Coordination engineering of FeCo dual single-atom nanozymes with photothermal-enhanced cascaded catalysis for efficient pancreatic cancer immunotherapy
Chemical Engineering Journal,
Год журнала:
2024,
Номер
496, С. 154203 - 154203
Опубликована: Июль 21, 2024
Язык: Английский
Electronic structure modulation of ultrathin PtRuMoCoNi high-entropy alloy nanowires for boosting peroxidase-like activity and sensitive colorimetric determination of isoniazid and hydrazine
Microchimica Acta,
Год журнала:
2025,
Номер
192(2)
Опубликована: Янв. 15, 2025
Язык: Английский
Organometallic-based pyroptotic inducers for cancer immunotherapy
Journal of Organometallic Chemistry,
Год журнала:
2025,
Номер
unknown, С. 123571 - 123571
Опубликована: Фев. 1, 2025
Язык: Английский
Functional Materials Targeted Regulation of Gasdermins: From Fundamentals to Functionalities and Applications
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 24, 2025
Abstract
Targeted
regulation
of
pyroptosis
to
modulate
the
immune
landscape
has
emerged
as
a
novel
design
strategy
for
cancer
immunotherapy
and
anti‐inflammatory
therapy.
However,
acts
double‐edged
sword,
making
it
important
optimize
strategies
functional
materials
appropriately
activate
effective
disease
treatment.
This
paper
summarizes
discusses
structure,
pore
formation,
molecular
mechanisms
“executor”
Gasdermins,
well
events
preceding
following
these
processes.
Subsequently,
focus
is
on
reviewing
that
directly
regulate
Gasdermin
formation
target
those
indirectly
before
after
control
activity.
Finally,
advantages,
disadvantages,
future
prospects
designing
such
are
provided,
aiming
facilitate
precise
design,
pharmacological
investigation,
clinical
translation
pyroptosis‐related
materials.
Язык: Английский
Mechanism of pesticide thiram reversibly inhibiting of Pt single-atom peroxidase-mimicking nanozyme and its application in colorimetric sensing thiram
Ziting Lin,
Guangze Sun,
Huan Liu
и другие.
Talanta,
Год журнала:
2025,
Номер
unknown, С. 128201 - 128201
Опубликована: Апрель 1, 2025
Язык: Английский
A Synergistic Dual‐Atom Sites Nanozyme Augments Immunogenic Cell Death for Efficient Immunotherapy
Advanced Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 24, 2024
Inducing
immunogenic
cell
death
(ICD)
is
a
promising
approach
to
elicit
enduring
antitumor
immune
responses.
Hence,
extensive
efforts
are
being
made
develop
ICD
inducers.
Herein,
cascaded
dual-atom
nanozyme
with
Fe
and
Cu
sites
(FeCu-DA)
as
an
efficient
inducer
presented.
The
synergistically
enhance
peroxidase
(POD)
catalase
activities,
effectively
converting
intratumoral
hydrogen
peroxide
(H
Язык: Английский
Au@Pd nanozyme-mediated catalytic therapy: a novel strategy for targeting tumor microenvironment in cancer treatment
Journal of Translational Medicine,
Год журнала:
2024,
Номер
22(1)
Опубликована: Сен. 2, 2024
Breast
cancer,
with
its
high
morbidity
and
mortality
rates,
is
a
significant
global
health
burden.
Traditional
treatments—surgery,
chemotherapy,
radiotherapy—are
widely
used
but
come
drawbacks
such
as
recurrence,
metastasis,
side
effects,
including
damage
to
healthy
tissues.
To
address
these
limitations,
new
therapeutic
strategies
are
being
developed.
Peroxidases
(POD)
can
catalyze
excess
H2O2
in
the
tumor
microenvironment
generate
reactive
oxygen
species
(ROS),
which
induce
cancer
cell
apoptosis
by
disrupting
redox
homeostasis
modulating
apoptosis-related
proteins.
However,
natural
enzymes
face
challenges
like
poor
stability,
cost,
sensitivity
environmental
conditions,
limiting
their
application
breast
treatment.
Nanozymes,
nanomaterials
enzyme-like
activity,
offer
promising
alternative
overcoming
limitations.
In
this
study,
we
successfully
prepared
Au@Pd
nanozymes
peroxidase
activity
depositing
metallic
Pd
on
Au
nanoparticles
(Au
NPs)
synthesized
using
trisodium
citrate
reduction
method
ascorbic
acid
reduction.
The
vitro
validation
was
conducted
through
series
of
experiments,
ROS
detection,
flow
cytometry,
CCK-8
assay,
DNA
assessment,
live/dead
staining,
Western
blot
(WB),
qPCR.
Tumor
treatment
performed
via
tail
vein
injection
drug,
followed
HE
staining
treated
tissues
biochemical
analysis
blood.
effectively
accumulate
at
site
EPR
effect
exert
peroxidase-like
catalyzing
produce
ROS.
This
triggers
pathways
damage,
leading
downregulation
anti-apoptotic
protein
Bcl-2,
upregulation
pro-apoptotic
Bax,
induction
genes,
demonstrating
strong
anti-tumor
effects.
study
developed
an
efficient
nanozyme-mediated
catalytic
therapy
strategy
targeting
for
cells.
Язык: Английский
Carbon-supported Fe single atom nanozymes with long-lasting ROS generation and high NIR photothermal performance for synergistic cancer therapy
Journal of Colloid and Interface Science,
Год журнала:
2024,
Номер
683, С. 1003 - 1014
Опубликована: Дек. 30, 2024
Язык: Английский
Nanomaterials evoke pyroptosis boosting cancer immunotherapy
Acta Pharmaceutica Sinica B,
Год журнала:
2024,
Номер
15(2), С. 852 - 875
Опубликована: Ноя. 23, 2024
Cancer
immunotherapy
is
currently
a
very
promising
therapeutic
strategy
for
treating
tumors.
However,
its
effectiveness
restricted
by
insufficient
antigenicity
and
an
immunosuppressive
tumor
microenvironment
(ITME).
Pyroptosis,
unique
form
of
programmed
cell
death
(PCD),
causes
cells
to
swell
rupture,
releasing
pro-inflammatory
factors
that
can
enhance
immunogenicity
remodel
the
ITME.
Nanomaterials,
with
their
distinct
advantages
different
techniques,
are
increasingly
popular,
nanomaterial-based
delivery
systems
demonstrate
significant
potential
potentiate,
enable,
augment
pyroptosis.
This
review
summarizes
discusses
emerging
field
nanomaterials-induced
pyroptosis,
focusing
on
mechanisms
pyroptosis
pathways
strategies
activate
or
specific
Additionally,
we
provide
perspectives
development
this
field,
aiming
accelerate
further
clinical
transition.
Язык: Английский