Photoperiod influences visceral adiposity and the adipose molecular clock independent of temperature in wild‐derived Peromyscus leucopus DOI Creative Commons

Margaret E. Newport,

Paul J. Wilson, Shanna Lowes

и другие.

FASEB BioAdvances, Год журнала: 2025, Номер 7(5)

Опубликована: Апрель 17, 2025

Abstract Physiology is closely synchronized to daily and seasonal light/dark cycles. Humans artificially extend daylight experience irregular light schedules, resulting in dysregulation of metabolism body mass. In rodents, winter‐like conditions (cold short photoperiod) can alter energy balance adipose tissue To determine if photoperiod alone, independent temperature, a strong enough signal regulate adiposity, we compared the effects long at thermoneutrality on adiposity WAT gene expression photoperiod‐sensitive, F1 generation wild‐derived adult male white‐footed mice ( Peromyscus leucopus ). Mice were housed long‐day (16:8 light:dark) or short‐day (8:16 (27°C) for 4 weeks with extended being provided through artificial lighting. Photoperiod did not impact weight calorie consumption. However, selectively developed greater visceral mass without changing subcutaneous interscapular BAT This was accompanied by decrease Adrβ3 Ucp1 mRNA no change Pgc1a , Lpl Hsl . Expression Per1 Per2 Nr1d1 differed between photoperiods over time when aligned circadian but onset darkness, indicating alterations clock photoperiod. These findings suggest that promote fat accumulation supporting may play role obesity.

Язык: Английский

An update on the secretory functions of brown, white, and beige adipose tissue: Towards therapeutic applications DOI Creative Commons
Zeinab Ghesmati, Mohsen Rashid, Shabnam Fayezi

и другие.

Reviews in Endocrine and Metabolic Disorders, Год журнала: 2023, Номер 25(2), С. 279 - 308

Опубликована: Дек. 5, 2023

Abstract Adipose tissue, including white adipose tissue (WAT), brown (BAT), and beige is vital in modulating whole-body energy metabolism. While WAT primarily stores energy, BAT dissipates as heat for thermoregulation. Beige a hybrid form of that shares characteristics with BAT. Dysregulation metabolism linked to various disorders, obesity, type 2 diabetes, cardiovascular diseases, cancer, infertility. Both adipocytes secrete multiple molecules, such batokines, packaged extracellular vesicles or soluble signaling molecules play autocrine, paracrine, endocrine roles. A greater understanding the adipocyte secretome essential identifying novel molecular targets treating metabolic disorders. Additionally, microRNAs show crucial roles regulating differentiation function, highlighting their potential biomarkers The browning has emerged promising therapeutic approach obesity associated Many agents have been identified, nanotechnology-based drug delivery systems developed enhance efficacy. This review scrutinizes differences between white, brown, tissues, mechanisms involved development adipocytes, significant regulatory active different tissues. Finally, atherosclerosis, relationship cancer fertility crosstalk circadian system disorders are also investigated.

Язык: Английский

Процитировано

45
Raptin, a sleep-induced hypothalamic hormone, suppresses appetite and obesity DOI Creative Commons

Ling‐Qi Xie,

Biao Hu,

Ren-Bin Lu

и другие.

Cell Research, Год журнала: 2025, Номер unknown

Опубликована: Янв. 29, 2025

Abstract Sleep deficiency is associated with obesity, but the mechanisms underlying this connection remain unclear. Here, we identify a sleep-inducible hypothalamic protein hormone in humans and mice that suppresses obesity. This cleaved from reticulocalbin-2 (RCN2), name it Raptin. Raptin release timed by circuit vasopressin-expressing neurons suprachiasmatic nucleus to RCN2-positive paraventricular nucleus. levels peak during sleep, which blunted sleep deficiency. binds glutamate metabotropic receptor 3 (GRM3) of hypothalamus stomach inhibit appetite gastric emptying, respectively. Raptin-GRM3 signaling mediates anorexigenic effects via PI3K-AKT signaling. Of note, verify connections between deficiencies sleeping state, impaired release, obesity patients Moreover, carrying an RCN2 nonsense variant present night eating syndrome These data define unique food intake prevents

Язык: Английский

Процитировано

3
Physiological rhythms and metabolic regulation: Shining light on skeletal muscle DOI Creative Commons
James A. Betts, Kelly A. Bowden Davies, Harry Smith

и другие.

Experimental Physiology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 29, 2025

Abstract Metabolic regulation is essential for maintaining homeostasis in response to fluctuating dietary nutrient availability. In this review, we explore how metabolic health can be affected by the temporal alignment between daily behavioural patterns (e.g., eating, physical activity and sleep) recurring cycles underlying physiology ‘circadian’ rhythms). Misalignment within and/or these lead dysregulation, increasing risk of chronic disease states such as obesity, type 2 diabetes cardiovascular disease. Conversely, improved strategically aligning certain with endogenous rhythms physiology. Dietary interventions based upon reasoning are referred chrono‐nutrition strategies. Skeletal muscle an important tissue relation both whole‐body metabolism behaviour plays a central role physiological respond timing delivery/availability. Few studies have examined human skeletal muscle, providing opportunities advance current understanding affects metabolism.

Язык: Английский

Процитировано

3
Advanced near‐infrared light approaches for neuroimaging and neuromodulation DOI Creative Commons

Hongqiang Yin,

Wuqiao Jiang,

Yongyang Liu

и другие.

