Cancer Cell, Год журнала: 2024, Номер 42(5), С. 747 - 758
Опубликована: Апрель 25, 2024
Язык: Английский
Nature Genetics, Год журнала: 2024, Номер 56(9), С. 1925 - 1937
Опубликована: Авг. 28, 2024
The complex and dynamic cellular composition of the human endometrium remains poorly understood. Previous endometrial single-cell atlases profiled few donors lacked consensus in defining cell types. We introduce Human Endometrial Cell Atlas (HECA), a high-resolution reference atlas (313,527 cells) combining published new transcriptomics datasets 63 women with without endometriosis. HECA assigns identifies previously unreported types, mapped situ using spatial validated independent single-nuclei dataset (312,246 nuclei, donors). In functionalis, we identify intricate stromal-epithelial coordination via transforming growth factor beta (TGFβ) signaling. basalis, define signaling between fibroblasts an epithelial population expressing progenitor markers. Integration large-scale endometriosis genome-wide association study data pinpoints decidualized stromal cells macrophages as most likely dysregulated is valuable resource for studying physiology disorders, guiding microphysiological vitro systems development.
Язык: Английский
Процитировано
38
Cancer Discovery, Год журнала: 2024, Номер 14(8), С. 1418 - 1439
Опубликована: Март 27, 2024
Abstract Tumor-associated macrophages are transcriptionally heterogeneous, but the spatial distribution and cell interactions that shape macrophage tissue roles remain poorly characterized. Here, we spatially resolve five distinct human populations in normal malignant breast colon reveal their cellular associations. This map reveals reside segregated micro-environmental niches with conserved compositions repeated across healthy diseased tissue. We show IL4I1+ phagocytose dying cells areas high turnover predict good outcome cancer. In contrast, SPP1+ enriched hypoxic necrotic tumor regions portend worse A subset of FOLR2+ is embedded plasma niches. NLRP3+ co-localize neutrophils activate an inflammasome tumors. Our findings indicate a limited number unique function as fundamental building blocks Significance: work broadens our understanding different may exert on cancer growth potential predictive markers population-specific therapy targets.
Язык: Английский
Процитировано
34
The Journal of Experimental Medicine, Год журнала: 2024, Номер 221(7)
Опубликована: Май 21, 2024
The majority of cancer patients receive radiotherapy during the course treatment, delivered with curative intent for local tumor control or as part a multimodality regimen aimed at eliminating distant metastasis. A major focus research has been DNA damage; however, in past two decades, emphasis shifted to important role immune system plays radiotherapy-induced anti-tumor effects. Radiotherapy reprograms microenvironment, triggering and RNA sensing cascades that activate innate immunity ultimately enhance adaptive immunity. In opposition, also induces suppression immunity, including recruitment regulatory T cells, myeloid-derived suppressor suppressive macrophages. balance pro- is regulated by chemokines cytokines. Microbiota can influence outcomes under clinical investigation. Blockade PD-1/PD-L1 axis CTLA-4 extensively investigated combination radiotherapy; we include review trials involving inhibition these checkpoints radiotherapy.
Язык: Английский
Процитировано
30
Molecular Cancer, Год журнала: 2024, Номер 23(1)
Опубликована: Июль 27, 2024
Abstract Tumor-associated macrophages (TAMs) are pivotal in cancer progression, influencing tumor growth, angiogenesis, and immune evasion. This review explores the spatial temporal heterogeneity of TAMs within microenvironment (TME), highlighting their diverse subtypes, origins, functions. Advanced technologies such as single-cell sequencing multi-omics have elucidated intricate interactions between other TME components, revealing mechanisms behind recruitment, polarization, distribution. Key findings demonstrate that support vascularization, promote epithelial-mesenchymal transition (EMT), modulate extracellular matrix (ECM) remodeling, etc., thereby enhancing invasiveness metastasis. Understanding these complex dynamics offers new therapeutic targets for disrupting TAM-mediated pathways overcoming drug resistance. underscores potential targeting to develop innovative therapies, emphasizing need further research into characteristics functional roles TME.
Язык: Английский
Процитировано
28
Cancer Cell, Год журнала: 2024, Номер 42(5), С. 747 - 758
Опубликована: Апрель 25, 2024
Язык: Английский
Процитировано
27