Cancer Cell, Journal Year: 2024, Volume and Issue: 42(5), P. 747 - 758
Published: April 25, 2024
Language: Английский
Cancer Discovery, Journal Year: 2024, Volume and Issue: 14(8), P. 1418 - 1439
Published: March 27, 2024
Abstract Tumor-associated macrophages are transcriptionally heterogeneous, but the spatial distribution and cell interactions that shape macrophage tissue roles remain poorly characterized. Here, we spatially resolve five distinct human populations in normal malignant breast colon reveal their cellular associations. This map reveals reside segregated micro-environmental niches with conserved compositions repeated across healthy diseased tissue. We show IL4I1+ phagocytose dying cells areas high turnover predict good outcome cancer. In contrast, SPP1+ enriched hypoxic necrotic tumor regions portend worse A subset of FOLR2+ is embedded plasma niches. NLRP3+ co-localize neutrophils activate an inflammasome tumors. Our findings indicate a limited number unique function as fundamental building blocks Significance: work broadens our understanding different may exert on cancer growth potential predictive markers population-specific therapy targets.
Language: Английский
Citations
30
The Journal of Experimental Medicine, Journal Year: 2024, Volume and Issue: 221(7)
Published: May 21, 2024
The majority of cancer patients receive radiotherapy during the course treatment, delivered with curative intent for local tumor control or as part a multimodality regimen aimed at eliminating distant metastasis. A major focus research has been DNA damage; however, in past two decades, emphasis shifted to important role immune system plays radiotherapy-induced anti-tumor effects. Radiotherapy reprograms microenvironment, triggering and RNA sensing cascades that activate innate immunity ultimately enhance adaptive immunity. In opposition, also induces suppression immunity, including recruitment regulatory T cells, myeloid-derived suppressor suppressive macrophages. balance pro- is regulated by chemokines cytokines. Microbiota can influence outcomes under clinical investigation. Blockade PD-1/PD-L1 axis CTLA-4 extensively investigated combination radiotherapy; we include review trials involving inhibition these checkpoints radiotherapy.
Language: Английский
Citations
27
Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)
Published: July 27, 2024
Abstract Tumor-associated macrophages (TAMs) are pivotal in cancer progression, influencing tumor growth, angiogenesis, and immune evasion. This review explores the spatial temporal heterogeneity of TAMs within microenvironment (TME), highlighting their diverse subtypes, origins, functions. Advanced technologies such as single-cell sequencing multi-omics have elucidated intricate interactions between other TME components, revealing mechanisms behind recruitment, polarization, distribution. Key findings demonstrate that support vascularization, promote epithelial-mesenchymal transition (EMT), modulate extracellular matrix (ECM) remodeling, etc., thereby enhancing invasiveness metastasis. Understanding these complex dynamics offers new therapeutic targets for disrupting TAM-mediated pathways overcoming drug resistance. underscores potential targeting to develop innovative therapies, emphasizing need further research into characteristics functional roles TME.
Language: Английский
Citations
26
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 14
Published: Jan. 29, 2024
Tumor-associated macrophages (TAMs) are present in almost all solid tumor tissues. 16They play critical roles immune regulation, angiogenesis, stem cell activation, invasion and metastasis, resistance to therapy. However, it is unclear how TAMs perform these functions. With the application of single-cell RNA sequencing (scRNA-seq), has become possible identify TAM subpopulations associated with distinct In this review, we discuss four novel tumors based on core gene signatures by scRNA-seq, including FCN1 + , SPP1 C1Q CCL18 TAMs. Functional enrichment expression scRNA-seq data from different tissues found that may induce inflammation; potentially involved cancer whereas participate regulation suppression; And cells terminal immunosuppressive not only have a stronger function but also enhance metastasis. can be further divided into populations Meanwhile, will emerging evidence highlighting separating macrophage there exist potential disconnects between types identified their actual function.
Language: Английский
Citations
23
Cancer Cell, Journal Year: 2024, Volume and Issue: 42(5), P. 747 - 758
Published: April 25, 2024
Language: Английский
Citations
23