ACS Applied Bio Materials,
Год журнала:
2024,
Номер
7(12), С. 8642 - 8655
Опубликована: Ноя. 12, 2024
A
promising
approach
for
wound
treatment
is
using
multilayer
dressings
that
offer
multifunctional
properties.
In
this
study,
a
bilayered
electrospun/hydrogel
gelatin-based
scaffold
integrated
with
honey
and
curcumin
was
developed
to
treat
wounds
under
an
in
vivo
study.
The
first
layer
consisted
of
enzymatic
cross-linked
gelatin
hydrogel
containing
curcumin,
which
gelatin/PCL
nanofibers
reinforced.
physicochemical,
mechanical,
biological
properties
both
layers
were
evaluated.
Then,
the
dressing
compared
commercial
results
showed
strategy
provided
strength
40
MPa,
70%
elongation,
800%
swelling
rate,
8
g/h/m2
water
vapor
permeability.
Furthermore,
MTT
histopathological
staining
demonstrated
promoted
closure
accelerated
collagen
production
tissue
granulation,
immune
system
response
re-epithelialization
other
groups.
presence
nanofibrous
on
surface
facilitated
its
use,
inclusion
prevented
adhesion
allowed
easy
replacement
without
damaging
bed.
Overall,
holds
great
potential
developing
dressings.
Biomolecules,
Год журнала:
2024,
Номер
14(7), С. 789 - 789
Опубликована: Июль 3, 2024
Alginate
is
a
natural
polymer
with
good
biocompatible
properties
and
potential
polymeric
material
for
the
sustainable
development
replacement
of
petroleum
derivatives.
However,
non-spinnability
pure
alginate
solutions
has
hindered
expansion
applications.
With
continuous
electrospinning
technology,
synthetic
polymers,
such
as
PEO
PVA,
are
used
co-spinning
agents
to
increase
spinnability
alginate.
Moreover,
coaxial,
parallel
Janus,
tertiary
other
diverse
novel
electrospun
fiber
structures
prepared
by
multi-fluid
have
found
new
breakthrough
problem
poor
spinning
polymers.
Meanwhile,
effectively
achieve
multiple
release
modes
drugs.
The
powerful
combination
electrostatic
widely
in
many
biomedical
fields,
tissue
engineering,
regenerative
bioscaffolds,
drug
delivery,
research
fever
continues
climb.
This
particularly
true
controlled
delivery
aspect
review
provides
brief
overview
alginate,
introduces
advances
spinning,
highlights
progress
alginate-based
nanofibers
achieving
various
modes,
pulsed
release,
sustained
biphasic
responsive
targeted
release.
Progress in Materials Science,
Год журнала:
2024,
Номер
147, С. 101350 - 101350
Опубликована: Авг. 6, 2024
Wound
healing
is
a
complex
biological
process
that,
when
impaired,
can
lead
to
the
formation
of
scars.
Electrospun
nanofibrous
wound
dressings
have
emerged
as
promising
option
for
promoting
scar-free
healing.
This
paper
explores
role
physical,
compositional,
and
chemical
cues,
each
contributing
remarkable
potential
these
dressings.
The
physical
properties
dressings,
such
porosity
mechanical
characteristics,
guide
cellular
behaviors
promote
vascularization,
fostering
conducive
environment
reduced
scarring.
Furthermore,
integration
natural
polymers
that
mimic
skin's
extracellular
matrix,
known
compositional
adds
another
layer
complexity
As
therapeutic
agents
demonstrated
their
combat
chronic
scenarios
leading
scar
formation.
However,
achieving
desired
effect
hinges
on
nature
controlled
release.
Therefore,
also
delves
into
various
loading
techniques
tailoring
release
profiles
bioactive
agents.
Although
electrospun
are
viable
commercial
product
remains
elusive.
gap
be
attributed
lack
comprehensive
in
vivo
studies,
particularly
animal
models
human
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(17), С. 9524 - 9524
Опубликована: Сен. 1, 2024
Core–shell
nanostructures
are
powerful
platforms
for
the
development
of
novel
nanoscale
drug
delivery
systems
with
sustained
release
profiles.
Coaxial
electrospinning
is
facile
and
convenient
creating
medicated
core–shell
elaborate
designs
which
sustained-release
behaviors
molecules
can
be
intentionally
adjusted.
With
resveratrol
(RES)
as
a
model
poorly
water-soluble
cellulose
acetate
(CA)
PVP
polymeric
carriers,
brand-new
electrospun
nanostructure
was
fabricated
in
this
study.
The
guest
RES
host
CA
were
designed
to
have
reverse
gradient
distribution
within
nanostructures.
Scanning
electron
microscope
transmission
evaluations
verified
that
these
nanofibers
had
linear
morphologies,
without
beads
or
spindles,
an
obvious
double-chamber
structure.
X-ray
diffraction
patterns
Fourier
transform
infrared
spectroscopic
results
indicated
involved
components
highly
compatible
presented
amorphous
molecular
state.
In
vitro
dissolution
tests
new
structures
able
prevent
initial
burst
release,
extend
continuous-release
time
period,
reduce
negative
tailing-off
effect,
thus
ensuring
better
profile
than
traditional
blended
drug-loaded
nanofibers.
mechanism
underlying
influence
structure
RES/CA
on
proposed.
