Recent advances and perspectives in functional chitosan-based composites for environmental remediation, energy, and biomedical applications
Progress in Materials Science,
Год журнала:
2025,
Номер
unknown, С. 101460 - 101460
Опубликована: Фев. 1, 2025
Язык: Английский
An Antibacterial Hydrogel Based on Silk Sericin Cross-Linking Glycyrrhizic Acid and Silver for Infectious Wound Healing
Biomacromolecules,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 18, 2025
Bioactive
hydrogels
are
garnering
increasing
interest
in
wound
management
due
to
their
porous
structural
features
and
versatile
intrinsic
biological
activities.
Importantly,
the
antibacterial
capacity
is
a
crucial
requirement
for
hydrogel
dressings
chronically
infected
wounds.
In
this
study,
we
report
an
constructed
from
silk
sericin
(SS)
cross-linked
with
glycyrrhizic
acid
(GA)
integrated
silver
ions
(Ag+)
accelerate
healing
of
bacterial-infected
The
resultant
sericin-glycyrrhizic
acid-Ag+
(SGA)
demonstrates
favorable
mechanical
properties,
effectively
preventing
secondary
injury
Moreover,
vitro
studies
indicated
that
SGA
possesses
excellent
swelling
ratios,
degradability,
cytocompatibility,
promoting
cell
growth
proliferation.
Notably,
exhibited
effective
activity
against
both
Gram-positive
Gram-negative
bacteria
through
release
Ag+.
Staphylococcus
aureus-infected
model,
efficiently
eradicated
bacteria,
thus
repair.
Overall,
our
work
establishes
novel
strategy
developing
multifunctional
based
on
natural
materials
managing
bacteria-infected
Язык: Английский
Bioactive Nanoparticle‐Embedded Micro/Nanofibrous Dressing with Improved Angiogenesis and Immunoregulation for Facilitating Burn Wound Healing
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 4, 2024
Abstract
In
the
context
of
severe
burn
injuries,
presence
excessive
reactive
oxygen
species
(ROS),
prolonged
microbial
infection,
and
compromised
angiogenesis
can
contribute
to
metabolic
reprogramming
macrophages,
resulting
in
a
dysregulated
inflammatory
response
that
hinders
healing
process.
this
study,
cerium
oxide
nanoparticles
(CeNPs)
are
encapsulated
within
silk
fibroin‐poly(e‐caprolactone)
polymer
create
an
electrospun
PSF/CeNPs
nanofiber
membrane
(PSF/membrane).
This
is
further
modified
through
addition
angiopoietin‐1
mimetic
peptide,
QHREDGS,
formation
QPSF/CeNPs
(QHREDGS
membrane).
vitro
assessments
revealed
displayed
intended
ability
regulate
ROS
levels,
favorable
biocompatibility
with
cells,
promoted
endothelial
cell
attachment
growth,
exhibited
anti‐inflammatory
properties
modulation
macrophage
phenotypes
from
M1
M2,
as
well
pro‐angiogenetic
antibacterial
effects.
vivo,
dressing
demonstrated
acceleration
wound
healing,
promotion
angiogenesis,
downregulation
factors,
enhancement
collagen
deposition.
bioactive
shows
potential
clinical
therapy
for
promoting
regeneration
both
acute
chronically
damaged
skin
tissue.
Язык: Английский