Dandelion-shaped strontium-gallium microparticles for the hierarchical stimulation and comprehensive regulation of wound healing DOI Creative Commons

Minrui Ji,

Zaixin Yuan,

Hongdong Ma

et al.

Regenerative Biomaterials, Journal Year: 2024, Volume and Issue: 11

Published: Jan. 1, 2024

Abstract The management of full-thickness skin injuries continues to pose significant challenges. Currently, there is a dearth comprehensive dressings capable integrating all stages wound healing spatiotemporally regulate biological processes following injuries. In this study, we report the synthesis dandelion-shaped mesoporous strontium-gallium microparticle (GE@SrTPP) achieved through dopamine-mediated strontium ion biomineralization and self-assembly, followed by functionalization with gallium metal polyphenol networks. As multifunctional dressing, GE@SrTPP can release bioactive ions in spatiotemporal manner akin dandelion seeds. During early healing, demonstrates rapid effective hemostatic performance while also exhibiting antibacterial properties. inflammatory phase, promotes M2 polarization macrophages, suppresses expression pro-inflammatory factors, decreases oxidative stress wounds. Subsequently, during proliferation tissue remodeling, facilitates angiogenesis activation Hypoxia-inducible factor-1α/vascular endothelial growth factor (HIF-1α/VEGF) pathway. Analogous dispersion rooting seeds, root-like new blood vessels supply essential nutrients for healing. Ultimately, rat chronic model, successful repair. summary, these microparticles demonstrate regulatory effects managing wounds, making them highly promising materials clinical applications.

Language: Английский

Natural Protein-Based Multifunctional Hydrogel Dressing Formed by Rapid Photocuring and Zinc Ion Coordination to Accelerate Wound Healing DOI
Qiujiang Li, Mengmeng Jin, Dan Sun

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

This study explores the use of chicken egg white (EW), a rich source natural proteins, to address challenges in wound healing management. Herein, novel Zn2+-infused EW/GelMA (EW/Gel) hybrid hydrogel is developed, featuring an interpenetrating network (IPN) structure, where first consists photo-cross-linked GelMA and second EW (Zn-EW) through ion–protein binding. By optimizing design formulation, resulting Zn-EW/Gel exhibited enhanced mechanical stability self-adhesive properties. In vitro experiments demonstrated that combined effects functional proteins active ions within promote fibroblast proliferation type I collagen expression, modulate immune microenvironment, enhance angiogenesis. The also excellent biocompatibility bioactivity vivo, showing strong promise for restoring physiological properties damaged tissue.

Language: Английский

Citations

1
Novel Polyethyleneimine-chitosan Nanoparticles Encapsulating Urolithin B: A Potential Nanotherapeutic Approach for Diabetic Nephropathy DOI

Jose Prakash Dharmian,

S. P. Angelin Claret,

P. Ramakrishnan

et al.

Journal of Cluster Science, Journal Year: 2025, Volume and Issue: 36(2)

Published: Feb. 2, 2025

Language: Английский

Citations

0
H2S/Curcumin Coreleasing Biomineralized Zinc Sulfide Nanostructures for Diabetic Wound Healing DOI

Shiqi Wu,

Yuxuan Ge,

Yuan Peng

et al.

ACS Applied Nano Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 23, 2025

Language: Английский

Citations

0
Intelligent hydrogel-based dressings for treatment of chronic diabetic wounds DOI
Chenguang Liu,

Li He

World Journal of Diabetes, Journal Year: 2025, Volume and Issue: 16(5)

Published: April 24, 2025

Diabetic wounds represent a significant challenge in the medical field, significantly impacting patient quality of life and imposing heavy burden on healthcare systems. Intelligent hydrogel dressings have attracted attention diabetic wound treatment due to their unique properties. This review systematically explores three main categories intelligent hydrogels (natural, synthetic, composite), dissecting composition, structure, mechanisms that enable responses. The crucial roles these maintaining moist environment, efficiently absorbing exudate, precisely delivering drugs are expounded. Moreover, application advantages combating bacteria infections, regulating inflammation immunity, promoting angiogenesis tissue regeneration, as well enabling real-time monitoring personalized treatment, explored depth. Additionally, we discuss future research directions prospects for precision medicine care, aiming inspire innovation provide comprehensive theoretical basis development next-generation dressings.

Language: Английский

Citations

0
Construction of multifunctional hydrogel containing pH-responsive gold nanozyme for bacteria-infected wound healing DOI
Jinfeng Peng, Chang Liu, Meilan Mo

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 137746 - 137746

Published: Nov. 1, 2024

Language: Английский

Citations

3
Dandelion-shaped strontium-gallium microparticles for the hierarchical stimulation and comprehensive regulation of wound healing DOI Creative Commons

Minrui Ji,

Zaixin Yuan,

Hongdong Ma

et al.

Regenerative Biomaterials, Journal Year: 2024, Volume and Issue: 11

Published: Jan. 1, 2024

Abstract The management of full-thickness skin injuries continues to pose significant challenges. Currently, there is a dearth comprehensive dressings capable integrating all stages wound healing spatiotemporally regulate biological processes following injuries. In this study, we report the synthesis dandelion-shaped mesoporous strontium-gallium microparticle (GE@SrTPP) achieved through dopamine-mediated strontium ion biomineralization and self-assembly, followed by functionalization with gallium metal polyphenol networks. As multifunctional dressing, GE@SrTPP can release bioactive ions in spatiotemporal manner akin dandelion seeds. During early healing, demonstrates rapid effective hemostatic performance while also exhibiting antibacterial properties. inflammatory phase, promotes M2 polarization macrophages, suppresses expression pro-inflammatory factors, decreases oxidative stress wounds. Subsequently, during proliferation tissue remodeling, facilitates angiogenesis activation Hypoxia-inducible factor-1α/vascular endothelial growth factor (HIF-1α/VEGF) pathway. Analogous dispersion rooting seeds, root-like new blood vessels supply essential nutrients for healing. Ultimately, rat chronic model, successful repair. summary, these microparticles demonstrate regulatory effects managing wounds, making them highly promising materials clinical applications.

Language: Английский

Citations

0