Microbial Influences on Amyotrophic Lateral Sclerosis: The Gut–Brain Axis and Therapeutic Potential of Microbiota Modulation DOI Open Access
Victòria Ayala,

Laia Fontdevila,

Santiago Rico-Rios

и другие.

Sclerosis, Год журнала: 2025, Номер 3(1), С. 8 - 8

Опубликована: Март 5, 2025

Background/Objectives: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by the progressive degeneration of motor neurons. The gut microbiota, community microorganisms in digestive tract, has recently been implicated ALS pathogenesis through its influence on neuroinflammation and metabolic pathways. This review explores potential role microbiota metabolites progression investigates therapeutic approaches targeting microbiota. Methods: A comprehensive current literature was conducted to assess relationship between composition, microbial metabolites, patients. We searched for published reports ALS, emphasizing complex interplay dysbiosis, neuroinflammation, systemic metabolism. Special emphasis placed studies exploring short-chain fatty acids (SCFAs), bacterial amyloids (curli-like factors), neurotoxins such as β-methylamino-L-alanine (BMAA). liver–gut axis evaluated well. changes would sustain rationale strategies probiotics, prebiotics, fecal transplantation (FMT), dietary interventions. Results: patients exhibit reduced SCFA-producing bacteria an increase potentially pathogenic genera. Of note, different do not agree common patterns being linked supporting need further, more extensive studies. Dysbiosis sometimes correlates with inflammation disrupted liver function, amplifying neuroinflammatory responses. Key including SCFAs, amyloids, BMAA, may exacerbate neuron promoting protein misfolding, oxidative stress, neuroinflammation. Emerging strategies, probiotics FMT, show restoring balance, although clinical data remain limited. Conclusions: could modulate metabolism ALS. Microbiota-targeted therapies, interventions, represent promising avenues mitigating disease progression. Further research required validate these interventions large-scale, longitudinal develop personalized microbiota-based treatments tailored individual phenotypes.

Язык: Английский

Bile acid metabolism and signaling in health and disease: molecular mechanisms and therapeutic targets DOI Creative Commons
Joshua S. Fleishman, Sunil Kumar

Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)

Опубликована: Апрель 25, 2024

Bile acids, once considered mere dietary surfactants, now emerge as critical modulators of macronutrient (lipid, carbohydrate, protein) metabolism and the systemic pro-inflammatory/anti-inflammatory balance. acid signaling pathways play a crucial role in protecting against, or if aberrant, inducing cardiometabolic, inflammatory, neoplastic conditions, strongly influencing health disease. No curative treatment exists for any bile influenced disease, while most promising well-developed therapeutic was recently rejected by FDA. Here, we provide bottom-up approach on mechanistically explaining their biochemistry, physiology, pharmacology at canonical non-canonical receptors. Using this mechanistic model explain how abnormal physiology drives disease pathogenesis, emphasizing ceramide synthesis may serve unifying pathogenic feature cardiometabolic diseases. We an in-depth summary pre-existing receptor modulators, shortcomings, propose solutions they be remedied. Lastly, rationalize novel targets further translational drug discovery future perspectives. Rather than dismissing therapeutics due to recent setbacks, believe that there is immense clinical potential high likelihood success therapeutics.

Язык: Английский

Процитировано

70
The intricate brain–body interaction in psychiatric and neurological diseases DOI Creative Commons
Francesco Di Gregorio, Simone Battaglia

Advances in Clinical and Experimental Medicine, Год журнала: 2024, Номер 33(4), С. 321 - 326

Опубликована: Март 21, 2024

A harmonic brain-body communication is fundamental to individual wellbeing and the basis of human cognition behavior.In last 2 decades, interaction between brain body functioning has become a central area study for neurologists neuroscientists in clinical non-clinical contexts.Indeed, axis dysfunctions occur many psychiatric, neurological neurodegenerative diseases.This editorial will focus on recent advances future therapeutic perspectives studying interactions health diseases.

Язык: Английский

Процитировано

22
Energy metabolism in health and diseases DOI Creative Commons
Hui Liu, Shuo Wang, Jianhua Wang

и другие.

