Ageing Research Reviews, Год журнала: 2025, Номер 104, С. 102657 - 102657
Опубликована: Янв. 7, 2025
Язык: Английский
Science China Life Sciences, Год журнала: 2023, Номер 66(5), С. 893 - 1066
Опубликована: Апрель 11, 2023
Язык: Английский
Процитировано
194
Molecular Metabolism, Год журнала: 2023, Номер 74, С. 101755 - 101755
Опубликована: Июнь 16, 2023
Recently, the hallmarks of aging were updated to include dysbiosis, disabled macroautophagy, and chronic inflammation. In particular, low-grade inflammation during aging, without overt infection, is defined as "inflammaging," which associated with increased morbidity mortality in population. Emerging evidence suggests a bidirectional cyclical relationship between development age-related conditions, such cardiovascular diseases, neurodegeneration, cancer, frailty. How crosstalk other underlies biological mechanisms disease thus particular interest current geroscience research.
Язык: Английский
Процитировано
144
Ageing Research Reviews, Год журнала: 2023, Номер 88, С. 101955 - 101955
Опубликована: Май 15, 2023
Язык: Английский
Процитировано
134
Frontiers in Public Health, Год журнала: 2023, Номер 11
Опубликована: Окт. 13, 2023
Aging is a progressive and irreversible pathophysiological process that manifests as the decline in tissue cellular functions, along with significant increase risk of various aging-related diseases, including metabolic diseases. While advances modern medicine have significantly promoted human health extended lifespan, diseases such obesity type 2 diabetes among older adults pose major challenge to global public societies age. Therefore, understanding complex interaction between factors crucial for promoting well-being healthy aging. This review article explores environmental behavioral associated their impact on The environment, an obesogenic environment exposure toxins, strongly correlated rising prevalence its comorbidities. Behavioral factors, diet, physical activity, smoking, alcohol consumption, sleep patterns, influence throughout Public interventions targeting modifiable can effectively promote healthier lifestyles prevent Collaboration government agencies, healthcare providers community organizations essential implementing these creating supportive environments foster
Язык: Английский
Процитировано
55
European Journal of Pharmacology, Год журнала: 2023, Номер 944, С. 175584 - 175584
Опубликована: Фев. 11, 2023
Язык: Английский
Процитировано
54
ACS Chemical Neuroscience, Год журнала: 2023, Номер 15(1), С. 1 - 30
Опубликована: Дек. 14, 2023
Aging is a dynamic, time-dependent process that characterized by gradual accumulation of cell damage. Continual functional decline in the intrinsic ability living organisms to accurately regulate homeostasis leads increased susceptibility and vulnerability diseases. Many efforts have been put forth understand prevent effects aging. Thus, major cellular molecular hallmarks aging identified, their relationships age-related diseases malfunctions explored. Here, we use data from CAS Content Collection analyze publication landscape recent aging-related research. We review advances knowledge delineate trends research advancements on factors attributes across time geography. also current concepts related molecular, cellular, organismic level, age-associated diseases, with attention brain health, as well biochemical processes associated Major outlined, correlations features are hope this will be helpful for apprehending field mechanisms progression, an effort further solve remaining challenges fulfill its potential.
Язык: Английский
Процитировано
53
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(5), С. 4491 - 4491
Опубликована: Фев. 24, 2023
The life expectancy of the global population has increased. Aging is a natural physiological process that poses major challenges in an increasingly long-lived and frail population. Several molecular mechanisms are involved aging. Likewise, gut microbiota, which influenced by environmental factors such as diet, plays crucial role modulation these mechanisms. Mediterranean well components present it, offer some proof this. Achieving healthy aging should be focused on promotion lifestyle habits reduce development pathologies associated with aging, order to increase quality In this review we analyze influence diet pathways microbiota more favorable patterns, its possible anti-aging treatment.
Язык: Английский
Процитировано
50
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(4), С. 3658 - 3658
Опубликована: Фев. 11, 2023
Senescence is a cellular aging process in all multicellular organisms. It characterized by decay functions and proliferation, resulting increased damage death. This condition plays an essential role the significantly contributes to development of age-related complications. On other hand, ferroptosis systemic cell death pathway excessive iron accumulation followed generation reactive oxygen species (ROS). Oxidative stress common trigger this may be induced various factors such as toxins, drugs, inflammation. Ferroptosis linked numerous disorders, including cardiovascular disease, neurodegeneration, cancer. believed contribute tissue organ occurring with aging. has also been pathologies, diseases, diabetes, In particular, senescent cells have shown produce inflammatory cytokines pro-inflammatory molecules that can these conditions. turn, health known play pathologies promoting damaged or diseased contributing inflammation often associated. Both senescence are complex pathways still not fully understood. Further research needed thoroughly investigate processes identify potential interventions target order prevent treat systematic review aims assess mechanisms underlying link connecting senescence, ferroptosis, aging, whether they exploited block limit physiological elderly people for healthy longevity.
Язык: Английский
Процитировано
45
Cell, Год журнала: 2024, Номер 187(22), С. 6358 - 6378.e29
Опубликована: Сен. 12, 2024
Язык: Английский
Процитировано
44
Antioxidants, Год журнала: 2024, Номер 13(8), С. 985 - 985
Опубликована: Авг. 14, 2024
Gut dysbiosis, resulting from an imbalance in the gut microbiome, can induce excessive production of reactive oxygen species (ROS), leading to inflammation, DNA damage, activation immune system, and epigenetic alterations critical genes involved metabolic pathways. dysbiosis-induced inflammation also disrupt barrier integrity increase intestinal permeability, which allows gut-derived toxic products enter liver systemic circulation, further triggering oxidative stress, associated with diseases. However, specific metabolites, such as short-chain fatty acids (SCFAs), lactate, vitamins, modulate stress system through mechanisms, thereby improving function. microbiota diet-induced diseases, obesity, insulin resistance, dyslipidemia, hypertension, transfer next generation, involving mechanisms. In this review, we will introduce key that, along dysbiosis ROS, are engaged developing Finally, discuss potential therapeutic interventions dietary modifications, prebiotics, probiotics, postbiotics, fecal transplantation, may reduce syndrome by altering alterations. summary, review highlights crucial role pathogenesis a particular focus on (including histone methylomics, RNA interference) that prevent or improve
Язык: Английский
Процитировано
40