Cascade Nanozyme-Loaded Sprayable Hydrogels for Fibroblast Rejuvenation and Diabetic Wound Regeneration

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: March 29, 2025

Multifunctional composite wound dressings hold significant promise for diabetic healing. However, the detrimental role of advanced glycation end-products (AGEs)-reactive oxygen species (ROS) cycle in impeding repair remains underexplored. To disrupt this pathological cycle, zeolitic imidazolate framework-8 (ZIF-8) encapsulated cerium dioxide (CeO2) and adsorbed glucose oxidase (GOx) nanozyme particles ((ZIF-8@CeO2)@GOx, zcg) were loaded into a methacrylic anhydride-modified gelatin (GelMA) hydrogel to form sprayable dressing, zcg/GelMA (zcgG). Physicochemical characterization revealed that GOx catalyzes oxidation, triggering ZIF-8 acid-mediated decomposition release zinc ions CeO2 nanoparticles, thereby enabling cascade depletion, antioxidant, antiglycation functions. In vitro antimicrobial cytotoxicity experiments optimized zcg concentration GelMA. Under oxidative hyperglycemic culture conditions, we validated mechanism blocking AGEs-ROS restoring fibroblast mitochondrial membrane potential, subsequently suppressing cellular senescence. bacterial-infected rat skin model, zcgG group demonstrated substantially reduced inflammatory levels, 68% decrease AGEs, 1.9-fold increase collagen deposition compared blank controls. Within 2 weeks, achieved complete closure, while control retained 28% initial area. This work provides preliminary evidence feasibility using nanozymes break promote

Language: Английский

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Hesperidin-loaded self-assembled supramolecular hydrogel based on quaternized chitosan as efficient photothermal antibacterial dressing for MRSA-infected wound healing

Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: unknown, P. 123577 - 123577

Published: April 1, 2025

Language: Английский

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Intelligent hydrogel-based dressings for treatment of chronic diabetic wounds

World Journal of Diabetes, Journal Year: 2025, Volume and Issue: 16(5)

Published: April 24, 2025

Diabetic wounds represent a significant challenge in the medical field, significantly impacting patient quality of life and imposing heavy burden on healthcare systems. Intelligent hydrogel dressings have attracted attention diabetic wound treatment due to their unique properties. This review systematically explores three main categories intelligent hydrogels (natural, synthetic, composite), dissecting composition, structure, mechanisms that enable responses. The crucial roles these maintaining moist environment, efficiently absorbing exudate, precisely delivering drugs are expounded. Moreover, application advantages combating bacteria infections, regulating inflammation immunity, promoting angiogenesis tissue regeneration, as well enabling real-time monitoring personalized treatment, explored depth. Additionally, we discuss future research directions prospects for precision medicine care, aiming inspire innovation provide comprehensive theoretical basis development next-generation dressings.

Language: Английский

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Bioactive hydrogel (ZIF-8@CMC-PVA-SA) as dressing materials for wound healing applications

Materials Today Communications, Journal Year: 2024, Volume and Issue: 42, P. 111282 - 111282

Published: Dec. 11, 2024

Language: Английский

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Pullulan fermented by Aureobasidium melanogenum TZ-FC3 for the preparation of self-healing, adhesive, injectable and antibacterial pullulan/PVA/borax hydrogel

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 138544 - 138544

Published: Dec. 1, 2024

Language: Английский

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Bioactive Matters based on Natural Product for Cardiovascular Diseases

Smart Materials in Medicine, Journal Year: 2024, Volume and Issue: 5(4), P. 542 - 565

Published: Nov. 16, 2024

Language: Английский

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