Scientific Reports,
Год журнала:
2022,
Номер
12(1)
Опубликована: Апрель 19, 2022
Abstract
Environmental
toxicants
have
been
shown
to
promote
the
epigenetic
transgenerational
inheritance
of
disease
through
exposure
specific
alterations
in
germline.
The
current
study
examines
actions
hydrocarbon
jet
fuel,
dioxin,
pesticides
(permethrin
and
methoxychlor),
plastics,
herbicides
(glyphosate
atrazine)
promotion
great
grand-offspring
rats
that
correlates
with
associated
differential
DNA
methylation
regions
(DMRs).
observed
was
similar
for
all
exposures
includes
pathologies
kidney,
prostate,
testis,
pubertal
abnormalities,
obesity.
DMRs
sperm
were
each
pathology
negligible
overlap.
Therefore,
genes
distinct
generational
lineage.
Observations
suggest
a
large
number
are
involved
pathology,
various
environmental
influence
unique
subsets
developmental
origins
susceptibility
later
life.
A
novel
multiscale
systems
biology
basis
etiology
is
proposed
involving
an
integration
epigenetics,
genetics
toxicology.
Hypertension,
Год журнала:
2024,
Номер
81(6), С. 1218 - 1232
Опубликована: Март 21, 2024
Inflammatory
responses
in
small
vessels
play
an
important
role
the
development
of
cardiovascular
diseases,
including
hypertension,
stroke,
and
vessel
disease.
This
involves
various
complex
molecular
processes
oxidative
stress,
inflammasome
activation,
immune-mediated
responses,
protein
misfolding,
which
together
contribute
to
microvascular
damage.
In
addition,
epigenetic
factors,
DNA
methylation,
histone
modifications,
microRNAs
influence
vascular
inflammation
injury.
These
phenomena
may
be
acquired
during
aging
process
or
due
environmental
factors.
Activation
proinflammatory
signaling
pathways
events
induce
low-grade
chronic
with
consequent
Identifying
mechanism-specific
targets
might
provide
opportunities
novel
therapeutic
approaches.
Monoclonal
antibodies
targeting
inflammatory
cytokines
drugs,
show
promise
reducing
associated
diseases.
this
article,
we
a
comprehensive
discussion
mechanisms
underlying
offer
insights
into
innovative
strategies
that
ameliorate
injury
Melatonin
appears
to
be
a
promising
supplement
for
obesity
treatment.
The
antiobesity
effects
of
melatonin
on
obese
rodents
are
influenced
by
various
factors,
including
the
species,
sex,
dosage
melatonin,
treatment
duration,
administration
via,
daily
time,
and
initial
body
weight
(IBW).
Therefore,
we
conducted
meta-analysis
machine
learning
study
evaluate
effect
mice
or
rats
from
31
publications.
results
showed
that
significantly
reduced
weight,
serum
glucose
(GLU),
triglycerides
(TGs),
low-density
lipoprotein
(LDL),
cholesterol
(TC)
levels
in
but
increased
high-density
(HDL)
levels.
slight
positive
clock-related
genes,
although
number
studies
was
limited.
Meta-regression
analysis
indicated
primary
factor
influencing
with
higher
dosages
leading
stronger
reduction
effect.
Together,
male
C57BL/6
Sprague-Dawley
an
IBW
100-200
g
better
when
supplemented
dose
10-30
mg/kg
administered
at
night
via
injection
5-8
weeks.
Scientific Reports,
Год журнала:
2022,
Номер
12(1)
Опубликована: Апрель 19, 2022
Abstract
Environmental
toxicants
have
been
shown
to
promote
the
epigenetic
transgenerational
inheritance
of
disease
through
exposure
specific
alterations
in
germline.
The
current
study
examines
actions
hydrocarbon
jet
fuel,
dioxin,
pesticides
(permethrin
and
methoxychlor),
plastics,
herbicides
(glyphosate
atrazine)
promotion
great
grand-offspring
rats
that
correlates
with
associated
differential
DNA
methylation
regions
(DMRs).
observed
was
similar
for
all
exposures
includes
pathologies
kidney,
prostate,
testis,
pubertal
abnormalities,
obesity.
DMRs
sperm
were
each
pathology
negligible
overlap.
Therefore,
genes
distinct
generational
lineage.
Observations
suggest
a
large
number
are
involved
pathology,
various
environmental
influence
unique
subsets
developmental
origins
susceptibility
later
life.
A
novel
multiscale
systems
biology
basis
etiology
is
proposed
involving
an
integration
epigenetics,
genetics
toxicology.
