
be
responsively
released
specifically
inside
defect
an
acid‐triggered
manner
synergistically
regulate
by
neutralization
value,
enhancement
osteogenic
differentiation
mineralization,
inhibition
osteoclasts
one‐go.
Along
with
polycaprolactone
as
structural
support
for
fully
utilized
components
composite
material,
enhances
minimized
side
accordingly
achieved
assistance
modulation
effects.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 10, 2024
Over
the
past
two
decades,
iron-based
metal-organic
frameworks
(Fe-MOFs)
have
attracted
significant
research
interest
in
biomedicine
due
to
their
low
toxicity,
tunable
degradability,
substantial
drug
loading
capacity,
versatile
structures,
and
multimodal
functionalities.
Despite
great
potential,
transition
of
Fe-MOFs-based
composites
from
laboratory
clinical
products
remains
challenging.
This
review
evaluates
key
properties
that
distinguish
Fe-MOFs
other
MOFs
highlights
recent
advances
synthesis
routes,
surface
engineering,
shaping
technologies.
In
particular,
it
focuses
on
applications
biosensing,
antimicrobial,
anticancer
therapies.
addition,
emphasizes
need
develop
scalable,
environmentally
friendly,
cost-effective
production
methods
for
additional
meet
specific
requirements
various
biomedical
applications.
ability
combine
therapies,
hurdles
still
remain,
including
a
deeper
understanding
therapeutic
mechanisms
potential
risks
resistance
overdose.
Systematically
addressing
these
challenges
could
significantly
enhance
prospects
potentially
facilitate
integration
into
mainstream
practice.
Journal of Pharmaceutical and Biomedical Analysis Open,
Год журнала:
2024,
Номер
4, С. 100037 - 100037
Опубликована: Авг. 8, 2024
The
biomedicine
scientific
field
has
made
continuous
progress,
introducing
various
pharmaceutical
compounds
to
enhance
human
life.
While
these
advancements
bring
benefits,
the
unregulated
use
of
raises
concerns,
particularly
regarding
their
presence
in
environment
and
potential
adverse
effects
on
health.
Therefore,
assessment
by
analytical
strategies
is
imperative
for
comprehending
appraising
interactions
across
diverse
matrices.
In
this
sense,
solid-based
microextraction
procedures
have
shed
light
challenging
task
evaluating
complex
samples.
Moreover,
miniaturized
are
firmly
rooted
principles
green
chemistry,
thereby
presenting
more
environmentally
friendly
approaches
than
traditional
extraction
methods.
Consequently,
significant
endeavors
been
undertaken
introduce
novel
sorbent
materials
that
foster
a
selective
interaction
with
target
analytes.
Having
mind,
molecularly
imprinted
polymers
(MIPs)
emerge
as
solution,
providing
binding
sites
capable
interacting
analyte
within
sample.
integration
MIPs
phases
led
strides
advancing
evaluation
different
Hence,
review
offer
comprehensive
overview
current
applications
combined
