Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Янв. 3, 2024
Abstract
Recently,
multi-drug
resistant
(MDR)
bacteria
are
responsible
for
a
large
number
of
infectious
diseases
that
can
be
life-threatening.
Globally,
new
approaches
targeted
to
solve
this
essential
issue.
This
study
aims
discover
novel
antibiotic
alternatives
by
using
the
whole
components
biofilm
layer
as
macromolecule
synthesize
silver
nanoparticles
(AgNPs)
promising
agent
against
MDR.
In
particular,
biosynthesized
biofilm-AgNPs
were
characterized
UV-Vis
spectroscopy,
electron
microscopes,
Energy
Dispersive
X-ray
(EDX),
zeta
sizer
and
potential
while
their
effect
on
bacterial
strains
normal
cell
lines
was
identified.
Accordingly,
have
lavender-colored
solution,
spherical
shape,
with
size
range
20–60
nm.
Notably,
they
inhibitory
effects
when
used
various
concentrations
ranging
between
12.5
25
µg/mL.
addition,
an
effective
synergistic
combined
phage
ZCSE9
inhibit
kill
Salmonella
enterica
concentration
3.1
conclusion,
work
presents
biosynthesis
preparation
AgNPs
antibacterial
purposes
reduce
possible
toxicity
reducing
MICs
ZCSE9.
Viruses,
Год журнала:
2023,
Номер
15(4), С. 1020 - 1020
Опубликована: Апрель 21, 2023
In
response
to
the
global
spread
of
antimicrobial
resistance,
there
is
an
increased
demand
for
novel
and
innovative
antimicrobials.
Bacteriophages
have
been
known
their
potential
clinical
utility
in
lysing
bacteria
almost
a
century.
Social
pressures
concomitant
introduction
antibiotics
mid-1900s
hindered
widespread
adoption
these
naturally
occurring
bactericides.
Recently,
however,
phage
therapy
has
re-emerged
as
promising
strategy
combatting
resistance.
A
unique
mechanism
action
cost-effective
production
promotes
phages
ideal
solution
addressing
antibiotic-resistant
bacterial
infections,
particularly
lower-
middle-income
countries.
As
number
phage-related
research
labs
worldwide
continues
grow,
it
will
be
increasingly
important
encourage
expansion
well-developed
trials,
standardization
storage
cocktails,
advancement
international
collaboration.
this
review,
we
discuss
history,
benefits,
limitations
bacteriophage
its
current
role
setting
resistance
with
specific
focus
on
active
trials
case
reports
administration.
Signal Transduction and Targeted Therapy,
Год журнала:
2023,
Номер
8(1)
Опубликована: Дек. 6, 2023
Gut-liver-brain
axis
is
a
three-way
highway
of
information
interaction
system
among
the
gastrointestinal
tract,
liver,
and
nervous
systems.
In
past
few
decades,
breakthrough
progress
has
been
made
in
gut
liver
brain
axis,
mainly
through
understanding
its
formation
mechanism
increasing
treatment
strategies.
this
review,
we
discuss
various
complex
networks
including
barrier
permeability,
hormones,
microbial
metabolites,
vagus
nerve,
neurotransmitters,
immunity,
toxic
β-amyloid
(Aβ)
metabolism,
epigenetic
regulation
gut-liver-brain
axis.
Some
therapies
containing
antibiotics,
probiotics,
prebiotics,
synbiotics,
fecal
microbiota
transplantation
(FMT),
polyphenols,
low
FODMAP
diet
nanotechnology
application
regulate
Besides,
some
special
treatments
targeting
gut-liver
include
farnesoid
X
receptor
(FXR)
agonists,
takeda
G
protein-coupled
5
(TGR5)
glucagon-like
peptide-1
(GLP-1)
antagonists
fibroblast
growth
factor
19
(FGF19)
analogs.
Targeting
gut-brain
embraces
cognitive
behavioral
therapy
(CBT),
antidepressants
tryptophan
metabolism-related
therapies.
liver-brain
contains
Aβ
future,
better
interactions
will
promote
development
novel
preventative
strategies
discovery
precise
therapeutic
targets
multiple
diseases.
PLoS Biology,
Год журнала:
2023,
Номер
21(5), С. e3002119 - e3002119
Опубликована: Май 23, 2023
Phage
therapy
is
a
medical
form
of
biological
control
bacterial
infections,
one
that
uses
naturally
occurring
viruses,
called
bacteriophages
or
phages,
as
antibacterial
agents.
Pioneered
over
100
years
ago,
phage
nonetheless
currently
experiencing
resurgence
in
interest,
with
growing
numbers
clinical
case
studies
being
published.
This
renewed
enthusiasm
due
large
part
to
holding
promise
for
providing
safe
and
effective
cures
infections
traditional
antibiotics
acting
alone
have
been
unable
clear.
Essay
introduces
basic
biology,
provides
an
outline
the
long
history
therapy,
highlights
some
advantages
using
phages
agents,
overview
recent
successes.
