Natural Protein-Based Multifunctional Hydrogel Dressing Formed by Rapid Photocuring and Zinc Ion Coordination to Accelerate Wound Healing
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 13, 2025
This
study
explores
the
use
of
chicken
egg
white
(EW),
a
rich
source
natural
proteins,
to
address
challenges
in
wound
healing
management.
Herein,
novel
Zn2+-infused
EW/GelMA
(EW/Gel)
hybrid
hydrogel
is
developed,
featuring
an
interpenetrating
network
(IPN)
structure,
where
first
consists
photo-cross-linked
GelMA
and
second
EW
(Zn-EW)
through
ion–protein
binding.
By
optimizing
design
formulation,
resulting
Zn-EW/Gel
exhibited
enhanced
mechanical
stability
self-adhesive
properties.
In
vitro
experiments
demonstrated
that
combined
effects
functional
proteins
active
ions
within
promote
fibroblast
proliferation
type
I
collagen
expression,
modulate
immune
microenvironment,
enhance
angiogenesis.
The
also
excellent
biocompatibility
bioactivity
vivo,
showing
strong
promise
for
restoring
physiological
properties
damaged
tissue.
Язык: Английский
Novel Polyethyleneimine-chitosan Nanoparticles Encapsulating Urolithin B: A Potential Nanotherapeutic Approach for Diabetic Nephropathy
Journal of Cluster Science,
Год журнала:
2025,
Номер
36(2)
Опубликована: Фев. 2, 2025
Язык: Английский
H2S/Curcumin Coreleasing Biomineralized Zinc Sulfide Nanostructures for Diabetic Wound Healing
ACS Applied Nano Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 23, 2025
Язык: Английский
Intelligent hydrogel-based dressings for treatment of chronic diabetic wounds
World Journal of Diabetes,
Год журнала:
2025,
Номер
16(5)
Опубликована: Апрель 24, 2025
Diabetic
wounds
represent
a
significant
challenge
in
the
medical
field,
significantly
impacting
patient
quality
of
life
and
imposing
heavy
burden
on
healthcare
systems.
Intelligent
hydrogel
dressings
have
attracted
attention
diabetic
wound
treatment
due
to
their
unique
properties.
This
review
systematically
explores
three
main
categories
intelligent
hydrogels
(natural,
synthetic,
composite),
dissecting
composition,
structure,
mechanisms
that
enable
responses.
The
crucial
roles
these
maintaining
moist
environment,
efficiently
absorbing
exudate,
precisely
delivering
drugs
are
expounded.
Moreover,
application
advantages
combating
bacteria
infections,
regulating
inflammation
immunity,
promoting
angiogenesis
tissue
regeneration,
as
well
enabling
real-time
monitoring
personalized
treatment,
explored
depth.
Additionally,
we
discuss
future
research
directions
prospects
for
precision
medicine
care,
aiming
inspire
innovation
provide
comprehensive
theoretical
basis
development
next-generation
dressings.
Язык: Английский
Construction of multifunctional hydrogel containing pH-responsive gold nanozyme for bacteria-infected wound healing
International Journal of Biological Macromolecules,
Год журнала:
2024,
Номер
unknown, С. 137746 - 137746
Опубликована: Ноя. 1, 2024
Язык: Английский
Dandelion-shaped strontium-gallium microparticles for the hierarchical stimulation and comprehensive regulation of wound healing
Regenerative Biomaterials,
Год журнала:
2024,
Номер
11
Опубликована: Янв. 1, 2024
Abstract
The
management
of
full-thickness
skin
injuries
continues
to
pose
significant
challenges.
Currently,
there
is
a
dearth
comprehensive
dressings
capable
integrating
all
stages
wound
healing
spatiotemporally
regulate
biological
processes
following
injuries.
In
this
study,
we
report
the
synthesis
dandelion-shaped
mesoporous
strontium-gallium
microparticle
(GE@SrTPP)
achieved
through
dopamine-mediated
strontium
ion
biomineralization
and
self-assembly,
followed
by
functionalization
with
gallium
metal
polyphenol
networks.
As
multifunctional
dressing,
GE@SrTPP
can
release
bioactive
ions
in
spatiotemporal
manner
akin
dandelion
seeds.
During
early
healing,
demonstrates
rapid
effective
hemostatic
performance
while
also
exhibiting
antibacterial
properties.
inflammatory
phase,
promotes
M2
polarization
macrophages,
suppresses
expression
pro-inflammatory
factors,
decreases
oxidative
stress
wounds.
Subsequently,
during
proliferation
tissue
remodeling,
facilitates
angiogenesis
activation
Hypoxia-inducible
factor-1α/vascular
endothelial
growth
factor
(HIF-1α/VEGF)
pathway.
Analogous
dispersion
rooting
seeds,
root-like
new
blood
vessels
supply
essential
nutrients
for
healing.
Ultimately,
rat
chronic
model,
successful
repair.
summary,
these
microparticles
demonstrate
regulatory
effects
managing
wounds,
making
them
highly
promising
materials
clinical
applications.
Язык: Английский