Cascade Nanozyme-Loaded Sprayable Hydrogels for Fibroblast Rejuvenation and Diabetic Wound Regeneration

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Март 29, 2025

Multifunctional composite wound dressings hold significant promise for diabetic healing. However, the detrimental role of advanced glycation end-products (AGEs)-reactive oxygen species (ROS) cycle in impeding repair remains underexplored. To disrupt this pathological cycle, zeolitic imidazolate framework-8 (ZIF-8) encapsulated cerium dioxide (CeO2) and adsorbed glucose oxidase (GOx) nanozyme particles ((ZIF-8@CeO2)@GOx, zcg) were loaded into a methacrylic anhydride-modified gelatin (GelMA) hydrogel to form sprayable dressing, zcg/GelMA (zcgG). Physicochemical characterization revealed that GOx catalyzes oxidation, triggering ZIF-8 acid-mediated decomposition release zinc ions CeO2 nanoparticles, thereby enabling cascade depletion, antioxidant, antiglycation functions. In vitro antimicrobial cytotoxicity experiments optimized zcg concentration GelMA. Under oxidative hyperglycemic culture conditions, we validated mechanism blocking AGEs-ROS restoring fibroblast mitochondrial membrane potential, subsequently suppressing cellular senescence. bacterial-infected rat skin model, zcgG group demonstrated substantially reduced inflammatory levels, 68% decrease AGEs, 1.9-fold increase collagen deposition compared blank controls. Within 2 weeks, achieved complete closure, while control retained 28% initial area. This work provides preliminary evidence feasibility using nanozymes break promote

Язык: Английский

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Hesperidin-loaded self-assembled supramolecular hydrogel based on quaternized chitosan as efficient photothermal antibacterial dressing for MRSA-infected wound healing

Carbohydrate Polymers, Год журнала: 2025, Номер unknown, С. 123577 - 123577

Опубликована: Апрель 1, 2025

Язык: Английский

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Intelligent hydrogel-based dressings for treatment of chronic diabetic wounds

World Journal of Diabetes, Год журнала: 2025, Номер 16(5)

Опубликована: Апрель 24, 2025

Diabetic wounds represent a significant challenge in the medical field, significantly impacting patient quality of life and imposing heavy burden on healthcare systems. Intelligent hydrogel dressings have attracted attention diabetic wound treatment due to their unique properties. This review systematically explores three main categories intelligent hydrogels (natural, synthetic, composite), dissecting composition, structure, mechanisms that enable responses. The crucial roles these maintaining moist environment, efficiently absorbing exudate, precisely delivering drugs are expounded. Moreover, application advantages combating bacteria infections, regulating inflammation immunity, promoting angiogenesis tissue regeneration, as well enabling real-time monitoring personalized treatment, explored depth. Additionally, we discuss future research directions prospects for precision medicine care, aiming inspire innovation provide comprehensive theoretical basis development next-generation dressings.

Язык: Английский

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Bioactive hydrogel (ZIF-8@CMC-PVA-SA) as dressing materials for wound healing applications

Materials Today Communications, Год журнала: 2024, Номер 42, С. 111282 - 111282

Опубликована: Дек. 11, 2024

Язык: Английский

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Pullulan fermented by Aureobasidium melanogenum TZ-FC3 for the preparation of self-healing, adhesive, injectable and antibacterial pullulan/PVA/borax hydrogel

International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 138544 - 138544

Опубликована: Дек. 1, 2024

Язык: Английский

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Bioactive Matters based on Natural Product for Cardiovascular Diseases

Smart Materials in Medicine, Год журнала: 2024, Номер 5(4), С. 542 - 565

Опубликована: Ноя. 16, 2024

Язык: Английский

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