Meta‐analysis and machine learning reveal the antiobesity effects of melatonin on obese rodents

Obesity Reviews, Journal Year: 2024, Volume and Issue: 25(5)

Published: Feb. 4, 2024

Melatonin appears to be a promising supplement for obesity treatment. The antiobesity effects of melatonin on obese rodents are influenced by various factors, including the species, sex, dosage melatonin, treatment duration, administration via, daily time, and initial body weight (IBW). Therefore, we conducted meta-analysis machine learning study evaluate effect mice or rats from 31 publications. results showed that significantly reduced weight, serum glucose (GLU), triglycerides (TGs), low-density lipoprotein (LDL), cholesterol (TC) levels in but increased high-density (HDL) levels. slight positive clock-related genes, although number studies was limited. Meta-regression analysis indicated primary factor influencing with higher dosages leading stronger reduction effect. Together, male C57BL/6 Sprague-Dawley an IBW 100-200 g better when supplemented dose 10-30 mg/kg administered at night via injection 5-8 weeks.

Language: Английский

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Obesity Management and Chronic Kidney Disease

Seminars in Nephrology, Journal Year: 2021, Volume and Issue: 41(4), P. 392 - 402

Published: July 1, 2021

Language: Английский

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Environmental induced transgenerational inheritance impacts systems epigenetics in disease etiology

Scientific Reports, Journal Year: 2022, Volume and Issue: 12(1)

Published: April 19, 2022

Abstract Environmental toxicants have been shown to promote the epigenetic transgenerational inheritance of disease through exposure specific alterations in germline. The current study examines actions hydrocarbon jet fuel, dioxin, pesticides (permethrin and methoxychlor), plastics, herbicides (glyphosate atrazine) promotion great grand-offspring rats that correlates with associated differential DNA methylation regions (DMRs). observed was similar for all exposures includes pathologies kidney, prostate, testis, pubertal abnormalities, obesity. DMRs sperm were each pathology negligible overlap. Therefore, genes distinct generational lineage. Observations suggest a large number are involved pathology, various environmental influence unique subsets developmental origins susceptibility later life. A novel multiscale systems biology basis etiology is proposed involving an integration epigenetics, genetics toxicology.

Language: Английский

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Serum Levels of IL-1 RA Increase with Obesity and Type 2 Diabetes in Relation to Adipose Tissue Dysfunction and are Reduced After Bariatric Surgery in Parallel to Adiposity

Journal of Inflammation Research, Journal Year: 2022, Volume and Issue: Volume 15, P. 1331 - 1345

Published: Feb. 1, 2022

Excess adiposity leads to a dysfunctional adipose tissue that contributes the development of obesity-associated comorbidities such as type 2 diabetes (T2D). Interleukin-1 receptor antagonist (IL-1RA) is naturally occurring IL-1 with anti-inflammatory properties. The aim present study was compare circulating concentrations IL-1RA and its mRNA expression in visceral (VAT) subjects normal weight (NW), obesity normoglycemia (OB-NG), or impaired glucose tolerance T2D (OB-IGT&T2D) analyze effect changes body fat percentage (BF%) on levels.Serum were measured 156 volunteers. Expression IL1RN VAT obtained from 36 individuals determined. In addition, before after gain well loss following dietetic program Roux-en-Y gastric bypass (RYGB).Serum levels significantly increased obesity, being further OB-IGT&T2D group (NW 440 ± 316, OB-NG 899 562, 1265 739 pg/mL; P<0.001) associated markers inflammation fatty liver. correlated global cohort SPP1, CCL2, CD68, MMP9. Levels not modified modest BF%, but RYGB-induced decreased 1233 1009 660 538 pg/mL (P<0.001).Serum are patients elevated IGT association dysfunction. markedly relation genes involved macrophage recruitment, matrix remodeling. Serum reduced when notable amount BF% loss. Measurement an excellent biomarker dysfunction metabolic alterations.

Language: Английский

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Bacteroides ovatus-mediated CD27− MAIT cell activation is associated with obesity-related T2D progression

Cellular and Molecular Immunology, Journal Year: 2022, Volume and Issue: 19(7), P. 791 - 804

Published: May 11, 2022

Language: Английский

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