Epigenetic plasticity and the hallmarks of cancer

Science, Год журнала: 2017, Номер 357(6348)

Опубликована: Июль 20, 2017

Cancer epigenetics in the driver's seat Recent cancer genome projects unexpectedly highlighted role of epigenetic alterations development. About half human cancers were found to harbor mutations chromatin proteins. In a Review, Flavahan et al. propose that and aberrations have potential confer on cells full range oncogenic properties represented classic “hallmarks” depiction cancer. They suggest genetic, environmental, metabolic factors can make aberrantly permissive or restrictive. Permissive creates state “epigenetic plasticity,” which activate oncogene expression cell fate changes drive Science , this issue p. eaal2380

Язык: Английский

---

Cytoplasmic chromatin triggers inflammation in senescence and cancer

Nature, Год журнала: 2017, Номер 550(7676), С. 402 - 406

Опубликована: Окт. 1, 2017

Язык: Английский

---

Idiopathic pulmonary fibrosis

Nature Reviews Disease Primers, Год журнала: 2017, Номер 3(1)

Опубликована: Окт. 19, 2017

Язык: Английский

---

Biomolecular condensates at the nexus of cellular stress, protein aggregation disease and ageing

Nature Reviews Molecular Cell Biology, Год журнала: 2021, Номер 22(3), С. 196 - 213

Опубликована: Янв. 28, 2021

Язык: Английский

---

In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming

Cell, Год журнала: 2016, Номер 167(7), С. 1719 - 1733.e12

Опубликована: Дек. 1, 2016

Язык: Английский

---

Aging and aging-related diseases: from molecular mechanisms to interventions and treatments

Signal Transduction and Targeted Therapy, Год журнала: 2022, Номер 7(1)

Опубликована: Дек. 16, 2022

Aging is a gradual and irreversible pathophysiological process. It presents with declines in tissue cell functions significant increases the risks of various aging-related diseases, including neurodegenerative cardiovascular metabolic musculoskeletal immune system diseases. Although development modern medicine has promoted human health greatly extended life expectancy, aging society, variety chronic diseases have gradually become most important causes disability death elderly individuals. Current research on focuses elucidating how endogenous exogenous stresses (such as genomic instability, telomere dysfunction, epigenetic alterations, loss proteostasis, compromise autophagy, mitochondrial cellular senescence, stem exhaustion, altered intercellular communication, deregulated nutrient sensing) participate regulation aging. Furthermore, thorough pathogenesis to identify interventions that promote longevity caloric restriction, microbiota transplantation, nutritional intervention) clinical treatment methods for (depletion senescent cells, therapy, antioxidative anti-inflammatory treatments, hormone replacement therapy) could decrease incidence turn healthy longevity.

Язык: Английский

---

Unmasking senescence: context-dependent effects of SASP in cancer

Nature reviews. Cancer, Год журнала: 2019, Номер 19(8), С. 439 - 453

Опубликована: Июнь 24, 2019

Язык: Английский

---

Reprogramming to recover youthful epigenetic information and restore vision

Nature, Год журнала: 2020, Номер 588(7836), С. 124 - 129

Опубликована: Дек. 2, 2020

Язык: Английский

---

Benefits of Metformin in Attenuating the Hallmarks of Aging

Cell Metabolism, Год журнала: 2020, Номер 32(1), С. 15 - 30

Опубликована: Апрель 24, 2020

Язык: Английский

---

Mitochondrial dysfunction in cell senescence and aging

Journal of Clinical Investigation, Год журнала: 2022, Номер 132(13)

Опубликована: Июнь 30, 2022

Mitochondrial dysfunction and cell senescence are hallmarks of aging closely interconnected. dysfunction, operationally defined as a decreased respiratory capacity per mitochondrion together with mitochondrial membrane potential, typically accompanied by increased production oxygen free radicals, is cause consequence cellular figures prominently in multiple feedback loops that induce maintain the senescent phenotype. Here, we summarize pathways discuss major consequences how these contribute to aging. We also highlight potential senescence-associated an antiaging antisenescence intervention target, proposing combination interventions converging onto novel, potent senolytics.

Язык: Английский

---