bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 26, 2024
ABSTRACT
The
ability
to
observe
the
social
behavior
of
others
and
use
observed
information
bias
future
action
is
a
fundamental
building
block
cognition
1,2
.
A
foundational
question
whether
observation
experience
engage
common
circuit
mechanisms
that
enable
behavioral
change.
While
classic
studies
on
learning
have
shown
aggressive
behaviors
can
be
learned
through
3
,
it
remains
unclear
aggression
promotes
persistent
neural
changes
generalize
new
contexts.
Here,
directly
compare
effects
at
brain-wide
scale,
we
develop
strategy
perform
large-scale
cell-type
specific
recordings
across
subcortical
networks
for
control
learning.
We
record
longitudinally
while
animals
“train”
direct
or
observation,
then
probe
shared
differences
in
activity
novel
“hard”
context.
Using
supervised
unsupervised
methods
quantification,
detect
unique
signatures
not
present
with
no
training.
During
find
widespread
activation
mimics
generation,
critical
signals
associated
reward
threat
After
persist
into
context,
increased
similarity
dynamics
between
groups.
Network-level
modeling
reveals
core
network,
decoupling
inhibition
from
key
hypothalamic
output
region.
This
demonstrates
“experience-like”
during
recruit
plasticity
mechanism
biases
toward
adaptive
defensive
strategies
Neuron,
Год журнала:
2023,
Номер
112(5), С. 718 - 739
Опубликована: Дек. 15, 2023
Fiber
photometry
is
a
key
technique
for
characterizing
brain-behavior
relationships
in
vivo.
Initially,
it
was
primarily
used
to
report
calcium
dynamics
as
proxy
neural
activity
via
genetically
encoded
indicators.
This
generated
new
insights
into
brain
functions
including
movement,
memory,
and
motivation
at
the
level
of
defined
circuits
cell
types.
Recently,
opportunity
discovery
with
fiber
has
exploded
development
an
extensive
range
fluorescent
sensors
biomolecules
neuromodulators
peptides
that
were
previously
inaccessible
critical
advance,
combined
availability
affordable
"plug-and-play"
recording
systems,
made
monitoring
molecules
high
spatiotemporal
precision
during
behavior
highly
accessible.
However,
while
opening
exciting
avenues
research,
rapid
expansion
applications
occurred
without
coordination
or
consensus
on
best
practices.
Here,
we
provide
comprehensive
guide
help
end-users
execute,
analyze,
suitably
interpret
studies.
Science,
Год журнала:
2023,
Номер
382(6669), С. 399 - 404
Опубликована: Окт. 26, 2023
Sexual,
parental,
and
aggressive
behaviors
are
central
to
the
reproductive
success
of
individuals
species
survival
thus
supported
by
hardwired
neural
circuits.
The
behavior
control
column
(RBCC),
which
comprises
medial
preoptic
nucleus
(MPN),
ventrolateral
part
ventromedial
hypothalamus
(VMHvl),
ventral
premammillary
(PMv),
is
essential
for
all
social
behaviors.
RBCC
integrates
diverse
hormonal
metabolic
cues
adjusts
an
animal's
physical
activity,
hence
chance
encounters.
further
engages
mesolimbic
dopamine
system
maintain
interest
reinforces
actions
that
time-locked
with
We
propose
brainstem
form
a
dual-control
generating
moment-to-moment
actions.
This
Review
summarizes
recent
progress
regarding
identities
cells
their
pathways
drive
different
aspects
Cell,
Год журнала:
2023,
Номер
186(18), С. 3862 - 3881.e28
Опубликована: Авг. 1, 2023
Male
sexual
behavior
is
innate
and
rewarding.
Despite
its
centrality
to
reproduction,
a
molecularly
specified
neural
circuit
governing
male
reward
remains
be
characterized.
We
have
discovered
developmentally
wired
necessary
sufficient
for
mating.
This
connects
chemosensory
input
BNSTprTac1
neurons,
which
innervate
POATacr1
neurons
that
project
centers
regulating
motor
output
reward.
Epistasis
studies
demonstrate
are
upstream
of
BNSTprTac1-released
substance
P
following
mate
recognition
potentiates
activation
through
Tacr1
initiate
Experimental
triggers
mating,
even
in
sexually
satiated
males,
it
rewarding,
eliciting
dopamine
release
self-stimulation
these
cells.
Together,
we
uncovered
governs
the
key
aspects
behavior:
displays,
drive,
NeuroImage,
Год журнала:
2023,
Номер
279, С. 120340 - 120340
Опубликована: Авг. 22, 2023
The
hypothalamus
plays
a
crucial
role
in
regulating
sleep-wake
cycle
and
motivated
behavior.
Sleep
disturbance
is
associated
with
impairment
cognitive
affective
functions.
However,
how
hypothalamic
dysfunction
may
contribute
to
inter-related
sleep,
cognitive,
emotional
deficits
remain
unclear.We
curated
the
Human
Connectome
Project
dataset
investigated
resting
state
functional
connectivities
(rsFC)
were
sleep
dysfunction,
as
evaluated
by
Pittsburgh
Quality
Index
(PSQI),
performance,
subjective
mood
states
687
young
adults
(342
women).
Imaging
data
processed
published
routines
corrected
threshold.
We
examined
inter-relationship
amongst
rsFC,
PSQI
score,
clinical
measures
mediation
analyses.In
whole-brain
regressions
age
drinking
severity
covariates,
men
showed
higher
rsFC
right
insula
correlation
score.
No
clusters
identified
women
at
same
Both
hypothalamic-insula
score
significantly
correlated
anxiety
depression
scores
men.
Further,
analyses
that
mediated
relationship
between
anxiety/depression
symptom
bidirectionally
men.Sleep
negative
emotions
insula,
core
structure
of
interoceptive
circuits.
Notably,
anxiety-depression
altered
are
related
poor
quality.
These
findings
specific
men,
suggesting
potential
sex
differences
neural
circuits
need
be
further
investigated.
Nature,
Год журнала:
2024,
Номер
634(8035), С. 910 - 918
Опубликована: Авг. 14, 2024
Continuous
attractors
are
an
emergent
property
of
neural
population
dynamics
that
have
been
hypothesized
to
encode
continuous
variables
such
as
head
direction
and
eye
position
