Cellulose, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 15, 2024
Язык: Английский
Materials & Design, Год журнала: 2024, Номер 243, С. 113091 - 113091
Опубликована: Июнь 14, 2024
Amidst the rapid advancements in materials science, exploration of aerogel-based biomaterials has garnered extensive attention across diverse sectors, including biomedicine, energy, architecture, and sensing. Comprehensive studies have unveiled utilization organic, inorganic, hybridized for aerogel preparation, catapulting to global prominence. Endowed with distinctive properties, low density, a hierarchical porous network, high porosity, nanoscale micropores, aerogels exhibited broad spectrum applications, particularly realm tissue engineering. The deployment engineering is dynamic phase development, available reports indicating varying degrees fields such as blood vessels, soft tissues, nerves, skin, muscles, heart, bronchial tubes, bone, cartilage—an evolutionary process. This paper offers comprehensive review evolution properties preparation processes, encapsulating strategic insights application It succinctly summarizes recent developments research, emphasizing their significance. Additionally, outlines future prospects envisions challenges arising from current studies. Through this thorough engineering, aspires make profound impact on regenerative medicine, offering innovative effective strategies biomedicine.
Язык: Английский
Процитировано
8
Journal of CO2 Utilization, Год журнала: 2024, Номер 81, С. 102722 - 102722
Опубликована: Март 1, 2024
Dry powder inhalers (DPIs) have gained increasing clinical acceptance in the local treatment of lung diseases due to their ability meet evolving needs patients while avoiding environmental concerns. However, some formulations for DPIs still encounter performance limitations terms aerodynamic properties and achievement therapeutic doses. Innovative aerogel processed using combined supercritical CO2 (scCO2)-based technologies can overcome these limitations, especially case poorly water-soluble drugs. The loading hydrophobic drugs into aerogels be optimized through a thorough understanding physicochemical formulation scCO2 processing conditions. In this study, drug-loaded alginate particles were prepared by combining gelation-emulsification techniques scCO2-based technologies. Beclomethasone dipropionate (BDP), corticosteroid, was incorporated matrix impregnation. influence contact time, initial amount drug, use co-solvents on efficiency impregnation studied. kinetics BDP adsorption process modelled elucidate time required drug attain equilibrium concentration under specific operating Nitrogen adsorption-desorption helium pycnometry revealed with large surface area (>200 m2/g) porosity (ca. 90%). resulting had excellent at relevant doses, as confirmed vitro deposition tests. Ex vivo permeability tests porcine tissues evidenced that released from inhaled could penetrate bronchial tissue.
Язык: Английский
Процитировано
4
Powder Technology, Год журнала: 2025, Номер unknown, С. 121048 - 121048
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Applied Surface Science Advances, Год журнала: 2025, Номер 27, С. 100765 - 100765
Опубликована: Май 9, 2025
Язык: Английский
Процитировано
0
Pharmaceuticals, Год журнала: 2024, Номер 17(12), С. 1628 - 1628
Опубликована: Дек. 4, 2024
Natural and synthetic biopolymers are gaining popularity in the development of inhaled drug formulations. Their highly tunable properties ability to sustain release allow for incorporation attributes not achieved dry powder inhaler formulations composed only micronized drugs, standard excipients, and/or carriers. There multiple physiological barriers penetration drugs epithelial surface, such as periciliary layer mucus mesh, pulmonary macrophages, inflammation compositional changes resulting from respiratory diseases. Biopolymers may facilitate transport surface despite barriers. A variety categories have been assessed their potential throughout research literature, ranging natural (e.g., chitosan, alginate, hyaluronic acid) those synthesized a laboratory setting polycaprolactone, poly(lactic-co-glycolic acid)) with varying structures compositions. To date, no approved commercial product. However, advances be possible treatment diseases infections upon further investigation evaluation. Herein, this review will provide thorough foundation reported utilizing Furthermore, insight considerations future proposed.
Язык: Английский
Процитировано
2
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 291, С. 139144 - 139144
Опубликована: Дек. 24, 2024
Язык: Английский
Процитировано
0
Cellulose, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 15, 2024
Язык: Английский
Процитировано
0