Multifunctional aerogel: A unique and advanced biomaterial for tissue regeneration and repair

Materials & Design, Journal Year: 2024, Volume and Issue: 243, P. 113091 - 113091

Published: June 14, 2024

Amidst the rapid advancements in materials science, exploration of aerogel-based biomaterials has garnered extensive attention across diverse sectors, including biomedicine, energy, architecture, and sensing. Comprehensive studies have unveiled utilization organic, inorganic, hybridized for aerogel preparation, catapulting to global prominence. Endowed with distinctive properties, low density, a hierarchical porous network, high porosity, nanoscale micropores, aerogels exhibited broad spectrum applications, particularly realm tissue engineering. The deployment engineering is dynamic phase development, available reports indicating varying degrees fields such as blood vessels, soft tissues, nerves, skin, muscles, heart, bronchial tubes, bone, cartilage—an evolutionary process. This paper offers comprehensive review evolution properties preparation processes, encapsulating strategic insights application It succinctly summarizes recent developments research, emphasizing their significance. Additionally, outlines future prospects envisions challenges arising from current studies. Through this thorough engineering, aspires make profound impact on regenerative medicine, offering innovative effective strategies biomedicine.

Language: Английский

---

Green CO2 technology for the preparation of aerogel dry powder loaded with beclomethasone dipropionate

Journal of CO2 Utilization, Journal Year: 2024, Volume and Issue: 81, P. 102722 - 102722

Published: March 1, 2024

Dry powder inhalers (DPIs) have gained increasing clinical acceptance in the local treatment of lung diseases due to their ability meet evolving needs patients while avoiding environmental concerns. However, some formulations for DPIs still encounter performance limitations terms aerodynamic properties and achievement therapeutic doses. Innovative aerogel processed using combined supercritical CO2 (scCO2)-based technologies can overcome these limitations, especially case poorly water-soluble drugs. The loading hydrophobic drugs into aerogels be optimized through a thorough understanding physicochemical formulation scCO2 processing conditions. In this study, drug-loaded alginate particles were prepared by combining gelation-emulsification techniques scCO2-based technologies. Beclomethasone dipropionate (BDP), corticosteroid, was incorporated matrix impregnation. influence contact time, initial amount drug, use co-solvents on efficiency impregnation studied. kinetics BDP adsorption process modelled elucidate time required drug attain equilibrium concentration under specific operating Nitrogen adsorption-desorption helium pycnometry revealed with large surface area (>200 m2/g) porosity (ca. 90%). resulting had excellent at relevant doses, as confirmed vitro deposition tests. Ex vivo permeability tests porcine tissues evidenced that released from inhaled could penetrate bronchial tissue.

Language: Английский

---

Simulation-based characterization of alginate aerogel packed bed compaction via DEM-BPM

Powder Technology, Journal Year: 2025, Volume and Issue: unknown, P. 121048 - 121048

Published: April 1, 2025

Language: Английский

---

Pristine and cross-linked gelatin aerogels of pH-responsive hydration and swelling

Applied Surface Science Advances, Journal Year: 2025, Volume and Issue: 27, P. 100765 - 100765

Published: May 9, 2025

Language: Английский

---

Biopolymeric Inhalable Dry Powders for Pulmonary Drug Delivery

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(12), P. 1628 - 1628

Published: Dec. 4, 2024

Natural and synthetic biopolymers are gaining popularity in the development of inhaled drug formulations. Their highly tunable properties ability to sustain release allow for incorporation attributes not achieved dry powder inhaler formulations composed only micronized drugs, standard excipients, and/or carriers. There multiple physiological barriers penetration drugs epithelial surface, such as periciliary layer mucus mesh, pulmonary macrophages, inflammation compositional changes resulting from respiratory diseases. Biopolymers may facilitate transport surface despite barriers. A variety categories have been assessed their potential throughout research literature, ranging natural (e.g., chitosan, alginate, hyaluronic acid) those synthesized a laboratory setting polycaprolactone, poly(lactic-co-glycolic acid)) with varying structures compositions. To date, no approved commercial product. However, advances be possible treatment diseases infections upon further investigation evaluation. Herein, this review will provide thorough foundation reported utilizing Furthermore, insight considerations future proposed.

Language: Английский

---

Bioaerogels produced from tempo oxidized nano cellulose with chitosan, gelatin, and alginate: general performances for wound dressing application

Cellulose, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 15, 2024

Language: Английский

---

Recent advances of bioaerogels in medicine: Preparation, property and application

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 291, P. 139144 - 139144

Published: Dec. 24, 2024

Language: Английский

---