Signal Transduction and Targeted Therapy, Год журнала: 2025, Номер 10(1)

Опубликована: Фев. 18, 2025

Язык: Английский

Процитировано

7
Gut microbiota in Alzheimer’s disease: Understanding molecular pathways and potential therapeutic perspectives DOI

Simone Lista,

Antonio Munafò, Filippo Caraci

и другие.

Ageing Research Reviews, Год журнала: 2025, Номер 104, С. 102659 - 102659

Опубликована: Янв. 10, 2025

Язык: Английский

Процитировано

2
Therapeutic targeting of obesity-induced neuroinflammation and neurodegeneration DOI Creative Commons
Jialiu Zeng,

Lenny Yi Tong Cheong,

Chih Hung Lo

и другие.

Frontiers in Endocrinology, Год журнала: 2025, Номер 15

Опубликована: Янв. 17, 2025

Obesity is a major modifiable risk factor leading to neuroinflammation and neurodegeneration. Excessive fat storage in obesity promotes the progressive infiltration of immune cells into adipose tissue, resulting release pro-inflammatory factors such as cytokines adipokines. These inflammatory mediators circulate through bloodstream, propagating inflammation both periphery central nervous system. Gut dysbiosis, which results leaky intestinal barrier, exacerbates plays significant role linking pathogenesis neurodegeneration gut-brain/gut-brain-liver axis. Inflammatory states within brain can lead insulin resistance, mitochondrial dysfunction, autolysosomal increased oxidative stress. disruptions impair normal neuronal function subsequently cognitive decline motor deficits, similar pathologies observed neurodegenerative diseases, including Alzheimer's disease, multiple sclerosis, Parkinson's disease. Understanding underlying disease mechanisms crucial for developing therapeutic strategies address defects these metabolic pathways. In this review, we summarize provide insights different strategies, methods alter gut lifestyle changes, dietary supplementation, well pharmacological agents derived from natural sources, that target obesity-induced

Язык: Английский

Процитировано

2
From Liver to Brain: How MAFLD/MASLD Impacts Cognitive Function DOI Open Access
David Medina‐Julio, Mariana M. Ramírez-Mejía, Jacqueline Córdova‐Gallardo

и другие.

Medical Science Monitor, Год журнала: 2024, Номер 30

Опубликована: Янв. 16, 2024

Metabolic dysfunction-associated fatty liver disease or metabolic steatotic (MAFLD/MASLD), is a common chronic condition affecting substantial global population. Beyond its primary impact on function, MAFLD/MASLD associated with myriad of extrahepatic manifestations, including cognitive impairment. The scope impairment within the realm matter escalating concern. Positioned as an intermediate stage between normal aging process and onset dementia, manifests challenge this condition. Insights from studies underscore presence compromised executive function decline in capabilities among individuals identified being at risk progressing to fibrosis. Importantly, transcends mere association factors, delving deep into intricate pathophysiology characterizing MAFLD/MASLD. multifaceted nature context underlined by spectrum prominently featuring insulin resistance, lipotoxicity, systemic inflammation pivotal contributors. These factors interplay landscape MAFLD/MASLD, fostering nuanced understanding links hepatic health function. By synthesizing available evidence, exploring potential mechanisms, assessing clinical implications, overarching aim review contribute more complete

Язык: Английский

Процитировано

14
Taming neuroinflammation in Alzheimer's disease: The protective role of phytochemicals through the gut−brain axis DOI Open Access

Yoonsu Kim,

Jinkyu Lim, Jisun Oh

и другие.

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 178, С. 117277 - 117277

Опубликована: Авг. 9, 2024

Язык: Английский

Процитировано

13
Underlying Mechanisms behind the Brain–Gut–Liver Axis and Metabolic-Associated Fatty Liver Disease (MAFLD): An Update DOI Open Access

