Bioactive Nanoparticle‐Embedded Micro/Nanofibrous Dressing with Improved Angiogenesis and Immunoregulation for Facilitating Burn Wound Healing DOI

Lerong Yang,

Yong Wu, Bo Yang

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 4, 2024

Abstract In the context of severe burn injuries, presence excessive reactive oxygen species (ROS), prolonged microbial infection, and compromised angiogenesis can contribute to metabolic reprogramming macrophages, resulting in a dysregulated inflammatory response that hinders healing process. this study, cerium oxide nanoparticles (CeNPs) are encapsulated within silk fibroin‐poly(e‐caprolactone) polymer create an electrospun PSF/CeNPs nanofiber membrane (PSF/membrane). This is further modified through addition angiopoietin‐1 mimetic peptide, QHREDGS, formation QPSF/CeNPs (QHREDGS membrane). vitro assessments revealed displayed intended ability regulate ROS levels, favorable biocompatibility with cells, promoted endothelial cell attachment growth, exhibited anti‐inflammatory properties modulation macrophage phenotypes from M1 M2, as well pro‐angiogenetic antibacterial effects. vivo, dressing demonstrated acceleration wound healing, promotion angiogenesis, downregulation factors, enhancement collagen deposition. bioactive shows potential clinical therapy for promoting regeneration both acute chronically damaged skin tissue.

Language: Английский

Recent advances and perspectives in functional chitosan-based composites for environmental remediation, energy, and biomedical applications DOI
Yue Zhou, Yan Zhang,

Yingxia Nie

et al.

Progress in Materials Science, Journal Year: 2025, Volume and Issue: unknown, P. 101460 - 101460

Published: Feb. 1, 2025

Language: Английский

Citations

2
An Antibacterial Hydrogel Based on Silk Sericin Cross-Linking Glycyrrhizic Acid and Silver for Infectious Wound Healing DOI
Xiang Li, Yurong Li,

Akoumay Tehoungue

et al.

Biomacromolecules, Journal Year: 2025, Volume and Issue: unknown

Published: March 18, 2025

Bioactive hydrogels are garnering increasing interest in wound management due to their porous structural features and versatile intrinsic biological activities. Importantly, the antibacterial capacity is a crucial requirement for hydrogel dressings chronically infected wounds. In this study, we report an constructed from silk sericin (SS) cross-linked with glycyrrhizic acid (GA) integrated silver ions (Ag+) accelerate healing of bacterial-infected The resultant sericin-glycyrrhizic acid-Ag+ (SGA) demonstrates favorable mechanical properties, effectively preventing secondary injury Moreover, vitro studies indicated that SGA possesses excellent swelling ratios, degradability, cytocompatibility, promoting cell growth proliferation. Notably, exhibited effective activity against both Gram-positive Gram-negative bacteria through release Ag+. Staphylococcus aureus-infected model, efficiently eradicated bacteria, thus repair. Overall, our work establishes novel strategy developing multifunctional based on natural materials managing bacteria-infected

Language: Английский

Citations

0
Bioactive Nanoparticle‐Embedded Micro/Nanofibrous Dressing with Improved Angiogenesis and Immunoregulation for Facilitating Burn Wound Healing DOI

Lerong Yang,

Yong Wu, Bo Yang

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 4, 2024

Abstract In the context of severe burn injuries, presence excessive reactive oxygen species (ROS), prolonged microbial infection, and compromised angiogenesis can contribute to metabolic reprogramming macrophages, resulting in a dysregulated inflammatory response that hinders healing process. this study, cerium oxide nanoparticles (CeNPs) are encapsulated within silk fibroin‐poly(e‐caprolactone) polymer create an electrospun PSF/CeNPs nanofiber membrane (PSF/membrane). This is further modified through addition angiopoietin‐1 mimetic peptide, QHREDGS, formation QPSF/CeNPs (QHREDGS membrane). vitro assessments revealed displayed intended ability regulate ROS levels, favorable biocompatibility with cells, promoted endothelial cell attachment growth, exhibited anti‐inflammatory properties modulation macrophage phenotypes from M1 M2, as well pro‐angiogenetic antibacterial effects. vivo, dressing demonstrated acceleration wound healing, promotion angiogenesis, downregulation factors, enhancement collagen deposition. bioactive shows potential clinical therapy for promoting regeneration both acute chronically damaged skin tissue.

Language: Английский

Citations

2