Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер unknown, С. 106516 - 106516
Опубликована: Дек. 1, 2024
Язык: Английский
Small Science, Год журнала: 2024, Номер unknown
Опубликована: Июль 21, 2024
Microneedles (MNs) have emerged as a promising transdermal antimicrobial delivery system, providing precise and localized drug while complemented with noninvasiveness patient compliance. Currently, the topical application of antimicrobials restricts drugs to critical areas wound bed, largely due barriers posed by necrotic tissue, scab formation, bacterial biofilms, which severely diminish bioavailability therapeutics. MNs enabled efficient targeted overcome many chronic challenges. Over past decade, significant progress has been made develop unique properties tailored for vaccines, anticancer, antimicrobials. As ongoing research continues refine MN design, material properties, formulations, potential revolutionizing efficacy, experience, therapeutic outcomes remains at forefront scientific research. In this review, insights are provided into latest progress, current developments, diverse applications delivery. Herein, translational is highlighted perspective on challenges associated clinical translation provided. Furthermore, review aids in identifying gaps empowering contributing future implementation cutting‐edge systems effectively tackle resistance.
Язык: Английский
Процитировано
5
Nano Research, Год журнала: 2024, Номер 17(8), С. 7436 - 7448
Опубликована: Май 18, 2024
Язык: Английский
Процитировано
4
Advanced Functional Materials, Год журнала: 2025, Номер unknown
Опубликована: Фев. 10, 2025
Abstract The skin microenvironment is a highly intricate and dynamic system, characterized by an acidic pH, diverse microbiota, various metabolites, numerous enzymes, creating both challenges opportunities for the development of innovative drug delivery systems. Dissolving Microneedles (MNs) have emerged as promising, pain‐free alternative to conventional invasive injections, offering ability deliver therapeutics through gradual degradation within skin's interstitial fluids. Building upon unique properties dissolving MNs, novel concept introduced wherein MNs serve in situ chemical reaction chambers. In this framework, can reactants or catalysts skin, enabling initiation specific reactions, such prodrug activation targeted therapy, harmful enhanced synthesis beneficial molecules. Moreover, review systematically explores potential chambers, discussing key aspects their sustained release mechanisms, design strategies, range therapeutic applications. Finally, forward‐looking perspective provided on future addressing broader clinical translation application personalized medicine.
Язык: Английский
Процитировано
0
Computer Methods in Biomechanics & Biomedical Engineering, Год журнала: 2025, Номер unknown, С. 1 - 19
Опубликована: Март 20, 2025
Drug delivered from the microneedle (MN) tip diffuses across viscoelastic skin before entering blood compartment and being absorbed. Reversible uptake kinetics between tissue compartments, reversible specific saturable binding with its receptors, endocytosis are given due attention. Simulations predict that, unlike thinning, viscoelasticity a higher Young's modulus value, as in an older person, inhibit verapamil diffusion within skin, metabolism stabilises concentrations compartments. Simultaneously, irreversible improve drug compartment, facilitating receptor-mediated endocytosis. The results also that internalised increases time at slower internalisation rates; however, rates, it attains peak value gradually diminishing. Furthermore, rate of lysosomal degradation escalates, concentration diminishes shifts upward. A comprehensive sensitivity analysis has been performed because uncertainty about several crucial parameters. Our findings align well existing literature.
Язык: Английский
Процитировано
0
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 284, С. 138201 - 138201
Опубликована: Ноя. 29, 2024
Язык: Английский
Процитировано
3
Advanced Therapeutics, Год журнала: 2024, Номер 7(12)
Опубликована: Ноя. 12, 2024
Abstract Skin aging is characterized by a deterioration of skin quality over time resulting from physiological changes and oxidative stress (OS). Superoxide dismutase (SOD) an effective antioxidant enzyme widely used as food supplement cosmetic additive to alleviate OS retard aging. However, conventional SOD delivery routes commonly yield unsatisfactory results due limited stability, compromised bioavailability, low absorption efficiency in the gastrointestinal (GI) tract. These issues are addressed developing SOD‐encapsulated polymeric microneedle (PMN) patches for efficient transdermal delivery. The use highly stable isolated hot spring microbe ensures its reactivity throughout PMN fabrication application. This vehicle demonstrated excellent effectiveness through inhibiting skin‐aging promoting hair growth validated extensive vivo experiments using D‐galactose (D‐gal) induced aging‐mouse model. SOD‐PMNs promoted regeneration follicles, increased melanin synthesis, decreased lipid oxidation, elevated antioxidative capacity tissue. success promises wide applicability pharmaceutical industries.
Язык: Английский
Процитировано
0
Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер unknown, С. 106516 - 106516
Опубликована: Дек. 1, 2024
Язык: Английский
Процитировано
0