BMEMat, Год журнала: 2023, Номер 1(2)

Опубликована: Май 5, 2023

Abstract Almost all physiological processes of animals are controlled by the brain, including language, cognitive, memory, learning, emotion and so forth. Minor brain dysfunction usually leads to diseases disorders. Therefore, it' is greatly meaningful urgent for scientists have a better understanding structure function. Optical approaches can provide powerful tools imaging modulating brain. In particular, optical in near‐infrared (NIR) window (700–1700 nm) exhibit excellent prosperities deep tissue penetration low scattering absorption compared with those visible windows (400–700 nm), which provides promising approach develop desired methods neuroimaging neuromodulation tissues. this review, variable types NIR light neural ions, membrane potential, neurotransmitters, other critical molecules functions summarized. latest breakthrough research regulation NIR‐II (1000–1700 highlighted. Finally, we conclude challenges prospects light‐based both basic further clinical translation.

Язык: Английский

Процитировано

35
Circadian-independent light regulation of mammalian metabolism DOI
Feng Rao, Tian Xue

Nature Metabolism, Год журнала: 2024, Номер 6(6), С. 1000 - 1007

Опубликована: Июнь 3, 2024

Язык: Английский

Процитировано

17
Heat stress-induced dysbiosis of the gut microbiota impairs spermatogenesis by regulating secondary bile acid metabolism in the gut DOI Creative Commons

Guitian He,

Boqi Zhang,

Kangle Yi

и другие.

The Science of The Total Environment, Год журнала: 2024, Номер 937, С. 173305 - 173305

Опубликована: Май 20, 2024

Heat stress (HS) poses a substantial challenge to livestock. Studies have demonstrated that HS reduces fertility and leads gut microbiota dysbiosis in bulls. However, the impact of on bulls during is still unclear. Our research revealed exposure decreased semen quality bulls, fecal transplantation (FMT) from heat-stressed recipient mice resulted significant decrease number testicular germ cells epididymal sperm. Untargeted metabolomics methodology 16S rDNA sequencing conjoint analysis Akkermansia muciniphila (A. muciniphila) seemed be key bacterial regulator spermatogenesis after exposure. Moreover, indicated A. regulated secondary bile acid metabolism by promoting colonization salt hydrolase (BSH)-metabolizing bacteria, leading increase retinol absorption host subsequently elevation retinoic level, thereby improving spermatogenesis. This study sheds light relationship between HS-induced spermatogenesis, offering potential therapeutic approach for addressing bull spermatogenic dysfunction triggered

Язык: Английский

Процитировано

11
Comparative characterization of flavor precursors and volatiles of Taihe black-boned silky fowl and Hy-line Brown yolks using multiomics and GC-O-MS-based volatilomics DOI

Weifang Yang,

Youyou Yang, Liang Wang

и другие.

Food Research International, Год журнала: 2023, Номер 172, С. 113168 - 113168

Опубликована: Июнь 18, 2023

Язык: Английский

Процитировано

23
A Comprehensive Overview of the Neural Mechanisms of Light Therapy DOI Creative Commons
Xiaodan Huang, Qian Tao, Chaoran Ren

и другие.

Neuroscience Bulletin, Год журнала: 2023, Номер 40(3), С. 350 - 362

Опубликована: Авг. 9, 2023

Abstract Light is a powerful environmental factor influencing diverse brain functions. Clinical evidence supports the beneficial effect of light therapy on several diseases, including depression, cognitive dysfunction, chronic pain, and sleep disorders. However, precise mechanisms underlying effects are still not well understood. In this review, we critically evaluate current clinical showing diseases. addition, introduce research progress regarding neural circuit modulatory functions, mood, memory, pain perception, sleep, circadian rhythm, development, metabolism.

Язык: Английский

Процитировано

22
The impact of aging and oxidative stress in metabolic and nervous system disorders: programmed cell death and molecular signal transduction crosstalk DOI Creative Commons
Kenneth Maiese

Frontiers in Immunology, Год журнала: 2023, Номер 14

Опубликована: Ноя. 8, 2023

Life expectancy is increasing throughout the world and coincides with a rise in non-communicable diseases (NCDs), especially for metabolic disease that includes diabetes mellitus (DM) neurodegenerative disorders. The debilitating effects of disorders influence entire body significantly affect nervous system impacting greater than one billion people disability peripheral as well cognitive loss, now seventh leading cause death worldwide. Metabolic disorders, such DM, neurologic remain significant challenge treatment care individuals since present therapies may limit symptoms but do not halt overall progression. These clinical challenges to address interplay between warrant innovative strategies can focus upon underlying mechanisms aging-related oxidative stress, cell senescence, death. Programmed pathways involve autophagy, apoptosis, ferroptosis, pyroptosis play critical role oversee processes include insulin resistance, β-cell function, mitochondrial integrity, reactive oxygen species release, inflammatory activation. silent mating type information regulation 2 homolog 1

Язык: Английский

Процитировано

20
A pharynx-to-brain axis controls pharyngeal inflammation–induced anxiety DOI Creative Commons

Wan Zhao,

Ke Zhang, Wanying Dong

и другие.

Proceedings of the National Academy of Sciences, Год журнала: 2024, Номер 121(11)

Опубликована: Март 6, 2024

Anxiety is a remarkably common condition among patients with pharyngitis, but the relationship between these disorders has received little research attention, and underlying neural mechanisms remain unknown. Here, we show that densely innervated pharynx transmits signals induced by pharyngeal inflammation to glossopharyngeal vagal sensory neurons of nodose/jugular/petrosal (NJP) superganglia in mice. Specifically, NJP project norepinephrinergic nucleus solitary tract (NTS NE ). These NTS ventral bed stria terminalis (vBNST) induces anxiety-like behaviors murine model inflammation. Inhibiting this pharynx→NJP→NTS →vBNST circuit can alleviate associated This study thus defines pharynx-to-brain axis mechanistically links emotional response.

Язык: Английский

Процитировано

7