Bioadhesives and bioactive hydrogels for wound management

Journal of Controlled Release, Год журнала: 2025, Номер 379, С. 285 - 302

Опубликована: Янв. 13, 2025

Язык: Английский

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Recent advances in sonodynamic-derived synergistic strategies against bacterial infections

Chemical Engineering Journal, Год журнала: 2025, Номер 508, С. 160962 - 160962

Опубликована: Фев. 25, 2025

Язык: Английский

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Combined Chemo- and Photothermal Therapies of Non-Small Cell Lung Cancer Using Polydopamine/Au Hollow Nanospheres Loaded with Doxorubicin

International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 9597 - 9612

Опубликована: Сен. 1, 2024

The chemotherapeutic agent doxorubicin (DOX) is limited by its cardiotoxicity, posing challenges in application for non-small cell lung cancer (NSCLC). This study aims to explore the efficacy of polydopamine/Au nanoparticles loaded with DOX chemotherapy and photothermal therapy NSCLC achieve enhanced reduced toxicity.

Язык: Английский

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Dual ROS/Glucose-Responsive Quercetin-Loaded Supramolecular Hydrogel for Diabetic Wound Healing

Biomacromolecules, Год журнала: 2025, Номер unknown

Опубликована: Фев. 5, 2025

Diabetic wound healing remains a significant challenge due to complex pathological mechanisms, including prolonged inflammation, excessive reactive oxygen species (ROS) accumulation, angiogenesis dysfunction, and increased susceptibility bacterial infection. In this study, we developed dual ROS/glucose-responsive quercetin-loaded supramolecular hydrogel (GPQ hydrogel) for treating diabetic wounds. The was fabricated by incorporating quercetin (QUE) into guanosine–phenylboronic acid (GP) network through dynamic borate ester bonds. Structural characterization revealed the formation of typical G-quadruplex structure in GPQ hydrogel. responsiveness ROS glucose enabled controlled release QUE, effectively addressing abnormal microenvironment diabetes. vitro studies demonstrated excellent antibacterial, antioxidant, anti-inflammatory, pro-angiogenic properties Furthermore, vivo study using full-thickness model streptozotocin-induced rats showed that significantly accelerated closure, enhanced re-epithelialization collagen deposition, promoted compared control GP groups. Immunofluorescence analysis confirmed superior antioxidant effects microenvironment. This presents promising multifunctional biomaterial managing

Язык: Английский

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Shape-recoverable chitosan/sodium alginate aerogels with sustained oxygen release and antibacterial activity for diabetic wound healing

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 305, С. 141005 - 141005

Опубликована: Фев. 16, 2025

Язык: Английский

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Iron(III)‐Based Triple Network High‐Strength Low‐Swelling Hydrogel

ChemistrySelect, Год журнала: 2025, Номер 10(10)

Опубликована: Март 1, 2025

Abstract In this study, a tough chitosan‐gelatin‐polyacrylamide‐Fe 3+ (CGPA‐Fe ) hydrogel with triple‐network structure is successfully synthesized using photoinitiated free‐radical polymerization. The designed to achieve high‐strength, low‐swelling material suitable for biomedical applications. Experimental results demonstrate that the CGPA‐Fe exhibits excellent mechanical properties, compressive stress of 5.29 MPa and modulus 1.27 under 80% strain. Furthermore, shows outstanding fatigue resistance, retaining nearly 100% its peak after 10 compression cycles. It also displays remarkable self‐recovery capabilities, an energy dissipation recovery rate exceeding 85% 60‐s rest period. Regarding swelling behavior, demonstrates stability, further highlighting potential structural summary, represents promising candidate materials. This study provides novel approach strategy designing advanced hydrogels superior performance stability.

Язык: Английский

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Recent Development of Fibrous Hydrogels: Properties, Applications and Perspectives

Advanced Science, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 12, 2024

Fibrous hydrogels (FGs), characterized by a 3D network structure made from prefabricated fibers, fibrils and polymeric materials, have emerged as significant materials in numerous fields. However, the challenge of balancing mechanical properties functions hinders their further development. This article reviews main advantages FGs, including enhanced properties, high conductivity, antimicrobial anti-inflammatory stimulus responsiveness, an extracellular matrix (ECM)-like structure. It also discusses influence assembly methods, such fiber cross-linking, interfacial treatments fibers with hydrogel matrices, supramolecular assembly, on diverse functionalities FGs. Furthermore, mechanisms for improving performance above five aspects are discussed, creating ion carrier channels situ gelation drugs to enhance antibacterial entanglement hydrophobic interactions between resulting ECM-like structured In addition, this review addresses application FGs sensors, dressings, tissue scaffolds based synergistic effects optimizing performance. Finally, challenges future applications providing theoretical foundation new insights design cutting-edge

Язык: Английский

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An antimicrobial and adhesive conductive chitosan quaternary ammonium salt hydrogel dressing for combined electrical stimulation and photothermal treatment to promote wound healing

Carbohydrate Polymers, Год журнала: 2024, Номер 351, С. 123136 - 123136

Опубликована: Дек. 11, 2024

Язык: Английский

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Precise Photothermal Treatment of Bacterial Infection Mediated by Charge-Switchable Nanoplatform with Acylsulfonamide Betaine Surface

Colloids and Surfaces B Biointerfaces, Год журнала: 2024, Номер 245, С. 114362 - 114362

Опубликована: Ноя. 5, 2024

Язык: Английский

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Carrier-free porphyrin-based supramolecular complexes for near-infrared photothermal-enhanced wound healing

Chemical Engineering Journal, Год журнала: 2024, Номер unknown, С. 158128 - 158128

Опубликована: Ноя. 1, 2024

Язык: Английский

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