iScience,
Год журнала:
2024,
Номер
27(7), С. 110296 - 110296
Опубликована: Июнь 19, 2024
The
medial
preoptic
area
(MPOA)
has
long
been
implicated
in
maternal
and
male
sexual
behavior.
Modern
neuroscience
methods
have
begun
to
reveal
the
cellular
networks
responsible,
while
also
implicating
MPOA
other
social
behaviors,
affiliative
touch,
aggression.
interactions
rely
on
input
from
conspecifics
whose
most
important
modalities
rodents
are
olfaction
somatosensation.
These
inputs
bypass
cerebral
cortex
reach
influence
function.
Hormonal
directly
act
neurons.
In
turn,
controls
responses
via
various
projections
for
reward
motor
output.
thus
emerges
as
one
of
major
brain
centers
instinctive
While
key
elements
circuits
identified,
a
synthesis
these
new
data
is
now
provided
further
studies
mechanisms
by
which
interactions.
Science,
Год журнала:
2023,
Номер
382(6669), С. 399 - 404
Опубликована: Окт. 26, 2023
Sexual,
parental,
and
aggressive
behaviors
are
central
to
the
reproductive
success
of
individuals
species
survival
thus
supported
by
hardwired
neural
circuits.
The
behavior
control
column
(RBCC),
which
comprises
medial
preoptic
nucleus
(MPN),
ventrolateral
part
ventromedial
hypothalamus
(VMHvl),
ventral
premammillary
(PMv),
is
essential
for
all
social
behaviors.
RBCC
integrates
diverse
hormonal
metabolic
cues
adjusts
an
animal's
physical
activity,
hence
chance
encounters.
further
engages
mesolimbic
dopamine
system
maintain
interest
reinforces
actions
that
time-locked
with
We
propose
brainstem
form
a
dual-control
generating
moment-to-moment
actions.
This
Review
summarizes
recent
progress
regarding
identities
cells
their
pathways
drive
different
aspects
Sociosexual
preference
is
critical
for
reproduction
and
survival.
However,
neural
mechanisms
encoding
social
decisions
on
sex
remain
unclear.
In
this
study,
we
show
that
both
male
female
mice
exhibit
but
shift
to
when
facing
survival
threats;
their
mediated
by
the
dimorphic
changes
in
excitability
of
ventral
tegmental
area
dopaminergic
(VTA
DA
)
neurons.
males,
VTA
projections
nucleus
accumbens
(NAc)
mediate
preference,
those
medial
preoptic
preference.
females,
firing-pattern
(phasic-like
versus
tonic-like)
alteration
-NAc
projection
determines
sociosexual
preferences.
These
findings
define
neurons
as
a
key
node
decision-making
reveal
sexually
circuit
underlying
The
neural
mechanisms
underlying
the
sequential
transitions
of
male
sexual
behaviors,
including
mounting,
intromission,
and
ejaculation,
remain
largely
unexplored.
Here,
we
report
that
acetylcholine
(ACh)-dopamine
(DA)
dynamics
in
ventral
shell
nucleus
accumbens
(vsNAc)
regulate
these
mice.
During
vsNAc
displays
a
unique
pattern
dual
ACh-DA
rhythms,
generated
by
reciprocal
regulation
between
ACh
DA
signaling
via
nicotinic
receptors
(nAChRs)
D2
(D2Rs).
Knockdown
choline
acetyltransferase
(ChAT)
or
D2R
diminishes
occurrence
intromission
ejaculation.
Optogenetic
manipulations
demonstrated
maintains
behaviors
suppressing
D2RvsNAc
neurons.
Moreover,
promotes
initiation
mounting
facilitates
intromission-ejaculation
transition
inducing
slowdown
rhythm.
Together,
findings
reveal
coordinated
play
critical
role
orchestrating
behaviors.
Science,
Год журнала:
2023,
Номер
382(6669), С. 388 - 394
Опубликована: Окт. 26, 2023
The
hypothalamus
(“hypo”
meaning
below,
and
“thalamus”
bed)
consists
of
regulatory
circuits
that
support
basic
life
functions
ensure
survival.
Sitting
at
the
interface
between
peripheral,
environmental,
neural
inputs,
integrates
these
sensory
inputs
to
influence
a
range
physiologies
behaviors.