Although
has
clear
potential,
it
faces
biological,
regulatory,
economic
challenges
its
further
implementation
more
mainstream
acceptance.
Pharmaceuticals,
Год журнала:
2023,
Номер
16(12), С. 1638 - 1638
Опубликована: Ноя. 22, 2023
The
increasing
drug
resistance
of
bacteria
to
commonly
used
antibiotics
creates
the
need
search
for
and
develop
alternative
forms
treatment.
Phage
therapy
fits
this
trend
perfectly.
Phages
that
selectively
infect
kill
are
often
only
life-saving
therapeutic
option.
Full
legalization
treatment
method
could
help
solve
problem
multidrug-resistant
infectious
diseases
on
a
global
scale.
aim
review
is
present
prospects
development
phage
therapy,
ethical
legal
aspects
form
given
current
situation
such
benefits
using
products
in
persons
whom
available
options
have
been
exhausted
or
do
not
exist
at
all.
In
addition,
challenges
faced
by
fight
against
bacterial
infections
also
described.
More
clinical
studies
needed
expand
knowledge
about
phages,
their
dosage,
standardized
delivery
system.
These
activities
necessary
ensure
phage-based
does
take
an
experiment
but
standard
medical
Bacterial
viruses
will
probably
become
miracle
cure—a
panacea
infections—but
they
chance
find
important
place
medicine.
Signal Transduction and Targeted Therapy,
Год журнала:
2024,
Номер
9(1)
Опубликована: Июль 17, 2024
Abstract
Persisters
refer
to
genetically
drug
susceptible
quiescent
(non-growing
or
slow
growing)
bacteria
that
survive
in
stress
environments
such
as
antibiotic
exposure,
acidic
and
starvation
conditions.
These
cells
can
regrow
after
removal
remain
the
same
stress.
are
underlying
problems
of
treating
chronic
persistent
infections
relapse
treatment,
resistance
development,
biofilm
infections,
pose
significant
challenges
for
effective
treatments.
Understanding
characteristics
exact
mechanisms
persister
formation,
especially
key
molecules
affect
formation
survival
persisters
is
critical
more
treatment
infections.
Currently,
genes
related
being
discovered
confirmed,
but
by
which
form
very
complex,
there
still
many
unanswered
questions.
This
article
comprehensively
summarizes
historical
background
bacterial
persisters,
details
their
complex
relationship
with
tolerant
resistant
bacteria,
systematically
elucidates
interplay
between
various
biological
processes
cells,
well
consolidates
diverse
anti-persister
compounds
We
hope
provide
theoretical
in-depth
research
on
suggest
new
ideas
choosing
strategies
npj Science of Food,
Год журнала:
2024,
Номер
8(1)
Опубликована: Янв. 3, 2024
Abstract
Bacteriophages
infect
and
replicate
inside
a
bacterial
host
as
well
serve
natural
bio-control
agents.
Phages
were
once
viewed
nuisances
that
caused
fermentation
failures
with
cheese-making
other
industrial
processes,
which
lead
to
economic
losses,
but
phages
are
now
increasingly
being
observed
promising
antimicrobials
can
fight
against
spoilage
pathogenic
bacteria.
Pathogen-free
meals
fulfil
industry
requirements
without
synthetic
additives
always
in
demand
the
food
sector.
This
study
introduces
readers
history,
sources,
biology
of
bacteriophages,
include
their
ranges,
absorption
mechanisms,
lytic
profiles,
lysogenic
influence
external
factors
on
growth
phages.
derivatives
have
emerged
antimicrobial
agents,
biodetectors,
biofilm
controllers,
been
comprehensively
discussed
addition
potential
applications
gastrointestinal
tract,
they
feasible
safe
option
for
preventing,
treating,
and/or
eradicating
contaminants
various
foods
processing
environments.
Furthermore,
phage-derived
proteins
be
considered
traditional
farm-to-fork
context,
phage-based
mixtures
commercially
available
phage
products.
paper
concludes
some
safety
concerns
need
addressed
enable
bacteriophage
use
efficiently.
Military Medical Research,
Год журнала:
2024,
Номер
11(1)
Опубликована: Янв. 23, 2024
Abstract
Antimicrobial
resistance
is
a
global
public
health
threat,
and
the
World
Health
Organization
(WHO)
has
announced
priority
list
of
most
threatening
pathogens
against
which
novel
antibiotics
need
to
be
developed.
The
discovery
introduction
are
time-consuming
expensive.
According
WHO’s
report
antibacterial
agents
in
clinical
development,
only
18
have
been
approved
since
2014.
Therefore,
critically
needed.
Artificial
intelligence
(AI)
rapidly
applied
drug
development
its
recent
technical
breakthrough
dramatically
improved
efficiency
antibiotics.
Here,
we
first
summarized
recently
marketed
antibiotics,
antibiotic
candidates
development.
In
addition,
systematically
reviewed
involvement
AI
utilization,
including
small
molecules,
antimicrobial
peptides,
phage
therapy,
essential
oils,
as
well
mechanism
prediction,
stewardship.