Júlia Pauli De Cól,

Enzo Pereira de Lima,

Fernanda Moris Pompeu

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(7), С. 3694 - 3694

Опубликована: Март 26, 2024

Metabolic-associated fatty liver disease (MAFLD) includes several metabolic dysfunctions caused by dysregulation in the brain–gut–liver axis and, consequently, increases cardiovascular risks and dysfunction. In MAFLD, type 2 diabetes mellitus, obesity, syndrome are frequently present; these conditions related to lipogenesis systemic inflammation. This study aimed review connection between MAFLD. The inflammatory process, cellular alterations hepatocytes stellate cells, hypercaloric diet, sedentarism aggravate prognosis of patients with Thus, understand modulation physiopathology it is necessary include organokines involved this process (adipokines, myokines, osteokines, hepatokines) their clinical relevance project future perspectives condition bring light new possibilities therapeutic approaches. Adipokines responsible for activation distinct signaling different tissues, such as insulin pro-inflammatory cytokines, which important balancing substances avoid MAFLD its progression. Myokines improve quantity quality adipose contributing avoiding development Finally, hepatokines decisive improving or not progression through regulation anti-inflammatory organokines.

Язык: Английский

Процитировано

12
Gut microbiome and metabolome signatures in liver cirrhosis-related complications DOI Creative Commons
Satya Priya Sharma, Haripriya Gupta,

Goo-Hyun Kwon

и другие.

Clinical and Molecular Hepatology, Год журнала: 2024, Номер 30(4), С. 845 - 862

Опубликована: Июль 25, 2024

Background/Aims: Shifts in the gut microbiota and metabolites are interrelated with liver cirrhosis progression complications. However, causal relationships have not been evaluated comprehensively. Here, we identified complication-dependent metabolic signatures patients cirrhosis.Methods: Microbiome taxonomic profiling was performed on 194 stool samples (52 controls 142 patients) via V3-V4 16S rRNA sequencing. Next, 51 (17 34 were selected for fecal metabolite gas chromatography mass spectrometry liquid coupled to time-of-flight spectrometry. Correlation analyses targeting gut-microbiota, metabolites, clinical parameters, presence of complications (varices, ascites, peritonitis, encephalopathy, hepatorenal syndrome, hepatocellular carcinoma, deceased).Results: <i>Veillonella</i> bacteria, <i>Ruminococcus gnavus</i>, <i>Streptococcus pneumoniae</i> cirrhosis-related microbiotas compared control group. <i>Bacteroides ovatus, Clostridium symbiosum, Emergencia timonensis, Fusobacterium varium</i>, <i>Hungatella</i>_uc associated The areas under receiver operating characteristic curve (AUROCs) diagnosis cirrhosis, deceased 0.863, 0.733, 0.71, 0.69, respectively. AUROCs mixed microbial species complication 0.808 0.847, According profile, 5 increased biomarkers (AUROC >0.880) Clinical markers significantly correlated metabolites.Conclusions: Cirrhosis-dependent present unique that can be used as noninvasive its

Язык: Английский

Процитировано

9
Biomarkers for Health Functional Foods in Metabolic Dysfunction-Associated Steatotic Liver Disorder (MASLD) Prevention: An Integrative Analysis of Network Pharmacology, Gut Microbiota, and Multi-Omics DOI Open Access

Heng Yuan,

Eun-Soo Jung,

Soo-Wan Chae

и другие.

Nutrients, Год журнала: 2024, Номер 16(18), С. 3061 - 3061

Опубликована: Сен. 11, 2024

Metabolic dysfunction-associated steatotic liver disorder (MASLD) is increasingly prevalent globally, highlighting the need for preventive strategies and early interventions. This comprehensive review explores potential of health functional foods (HFFs) to maintain healthy function prevent MASLD through an integrative analysis network pharmacology, gut microbiota, multi-omics approaches. We first examined biomarkers associated with MASLD, emphasizing complex interplay genetic, environmental, lifestyle factors. then applied pharmacology identify food components beneficial effects on metabolic function, elucidating their action mechanisms. identifies evaluates halting or reversing development disease in stages, as well that can evaluate success failure such strategies. The crucial role microbiota its metabolites prevention homeostasis discussed. also cover state-of-the-art omics approaches, including transcriptomics, metabolomics, integrated analyses, research preventing MASLD. These advanced technologies provide deeper insights into physiological mechanisms HFF development. concludes by proposing approach developing HFFs targeting prevention, considering Korean regulatory framework. outline future directions bridge gap between basic science practical applications narrative provides a foundation researchers industry professionals interested support health. Emphasis placed maintaining balance focusing early-stage intervention

Язык: Английский

Процитировано

9