Theranostics,
Год журнала:
2024,
Номер
15(4), С. 1496 - 1523
Опубликована: Дек. 31, 2024
The
human
body
is
an
intricate
system,
where
diverse
and
complex
signaling
among
different
organs
sustains
physiological
activities.
eye,
as
a
primary
organ
for
information
acquisition,
not
only
plays
crucial
role
in
visual
perception
but
also,
increasing
evidence
suggests,
exerts
broad
influence
on
the
entire
through
circuits
upon
receiving
light
signals
which
called
non-image-forming
vision.
However,
extent
mechanisms
of
light's
impact
eyes
remain
insufficiently
explored.
There
also
dearth
comprehensive
reviews
elucidating
interplay
between
light,
systemic
connections
to
body.
Herein,
we
propose
concept
light-eye-body
axis
systematically
encapsulate
extensive
effects
received
by
retina
We
reviewed
visual-neural
structure
basis
axis,
summarized
mechanism
regulate
whole
current
research
status
challenges
within
pathological
processes
involved
axis.
Future
should
aim
expand
explore
its
deeper
mechanisms.
Understanding
investigating
will
contribute
improving
lighting
conditions
optimize
health
guide
establishment
phototherapy
standards
clinical
practice.
World Journal of Meta-Analysis,
Год журнала:
2025,
Номер
13(1)
Опубликована: Март 14, 2025
BACKGROUND
Pharmacological
treatments
are
commonly
used
in
individuals
experiencing
perinatal
depression
(PPD);
however,
a
debate
regarding
the
reproductive
safety
of
antidepressants
is
ongoing.
Many
pregnant
women
opt
to
discontinue
antidepressant
out
concern
about
potential
negative
effects
on
developing
fetus,
while
slow
and
ineffective
medications
hinder
improved
outcomes
with
PPD.
In
recent
years,
bright
light
therapy
(BLT)
has
gained
traction
as
treatment
option
for
PPD;
clinical
trials
findings
examining
efficacy
BLT
this
population
have
been
inconclusive.
AIM
To
validate
feasibility
METHODS
We
performed
meta-analysis
randomized
controlled
patients
PPD
treated
vs
placebo
following
Preferred
Reporting
Items
Systematic
Reviews
Meta-Analysis.
searched
PubMed,
Embase,
Cochrane
Library,
Web
Science
studies
published
up
December
2023.
The
results
were
evaluated
using
standardized
mean
difference
improvement
scores
odds
ratios
(ORs)
remission
rate,
response
incidence
adverse
events,
dropout
rate.
RESULTS
group
had
higher
rate
[50.68%
33.08%;
OR
=
2.05;
95%
confidence
interval
(CI):
1.25-3.35;
P
0.004;
I
²
35%]
(54.10%
18.52%;
5.00;
95%CI:
2.09-11.99;
0.0003;
0%)
than
group.
Improvements
overall
(standardized
-0.47;
-0.80
-0.13;
0.007).
No
significant
differences
between
two
groups
drop-outs
(21.84%
29.63%;
0.63;
0.31-1.29;
0.21;
or
events
(17.89%
9.68%;
2.01;
0.95-4.25;
0.07;
observed.
CONCLUSION
can
potentially
treat
PPD,
showing
better
control
study.
effective
safe
could
increase
available
therapeutic
options
Cell Reports,
Год журнала:
2024,
Номер
43(6), С. 114356 - 114356
Опубликована: Июнь 1, 2024
In
addition
to
its
role
in
vision,
light
also
serves
non-image-forming
visual
functions.
Despite
clinical
evidence
suggesting
the
antipruritic
effects
of
bright
treatment,
circuit
mechanisms
underlying
on
itch-related
behaviors
remain
poorly
understood.
this
study,
we
demonstrate
that
treatment
reduces
mice
through
a
related
lateral
parabrachial
nucleus
(LPBN).
Specifically,
subset
retinal
ganglion
cells
(RGCs)
innervates
GABAergic
neurons
ventral
geniculate
and
intergeniculate
leaflet
(vLGN/IGL),
which
subsequently
inhibit
CaMKIIα+
LPBN.
Activation
both
vLGN/IGL-projecting
RGCs
vLGN/IGL-to-LPBN
projections
is
sufficient
reduce
induced
by
various
pruritogens.
Importantly,
rely
activation
retina-vLGN/IGL-LPBN
pathway.
Collectively,
our
findings
elucidate
LPBN
underlies
treatment.
Sleep Medicine,
Год журнала:
2024,
Номер
121, С. 171 - 178
Опубликована: Июль 4, 2024
To
explore
the
longitudinal
association
between
social-jetlag
(SJL)
and
obesity
development
among
adolescents,
sex-difference
related
modifying
factors
in
association.
