Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Апрель 12, 2024
Abstract
The
treatment
of
diabetic
wounds
remains
a
major
clinical
challenge
owing
to
bacterial
infection,
defects
in
angiogenesis,
and
the
corresponding
inhibition
cell
activity
extracellular
matrix
deposition.
In
this
study,
core-shell-type
nanosystem
was
developed
using
graphdiyne
(GDY)
nanoparticles
covered
with
gelatin
investigate
its
effects
on
wound
healing.
were
loaded
transforming
growth
factor
β
(TGF-β)
via
electrostatic
self-assembly
promote
angiogenesis
migration.
photothermal
GDY
applied
achieve
controllable
drug
release
antibacterial
properties.
This
could
rapidly
TGF-β
after
irradiation
by
near-infrared
rays
(NIR)
without
damaging
biological
activities.
associated
observed
30
seconds
nanoparticles,
temperature
set
at
safe
range
(<49.6
°C).
Besides,
gels
possessed
good
biocompatibility
promoted
migration
vitro.
After
implantation,
hydrogels
group
showed
higher
healing
rate
than
control
mouse
models
14
days
exhibited
evident
tissue
regeneration,
including
study
presents
method
for
fabricating
dressings
an
effective
NIR-response
strategy
designing
drug-delivery
nanosystems
cellular
factors.
Molecules,
Год журнала:
2025,
Номер
30(3), С. 737 - 737
Опубликована: Фев. 6, 2025
Absorption
of
exudates
is
crucial
for
moist
wound
treatment,
particularly
in
chronic
care
applications.
However,
controlling
with
current
gel-based
dressings
has
challenges,
such
as
the
risk
bacterial
infection
during
long-term
transportation
and
use.
In
this
study,
a
cellulose
(BC)/polyvinyl
alcohol
(PVA)
composite
hydrogel
(PBC)
was
prepared
by
simple
method
using
citric
acid
(CA)
crosslinking
agent.
Fourier-transform
infrared
spectroscopy
showed
that
reaction
between
carboxyl
group
CA
hydroxyl
BC-PVA
enhanced
its
hydrophilicity.
Sol–gel
analysis
confirmed
an
increase
PVA
content
led
to
stronger
polymer
network
hydrogel.
Wide-angle
X-ray
diffraction
results
at
low
concentrations,
tendency
connect
chains
crystallinity
increased.
addition,
dressing
demonstrated
excellent
water
absorption
capacity;
swelling
rate
reached
3485.3%
within
one
hour,
no
cytotoxic
effect
observed
on
L929
fibroblast
line
vitro.
The
designed
exhibited
ability
resist
bacteria.
Therefore,
new
PBC
biomaterial
certain
potential
various
applications,
highly
absorbent
dressing.
ACS Biomaterials Science & Engineering,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 20, 2025
Excessive
oxidative
stress,
chronic
inflammation,
and
impaired
vascularization
are
the
main
barriers
to
diabetic
wound
repair.
A
decellularized
extracellular
matrix
(dECM)
with
a
native
ECM
structure
is
promising
biomaterial
candidate
for
healing.
However,
traditional
decellularization
process
(reagents)
can
diminish
structural
stability,
mechanical
properties,
bioactive
components
of
dECM.
To
address
these
issues,
we
developed
an
intrinsically
kelp
scaffold
(Im-Gly2)
using
natural
gentle
deep
eutectic
solvents
(DES)
accelerating
Im-Gly2
had
stable
porous
3D
(80.7
μm)
suitable
which
could
support
cell
growth,
proliferation,
migration.
Due
retention
fucoidan,
polyphenols
(735.3
μg/g),
flavonoids,
demonstrated
intrinsic
antioxidant
immunomodulatory
effects.
It
effectively
reduced
reactive
oxygen
species
(ROS)
production
in
RAW264.7
macrophages
promoted
their
differentiation
into
M2
phenotype.
Notably,
tube
formation
through
paracrine
mechanisms
by
inducing
expression
transforming
proliferative
cytokines
from
macrophage.
In
vivo,
accelerated
healing
wounds
alleviating
angiogenesis,
granulation
tissue
formation,
collagen
deposition,
re-epithelialization.
Taken
together,
our
study
provides
novel
strategy
fabricating
dECM
without
cross-linking
exogenous
substances
Journal of Microencapsulation,
Год журнала:
2025,
Номер
unknown, С. 1 - 24
Опубликована: Март 23, 2025
Hydrogels
are
three-dimensional
structures
that
replicate
natural
tissues'
extracellular
matrix
(ECM).
They
essential
for
transporting
exudates,
gases,
and
moisture
facilitating
cellular
interactions
in
tissue
engineering
wound
healing.
The
choice
of
primary
material
designing
the
scaffold
is
necessary
to
be
paid
more
attention
rather
than
common
sources,
including
plant
fibres
like
cotton,
bamboo,
algae,
as
well
bacterial
marine-derived
materials.
Among
them,
cellulose-based
polymers
especially
valued
their
biocompatibility
ability
promote
Chronic
diabetic
wounds
pose
unique
treatment
challenges,
such
necrosis
infection
risks.
Consequently,
a
growing
interest
incorporating
bioactive
molecules
into
hydrogels.
This
article
investigates
how
these
infused
hydrogels
enhance
healing
process
chronic
wounds,
examining
various
loading
crosslinking
techniques
alongside
clinical
applications.
It
also
discusses
benefits
limitations
with
improve
strategies.