Unlike
neocortex,
in
which
stereotyped
cytoarchitecture
mediates
complex
across
comparatively
small
number
neuronal
fates,
comprises
upwards
thousands
distinct
cell
types
form
redundant
yet
functionally
discrete
circuits.
With
single-cell
RNA
sequencing
studies
revealing
further
cellular
heterogeneity
modern
photonic
tools
enabling
high-resolution
dissection
circuitry,
new
era
hypothalamic
mapping
has
begun.
Here,
we
provide
general
overview
mammalian
organization,
development,
connectivity
help
welcome
newcomers
into
this
exciting
field.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 23, 2024
Abstract
Mammalian
behavior
and
physiology
undergo
dramatic
changes
in
early
life.
Young
animals
rely
on
conspecifics
to
meet
their
homeostatic
needs,
until
weaning
puberty
initiate
nutritional
independence
sex-specific
social
interactions,
respectively.
How
neuronal
populations
regulating
functions
behaviors
develop
mature
during
these
transitions
remains
unclear.
We
used
paired
transcriptomic
chromatin
accessibility
profiling
examine
the
developmental
trajectories
of
hypothalamic
preoptic
region,
where
cell
types
with
key
roles
physiological
behavioral
control
have
been
identified
1–6
.
These
data
reveal
a
remarkable
diversity
shaped
by
sex
animal,
location
or
function
corresponding
types.
identify
stages
development,
including
perinatal
emergence
differences,
postnatal
maturation
subsequent
refinement
signaling
networks,
nonlinear
transcriptional
accelerating
at
time
puberty.
assessed
development
various
sensory
mutants
find
major
role
for
vomeronasal
sensing
timing
type
maturation.
results
provide
novel
insights
into
neurons
controlling
lay
ground
examining
dynamics
Journal of Neurochemistry,
Год журнала:
2024,
Номер
168(3), С. 163 - 184
Опубликована: Янв. 30, 2024
Abstract
This
review
explores
the
evolving
landscape
of
G‐protein‐coupled
receptor
(GPCR)‐based
genetically
encoded
fluorescent
indicators
(GEFIs),
with
a
focus
on
their
development,
structural
components,
engineering
strategies,
and
applications.
We
highlight
unique
features
this
indicator
class,
emphasizing
importance
both
sensing
domain
(GPCR
structure
activation
mechanism)
reporting
(circularly
permuted
protein
(cpFP)
fluorescence
modulation).
Further,
we
discuss
approaches,
including
selection
suitable
cpFPs
expression
systems.
Additionally,
showcase
diversity
flexibility
application
by
presenting
summary
studies
where
such
were
used.
Along
all
advantages,
also
current
limitations
as
well
common
misconceptions
that
arise
when
using
these
indicators.
Finally,
future
directions
in
engineering,
strategies
for
screening
increased
throughput,
optimization
ligand‐binding
properties,
insights,
spectral
diversity.
image
Frontiers in Endocrinology,
Год журнала:
2024,
Номер
15
Опубликована: Июнь 24, 2024
Infertility
is
becoming
a
major
public
health
problem,
with
increasing
frequency
due
to
medical,
environmental
and
societal
causes.
The
increasingly
late
age
of
childbearing,
growing
exposure
endocrine
disruptors
other
reprotoxic
products,
number
medical
reproductive
dysfunctions
(endometriosis,
polycystic
ovary
syndrome,
etc.)
are
among
the
most
common
Fertility
relies
on
fine-tuned
control
both
neuroendocrine
function
behaviors,
those
critically
regulated
by
sex
steroid
hormones.
Testosterone
estradiol
exert
organizational
activational
effects
throughout
life
establish
activate
neural
circuits
underlying
function.
This
regulation
mediated
through
estrogen
receptors
(ERs)
androgen
receptor
(AR).
Estradiol
acts
mainly
via
nuclear
ERα
ERβ.
aim
this
review
summarize
genetic
studies
that
have
been
undertaken
comprehend
specific
contribution
ERβ
in
hypothalamic-pituitary-gonadal
axis
expression
including
sexual
parental
behavior.
Particular
emphasis
will
be
placed
role
these
differences.
