Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер unknown, С. 106323 - 106323
Опубликована: Окт. 1, 2024
Язык: Английский
Biomolecules, Год журнала: 2024, Номер 14(7), С. 789 - 789
Опубликована: Июль 3, 2024
Alginate is a natural polymer with good biocompatible properties and potential polymeric material for the sustainable development replacement of petroleum derivatives. However, non-spinnability pure alginate solutions has hindered expansion applications. With continuous electrospinning technology, synthetic polymers, such as PEO PVA, are used co-spinning agents to increase spinnability alginate. Moreover, coaxial, parallel Janus, tertiary other diverse novel electrospun fiber structures prepared by multi-fluid have found new breakthrough problem poor spinning polymers. Meanwhile, effectively achieve multiple release modes drugs. The powerful combination electrostatic widely in many biomedical fields, tissue engineering, regenerative bioscaffolds, drug delivery, research fever continues climb. This particularly true controlled delivery aspect review provides brief overview alginate, introduces advances spinning, highlights progress alginate-based nanofibers achieving various modes, pulsed release, sustained biphasic responsive targeted release.
Язык: Английский
Процитировано
47
Nanocomposites, Год журнала: 2024, Номер 10(1), С. 240 - 253
Опубликована: Июнь 12, 2024
Язык: Английский
Процитировано
38
Frontiers in Bioengineering and Biotechnology, Год журнала: 2024, Номер 12
Опубликована: Июнь 13, 2024
Combination therapy with oral administration of several active ingredients is a popular clinical treatment for cancer. However, the traditional method has poor convenience, less safety, and low efficiency patients. The combination pharmaceutical techniques advanced material conversion methods can provide new solutions to this issue. In research, kind hybrid film was created via coaxial electrospraying, followed by casting process. films were composed Reglan 5-fluorouracil (5-FU)-loaded cellulose acetate (CA) core-shell particles in polyvinylpyrrolidone (PVP) matrix. Microscopic observations these demonstrated solid cross section loaded particles. X-ray diffraction Fourier-transform infrared tests verified that 5-FU showed amorphous states fine compatibilities polymeric matrices, i.e., PVP CA, respectively. vitro dissolution indicated able desired asynchronous dual-drug delivery, fast release Reglan, sustained 5-FU. controlled mechanisms shown be an erosion mechanism typical Fickian diffusion protocols reported herein pioneer approach fabricating biomaterials multiple drugs, each its own behavior, synergistic cancer treatment.
Язык: Английский
Процитировано
30
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(17), С. 9524 - 9524
Опубликована: Сен. 1, 2024
Core–shell nanostructures are powerful platforms for the development of novel nanoscale drug delivery systems with sustained release profiles. Coaxial electrospinning is facile and convenient creating medicated core–shell elaborate designs which sustained-release behaviors molecules can be intentionally adjusted. With resveratrol (RES) as a model poorly water-soluble cellulose acetate (CA) PVP polymeric carriers, brand-new electrospun nanostructure was fabricated in this study. The guest RES host CA were designed to have reverse gradient distribution within nanostructures. Scanning electron microscope transmission evaluations verified that these nanofibers had linear morphologies, without beads or spindles, an obvious double-chamber structure. X-ray diffraction patterns Fourier transform infrared spectroscopic results indicated involved components highly compatible presented amorphous molecular state. In vitro dissolution tests new structures able prevent initial burst release, extend continuous-release time period, reduce negative tailing-off effect, thus ensuring better profile than traditional blended drug-loaded nanofibers. mechanism underlying influence structure RES/CA on proposed. Based proof-of-concept demonstration, series advanced functional nanomaterials similarly developed based distributions multi-chamber
Язык: Английский
Процитировано
24
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 281, С. 135753 - 135753
Опубликована: Окт. 17, 2024
Язык: Английский
Процитировано
24
Langmuir, Год журнала: 2024, Номер 40(32), С. 16670 - 16689
Опубликована: Июнь 24, 2024
Waste polystyrene contributes considerably to environmental pollution due its persistent nature, prompting a widespread consensus on the urgent need for viable recycling solutions. Owing aromatic groups structure of polystyrene, hyper-cross-linked polymers can be synthesized through Friedel–Crafts cross-linking reaction using Lewis acids as catalysts. In addition, and carbonaceous counterparts used in several important applications, which helps their efficient recycling. This review systematically explores methods preparing multifunctional from waste applications sustainable We have comprehensively outlined various synthetic approaches these investigated physical chemical properties. These not only exhibit structural flexibility but also demonstrate diversity performance, making them suitable applications. Through systematic examination methods, we showcase cutting-edge positions materials field polymers. Additionally, provide in-depth insights into potential intentional recycling, highlighting contributions protection development. research provides valuable references fields science management, encouraging further exploration innovative utilization discarded polystyrene.