Based
proof-of-concept
demonstration,
series
advanced
functional
nanomaterials
similarly
developed
based
distributions
multi-chamber
Polymers,
Год журнала:
2024,
Номер
16(18), С. 2614 - 2614
Опубликована: Сен. 15, 2024
Polymeric
composites
for
manipulating
the
sustained
release
of
an
encapsulated
active
ingredient
are
highly
sought
after
many
practical
applications;
particularly,
water-insoluble
polymers
and
core–shell
structures
frequently
explored
to
manipulate
behaviors
drug
molecules
over
extended
time
period.
In
this
study,
electrospun
nanostructures
were
utilized
develop
a
brand-new
strategy
tailor
spatial
distributions
both
insoluble
polymer
(ethylcellulose,
EC)
soluble
(polyvinylpyrrolidone,
PVP)
within
nanofibers,
thereby
extended-release
loaded
ingredient,
ferulic
acid
(FA).
Scanning
electron
microscopy
transmission
assessments
revealed
that
all
prepared
nanofibers
had
linear
morphology
without
beads
or
spindles,
those
from
coaxial
processes
obvious
structure.
X-ray
diffraction
attenuated
total
reflectance
Fourier
transform
infrared
spectroscopic
tests
confirmed
FA
fine
compatibility
with
EC
PVP,
presented
in
amorphous
state.
vitro
dissolution
indicated
radical
(decreasing
shell
core)
PVP
(increasing
able
play
their
important
role
elaborately.
On
one
hand,
F3
advantages
homogeneous
composite
F1
higher
content
solutions
inhibit
initial
burst
provide
longer
period
release.
other
F2
core
negative
tailing-off
The
key
element
was
water
permeation
rates,
controlled
by
ratios
polymers.
new
based
on
structure
paves
way
developing
wide
variety
polymeric
heterogeneous
realizing
desired
functional
performances.
Journal of Food Science,
Год журнала:
2024,
Номер
89(11), С. 7803 - 7818
Опубликована: Окт. 8, 2024
Abstract
Bio‐based
active
food
packaging
materials
have
a
high
market
demand.
We
use
coaxial
electrospinning
technology
to
prepare
core–shell
structured
nanofibers
with
sustained
antibacterial
and
antioxidant
properties.
The
fiber
core
layer
was
composed
of
gelatin
tea
polyphenols,
whereas
polyphenols
provide
properties;
the
sheath
pullulan
polysaccharides
By
using
scanning
electron
microscope,
it
can
be
seen
that
diameter
distribution
prepared
uniform
surface
is
smooth;
transmission
clearly
structure;
Fourier
Transform
Infrared
X‐ray
diffraction
analysis
indicate
an
amorphous
2,2‐diphenyl‐1‐picrylhydrazyl
free
radical
scavenging
shows
higher
properties
addition
polyphenols;
test
showed
had
obvious
inhibitory
effect
on
growth
Staphylococcus
aureus
Escherichia
coli
;
nanofiber
film
dissolution
used
as
fast
soluble
packaging.
Finally,
core–sheath‐structured
serve
for
instant
food,
possessing
both
rapid
water
solubility
excellent
activity,
making
water‐soluble
interesting
applications
in
field
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(17), С. 9556 - 9556
Опубликована: Сен. 3, 2024
Personal
protective
equipment
(PPE)
has
attracted
more
attention
since
the
outbreak
of
epidemic
in
2019.
Advanced
nano
techniques,
such
as
electrospinning,
can
provide
new
routes
for
developing
novel
PPE.
However,
electrospun
antibacterial
PPE
is
not
easily
obtained.
Fibers
loaded
with
photosensitizers
prepared
using
single-fluid
electrospinning
have
a
relatively
low
utilization
rate
due
to
influence
embedding
and
their
inadequate
mechanical
properties.
For
this
study,
monolithic
nanofibers
core–shell
were
compared.
Monolithic
F1
fibers
comprising
polyethylene
oxide
(PEO),
poly(vinyl
alcohol-co-ethylene)
(PVA-co-PE),
photo-antibacterial
agent
vitamin
K3
(VK3)
created
blending
process.
Core–shell
F2
coaxial
which
extensible
material
PEO
was
set
core
section,
composite
consisting
PEO,
PVA-co-PE,
VK3
shell
section.
Both
designed
structural
properties
had
an
average
diameter
approximately
1.0
μm,
determined
scanning
electron
microscopy
transmission
microscopy.
amorphously
dispersed
within
polymeric
matrices
compatible
manner,
revealed
X-ray
diffraction
Fourier
transform
infrared
spectroscopy.
higher
tensile
strength
2.917
±
0.091
MPa,
whereas
longer
elongation
break
194.567
0.091%.
Photoreaction
tests
showed
that,
adjustment,
could
produce
0.222
μmol/L
·OH
upon
illumination.
slightly
better
performance
than
fibers,
inhibition
zones
1.361
0.012
cm
1.296
0.022
E.
coli
S.
aureus,
respectively,
but
less
VK3.
The
intentional
tailoring
components
compositions
nanostructures
improve
process–structure–performance
relationship
potential
sunlight-activated
