Experience-dependent reorganization of inhibitory neuron synaptic connectivity DOI Creative Commons
Andrew J. P. Fink, Samuel P. Muscinelli, Shuqi Wang

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Янв. 16, 2025

Organisms continually tune their perceptual systems to the features they encounter in environment 1-3 . We have studied how ongoing experience reorganizes synaptic connectivity of neurons olfactory (piriform) cortex mouse. developed an approach measure vivo , training a deep convolutional network reliably identify monosynaptic connections from spike-time cross-correlograms 4.4 million single-unit pairs. This revealed that excitatory piriform with similar odor tuning are more likely be connected. asked whether enhances this like-to-like but found it was unaffected by exposure. Experience did, however, alter logic interneuron connectivity. Following repeated encounters set odorants, inhibitory responded differentially these stimuli exhibited high degree both incoming and outgoing within cortical network. reorganization depended only on not its pre- or postsynaptic partners. A computational model reorganized predicts increases dimensionality entire network's responses familiar stimuli, thereby enhancing discriminability. confirmed network-level property is present physiological measurements, which showed increased separability evoked versus novel odorants. Thus, simple, non-Hebbian may selectively enhance organism's discrimination environment.

Язык: Английский

Cell-type profiling in salamanders identifies innovations in vertebrate forebrain evolution DOI
Jamie Woych, Alonso Ortega Gurrola, Astrid Deryckere

и другие.

Science, Год журнала: 2022, Номер 377(6610)

Опубликована: Сен. 1, 2022

The evolution of advanced cognition in vertebrates is associated with two independent innovations the forebrain: six-layered neocortex mammals and dorsal ventricular ridge (DVR) sauropsids (reptiles birds). How these arose vertebrate ancestors remains unclear. To reconstruct forebrain tetrapods, we built a cell-type atlas telencephalon salamander Pleurodeles waltl . Our molecular, developmental, connectivity data indicate that parts sauropsid DVR trace back to tetrapod ancestors. By contrast, pallium devoid cellular molecular characteristics mammalian yet shares similarities entorhinal cortex subiculum. findings chart series resulted emergence DVR.

Язык: Английский

Процитировано

80
Whole-cortex in situ sequencing reveals input-dependent area identity DOI Creative Commons
Xiaoyin Chen, Stephan Fischer,

M. Rué

и другие.

Nature, Год журнала: 2024, Номер unknown

Опубликована: Апрель 24, 2024

The cerebral cortex is composed of neuronal types with diverse gene expression that are organized into specialized cortical areas. These areas, each characteristic cytoarchitecture1,2, connectivity3,4 and activity5,6, wired modular networks3,4,7. However, it remains unclear whether these spatial organizations reflected in transcriptomic signatures how such established development. Here we used BARseq, a high-throughput situ sequencing technique, to interrogate the 104 cell-type marker genes 10.3 million cells, including 4,194,658 neurons over nine mouse forebrain hemispheres, at cellular resolution. De novo clustering single revealed consistent previous single-cell RNA studies8,9. composition highly predictive area identity. Moreover, areas similar compositions types, which defined as modules, overlap connected, suggesting same organization both connectivity. To explore profiles depend on development, assessed distributions after neonatal binocular enucleation. Notably, enucleation caused shifting compositional visual towards neighbouring within module, peripheral inputs sharpen distinct identities modules. Enabled by high throughput, low cost reproducibility our study provides proof principle for use large-scale reveal brain-wide molecular architecture understand its

Язык: Английский

Процитировано

24
Common principles for odour coding across vertebrates and invertebrates DOI

Kara A Fulton,

David Zimmerman,

Aravi Samuel

и другие.

Nature reviews. Neuroscience, Год журнала: 2024, Номер 25(7), С. 453 - 472

Опубликована: Май 28, 2024

Язык: Английский

Процитировано

22
A molecularly defined amygdala-independent tetra-synaptic forebrain-to-hindbrain pathway for odor-driven innate fear and anxiety DOI
Hao Wang, Qin Wang,

Liuzhe Cui

и другие.

Nature Neuroscience, Год журнала: 2024, Номер 27(3), С. 514 - 526

Опубликована: Фев. 12, 2024

Язык: Английский

Процитировано

19
Olfactory deficit: a potential functional marker across the Alzheimer’s disease continuum DOI Creative Commons
Dongming Liu, Jiaming Lu, Liangpeng Wei

и другие.

Frontiers in Neuroscience, Год журнала: 2024, Номер 18

Опубликована: Фев. 16, 2024

Alzheimer's disease (AD) is a prevalent form of dementia that affects an estimated 32 million individuals globally. Identifying early indicators vital for screening at-risk populations and implementing timely interventions. At present, there urgent need sensitive biomarkers to screen at risk AD. Among all sensory biomarkers, olfaction currently one the most promising Olfactory dysfunction signifies decline in ability detect, identify, or remember odors. Within spectrum AD, impairment olfactory identification precedes detectable cognitive impairments, including mild (MCI) even stage subjective (SCD), by several years. closely linked clinical symptoms neuropathological accompanied significant structural functional abnormalities brain. behavior examination can subjectively evaluate abilities identification, threshold, discrimination. magnetic resonance imaging (fMRI) provide relatively objective assessment capabilities, with potential become tool exploring neural mechanisms damage Here, we review recent literature on characteristics, neuropathology, AD continuum. We focus changes detected behavioral fMRI assessments discuss these techniques MCI preclinical Despite challenges limitations existing research, has demonstrated its value assessing neurodegenerative diseases may serve as indicator future.