Язык: Английский
Процитировано
21
Polymers, Год журнала: 2024, Номер 16(18), С. 2614 - 2614
Опубликована: Сен. 15, 2024
Polymeric composites for manipulating the sustained release of an encapsulated active ingredient are highly sought after many practical applications; particularly, water-insoluble polymers and core–shell structures frequently explored to manipulate behaviors drug molecules over extended time period. In this study, electrospun nanostructures were utilized develop a brand-new strategy tailor spatial distributions both insoluble polymer (ethylcellulose, EC) soluble (polyvinylpyrrolidone, PVP) within nanofibers, thereby extended-release loaded ingredient, ferulic acid (FA). Scanning electron microscopy transmission assessments revealed that all prepared nanofibers had linear morphology without beads or spindles, those from coaxial processes obvious structure. X-ray diffraction attenuated total reflectance Fourier transform infrared spectroscopic tests confirmed FA fine compatibility with EC PVP, presented in amorphous state. vitro dissolution indicated radical (decreasing shell core) PVP (increasing able play their important role elaborately. On one hand, F3 advantages homogeneous composite F1 higher content solutions inhibit initial burst provide longer period release. other F2 core negative tailing-off The key element was water permeation rates, controlled by ratios polymers. new based on structure paves way developing wide variety polymeric heterogeneous realizing desired functional performances.
Язык: Английский
Процитировано
19
Journal of Food Science, Год журнала: 2024, Номер 89(11), С. 7803 - 7818
Опубликована: Окт. 8, 2024
Abstract Bio‐based active food packaging materials have a high market demand. We use coaxial electrospinning technology to prepare core–shell structured nanofibers with sustained antibacterial and antioxidant properties. The fiber core layer was composed of gelatin tea polyphenols, whereas polyphenols provide properties; the sheath pullulan polysaccharides By using scanning electron microscope, it can be seen that diameter distribution prepared uniform surface is smooth; transmission clearly structure; Fourier Transform Infrared X‐ray diffraction analysis indicate an amorphous 2,2‐diphenyl‐1‐picrylhydrazyl free radical scavenging shows higher properties addition polyphenols; test showed had obvious inhibitory effect on growth Staphylococcus aureus Escherichia coli ; nanofiber film dissolution used as fast soluble packaging. Finally, core–sheath‐structured serve for instant food, possessing both rapid water solubility excellent activity, making water‐soluble interesting applications in field
Язык: Английский
Процитировано
18
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(17), С. 9556 - 9556
Опубликована: Сен. 3, 2024
Personal protective equipment (PPE) has attracted more attention since the outbreak of epidemic in 2019. Advanced nano techniques, such as electrospinning, can provide new routes for developing novel PPE. However, electrospun antibacterial PPE is not easily obtained. Fibers loaded with photosensitizers prepared using single-fluid electrospinning have a relatively low utilization rate due to influence embedding and their inadequate mechanical properties. For this study, monolithic nanofibers core–shell were compared. Monolithic F1 fibers comprising polyethylene oxide (PEO), poly(vinyl alcohol-co-ethylene) (PVA-co-PE), photo-antibacterial agent vitamin K3 (VK3) created blending process. Core–shell F2 coaxial which extensible material PEO was set core section, composite consisting PEO, PVA-co-PE, VK3 shell section. Both designed structural properties had an average diameter approximately 1.0 μm, determined scanning electron microscopy transmission microscopy. amorphously dispersed within polymeric matrices compatible manner, revealed X-ray diffraction Fourier transform infrared spectroscopy. higher tensile strength 2.917 ± 0.091 MPa, whereas longer elongation break 194.567 0.091%. Photoreaction tests showed that, adjustment, could produce 0.222 μmol/L ·OH upon illumination. slightly better performance than fibers, inhibition zones 1.361 0.012 cm 1.296 0.022 E. coli S. aureus, respectively, but less VK3. The intentional tailoring components compositions nanostructures improve process–structure–performance relationship potential sunlight-activated
Язык: Английский
Процитировано
16
Chemical Engineering Journal, Год журнала: 2025, Номер 506, С. 160117 - 160117
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
6