ACS Nano,
Год журнала:
2023,
Номер
17(20), С. 19581 - 19599
Опубликована: Окт. 11, 2023
Transition
metal
elements,
such
as
copper,
play
diverse
and
pivotal
roles
in
oncology.
They
act
constituents
of
metalloenzymes
involved
cellular
metabolism,
function
signaling
molecules
to
regulate
the
proliferation
metastasis
tumors,
are
integral
components
metal-based
anticancer
drugs.
Notably,
recent
research
reveals
that
excessive
copper
can
also
modulate
occurrence
programmed
cell
death
(PCD),
known
cuprotosis,
cancer
cells.
This
modulation
occurs
through
disruption
tumor
metabolism
induction
proteotoxic
stress.
discovery
uncovers
a
mode
interaction
between
transition
metals
proteins,
emphasizing
intricate
link
homeostasis
metabolism.
Moreover,
they
provide
innovative
therapeutic
strategies
for
precise
diagnosis
treatment
malignant
tumors.
At
crossroads
chemistry
oncology,
we
undertake
comprehensive
review
elucidating
molecular
mechanisms
underpinning
cuproptosis.
Additionally,
summarize
current
nanotherapeutic
approaches
target
cuproptosis
an
overview
available
laboratory
clinical
methods
monitoring
this
process.
In
context
emerging
concepts,
challenges,
opportunities,
emphasize
significant
potential
nanotechnology
advancement
field.
Frontiers in Immunology,
Год журнала:
2022,
Номер
13
Опубликована: Июнь 30, 2022
Different
stimuli
can
polarize
macrophages
into
two
basic
types,
M1
and
M2.
Tumor-associated
(TAMs)
in
the
tumor
microenvironment
(TME)
are
composed
of
heterogeneous
subpopulations,
which
include
anti-tumor
M2
pro-tumor
phenotypes.
TAMs
predominantly
play
a
M2-like
tumor-promoting
role
TME
regulate
various
malignant
effects,
such
as
angiogenesis,
immune
suppression,
metastasis;
hence,
have
emerged
hot
topic
research
cancer
therapy.
This
review
focuses
on
three
main
aspects
TAMs.
First,
we
summarize
macrophage
polarization
along
with
effects
TME.
Second,
recent
advances
challenges
treatment
checkpoint
blockade
CAR-T
cell
therapy
emphasized.
Finally,
factors,
signaling
pathways,
associated
TAM
potential
strategies
for
targeting
repolarization
to
pro-inflammatory
phenotype
discussed.
Cancer Cell,
Год журнала:
2022,
Номер
40(4), С. 424 - 437.e5
Опубликована: Март 17, 2022
The
tumor
microenvironment
(TME)
is
connected
to
immunotherapy
responses,
but
it
remains
unclear
how
cancer
cells
and
host
tissues
differentially
influence
the
immune
composition
within
TME.
Here,
we
performed
single-cell
analyses
for
autologous
samples
from
liver
metastasized
colorectal
disentangle
factors
shaping
By
aligning
CD45+
across
different
tissues,
classified
exhausted
CD8+
T
(Texs)
activated
regulatory
as
M-type,
whose
phenotypes
were
associated
with
malignancy,
while
natural
killer
mucosal-associated
invariant
defined
N-type,
niche.
cell
receptor
sharing
between
Texs
in
primary
metastatic
tumors
implicated
presence
of
common
peripheral
non-exhausted
precursors.
For
myeloid
cells,
a
subset
dendritic
(DC3s)
SPP1+
macrophages
latter
predominant
metastasis,
indicating
its
pro-metastasis
role.
Our
bridge
tumors,
thereby
helping
understand
tumor-specific
contexture
identify
components.
Abstract
Recent
progress
in
immunobiology
has
led
the
way
to
successful
host
immunity
enhancement
against
breast
cancer.
In
triple-negative
cancer,
combination
of
cancer
immunotherapy
based
on
PD-1/PD-L1
immune
checkpoint
inhibitors
with
chemotherapy
was
effective
both
advanced
and
early
setting
phase
3
clinical
trials.
These
encouraging
results
lead
first
approvals
thus
offer
new
therapeutic
possibilities
aggressive
tumors
hard-to-treat
populations.
Furthermore,
several
ongoing
trials
are
investigating
combining
immunotherapies
involving
conventional
therapies
as
well
other
immunotherapeutic
strategies
such
vaccines,
CAR-T
cells,
bispecific
antibodies,
oncolytic
viruses
all
subtypes.
This
review
provides
an
overview
currently
under
development
updated
key
from
Finally,
we
discuss
challenges
implementation
treatment
managing
their
implications
for
design
future
Signal Transduction and Targeted Therapy,
Год журнала:
2023,
Номер
8(1)
Опубликована: Май 13, 2023
Abstract
In
the
past
period,
due
to
rapid
development
of
next-generation
sequencing
technology,
accumulating
evidence
has
clarified
complex
role
human
microbiota
in
cancer
and
therapeutic
response.
More
importantly,
available
seems
indicate
that
modulating
composition
gut
improve
efficacy
anti-cancer
drugs
may
be
feasible.
However,
intricate
complexities
exist,
a
deep
comprehensive
understanding
how
interacts
with
is
critical
realize
its
full
potential
treatment.
The
purpose
this
review
summarize
initial
clues
on
molecular
mechanisms
regarding
mutual
effects
between
development,
highlight
relationship
microbes
immunotherapy,
chemotherapy,
radiation
therapy
surgery,
which
provide
insights
into
formulation
individualized
strategies
for
management.
addition,
current
emerging
microbial
interventions
as
well
their
clinical
applications
are
summarized.
Although
many
challenges
remain
now,
great
importance
cannot
overstated
strategies,
it
necessary
explore
holistic
approach
incorporates
modulation
cancer.