Язык: Английский

Процитировано

16
Sexually dimorphic control of affective state processing and empathic behaviors DOI Creative Commons
Shunchang Fang,

Zheng-Yi Luo,

Zicheng Wei

и другие.

Neuron, Год журнала: 2024, Номер 112(9), С. 1498 - 1517.e8

Опубликована: Март 1, 2024

Recognizing the affective states of social counterparts and responding appropriately fosters successful interactions. However, little is known about how are expressed perceived they influence decisions. Here, we show that male female mice emit distinct olfactory cues after experiencing distress. These activate neural circuits in piriform cortex (PiC) evoke sexually dimorphic empathic behaviors observers. Specifically, PiC → PrL pathway activated observers, inducing a preference for distressed counterpart. Conversely, MeA evoking excessive self-grooming behaviors. pathways originate from non-overlapping neuron populations with gene expression signatures regulated by transcription factors sex hormones. Our study unveils internal processed through mechanisms at molecular, cellular, circuit levels offers insights into underpinning differences higher brain functions.

Язык: Английский

Процитировано

16
Advances in Spatial Omics Technologies DOI
Tianqian Hui, Jian Zhou,

Ming Yao

и другие.

Small Methods, Год журнала: 2025, Номер unknown

Опубликована: Март 18, 2025

Abstract Rapidly developing spatial omics technologies provide us with new approaches to deeply understanding the diversity and functions of cell types within organisms. Unlike traditional approaches, enable researchers dissect complex relationships between tissue structure function at cellular or even subcellular level. The application provides perspectives on key biological processes such as nervous system development, organ tumor microenvironment. This review focuses advancements strategies technologies, summarizes their applications in biomedical research, highlights power advancing life sciences related development disease.

Язык: Английский

Процитировано

1
Olfactory bulb activity shapes the development of entorhinal-hippocampal coupling and associated cognitive abilities DOI Creative Commons
Yunan Chen, Johanna K. Kostka, Sebastian H. Bitzenhofer

и другие.

Current Biology, Год журнала: 2023, Номер 33(20), С. 4353 - 4366.e5

Опубликована: Сен. 19, 2023

The interplay between olfaction and higher cognitive processing has been documented in the adult brain; however, its development is poorly understood. In mice, shortly after birth, endogenous stimulus-evoked activity olfactory bulb (OB) boosts oscillatory entrainment of downstream lateral entorhinal cortex (LEC) hippocampus (HP). However, it unclear whether early OB a long-lasting impact on entorhinal-hippocampal function processing. Here, we chemogenetically silenced synaptic outputs mitral/tufted cells, main projection neurons OB, during postnatal days 8-10. transient manipulation leads to reduction coupling weaker responsiveness stimuli within developing circuits accompanied by dendritic sparsification LEC pyramidal neurons. Moreover, silencing reduces performance behavioral tests involving later life. Thus, neonatal critical for functional LEC-HP maturation abilities.

Язык: Английский

Процитировано

19
Potential convergence of olfactory dysfunction in Parkinson’s disease and COVID-19: The role of neuroinflammation DOI
Hui Li, Junliang Qian, Youcui Wang

и другие.

Ageing Research Reviews, Год журнала: 2024, Номер 97, С. 102288 - 102288

Опубликована: Апрель 4, 2024

Язык: Английский

Процитировано

9
Probing neural circuit mechanisms in Alzheimer’s disease using novel technologies DOI Creative Commons
Steven F. Grieco, Todd C. Holmes, Xiangmin Xu

и другие.

Molecular Psychiatry, Год журнала: 2023, Номер 28(10), С. 4407 - 4420

Опубликована: Март 23, 2023

The study of Alzheimer's Disease (AD) has traditionally focused on neuropathological mechanisms that guided therapies attenuate features. A new direction is emerging in AD research focuses the progressive loss cognitive function due to disrupted neural circuit mechanisms. Evidence from humans and animal models show dysregulated circuits initiate a cascade pathological events culminate functional learning, memory, other aspects cognition. Recent progress single-cell, spatial, omics informs this circuit-focused approach by determining identities, locations, circuitry specific cells affected AD. Recently developed neuroscience tools allow for precise access cell type-specific so their roles AD-related deficits disease progression can be tested. An integrated systems-level understanding AD-associated requires multimodal multi-scale interrogations longitudinally measure and/or manipulate ensemble properties molecularly-defined neuron populations first susceptible These newly technological conceptual advances present opportunities studying treating vulnerable represent beginning era circuit-based research.

Язык: Английский

Процитировано

17