What Else Is Happening to the Mirror Neurons?—A Bibliometric Analysis of Mirror Neuron Research Trends and Future Directions (1996–2024)

Brain and Behavior, Год журнала: 2025, Номер 15(4)

Опубликована: Апрель 1, 2025

ABSTRACT Background Since its discovery in the late 20th century, research on mirror neurons has become a pivotal area neuroscience, linked to various cognitive and social functions. This bibliometric analysis explores trajectory, key topics, future trends field of neuron research. Methods We searched Web Science Core Collection (WoSCC) database for publications from 1996 2024 Statistical visualization analyses were performed using CiteSpace VOSviewer. Results Publication output peaked 2013 remained active. High‐impact journals such as Science, Brain, Neuron, PNAS , NeuroImage frequently feature findings system, including distribution, neural coding, roles intention understanding, affective empathy, motor learning, autism, neurological disorders. Keyword clustering reveals major directions neurostimulation, whereas burst detection underscores emerging significance brain‐computer interfaces (BCIs). Research methodologies have been evolving traditional electrophysiological recordings advanced techniques functional magnetic resonance imaging, transcranial stimulation, BCIs, highlighting dynamic, multidisciplinary progression. Conclusions study identifies areas associated with anticipates that work will integrate artificial intelligence, clinical interventions, novel neuroimaging techniques, providing new perspectives complex socio‐cognitive issues their applications both basic science practice.

Язык: Английский

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Functional diversity along the anteroposterior axis of the ventromedial hypothalamus

Journal of Neuroendocrinology, Год журнала: 2024, Номер unknown

Опубликована: Сен. 10, 2024

Abstract Innate behaviors ensure animal survival and reproductive success. Defending their territory, escaping from predators or mating with a sexual partner, are fundamental determining the ecological fitness of individuals. Remarkably, all these share common neural substrate, as they under control ventromedial hypothalamus (VMH). Decades research have contributed to understanding exquisite diversity functional ensembles underlying wide array functions that VMH carries out. These usually distributed throughout dorsoventral mediolateral axes this nucleus. However, increasing evidence is bringing attention across its anteroposterior axis. In review, we will overview our current how different within behaviors, emphasizing newly discovered roles for anterior subdivision in context conspecific self‐defense.

Язык: Английский

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Projectome-defined subtypes and modular intra-hypothalamic subnetworks of peptidergic neurons

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Май 25, 2023

Abstract The hypothalamus plays a vital role in coordinating essential neuroendocrine, autonomic, and somatomotor responses for survival reproduction. While previous studies have explored population-level projections of hypothalamic neurons, the specific innervation patterns individual axons remain unclear. To understand organization axon projections, we conducted comprehensive reconstruction single-cell projectomes from 7,180 mouse neurons expressing neuropeptides. Our analysis identified 31 distinct subtypes based on projectome-defined characteristics, with many exhibiting long-range collateral to multiple brain regions. Notably, these selectively targeted subdomains within downstream areas, either unilaterally or bilaterally. Furthermore, observed that peptidergic neuronal types encompassed subtypes, explaining their diverse functional roles. Additionally, by examining intra-hypothalamic uncovered six modular subnetworks characterized enriched intramodular connections preferences targets. This network likely contributes coordinated outputs. In summary, our projectome reveals organizational principles governing providing framework understanding neural circuit mechanisms underlying functions hypothalamus.

Язык: Английский

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Art therapy and neuroscience: evidence, limits, and myths

Frontiers in Psychology, Год журнала: 2024, Номер 15

Опубликована: Окт. 2, 2024

The evidence base for the effectiveness of art therapy continues to grow, even as a mechanistic understanding how works remains limited. One promising avenue increasing our and why is through lens neuroscience. A neuroscience-based approach provides opportunities improving neural processes that underlie complex interaction between perception, cognition, emotion behavior play out in process. Understanding therapeutic change occurs can result improved treatment better outcomes clients. However, it be tricky connect psychological theory directly responses. purposes this perspective are provide an overview current limits neurobiological concepts neuroplasticity, mirror systems, interoception applied practice, updated information about outdated still actively used clinical practice. Critical analysis scientific knowledge then guide practice support development hypothesis-based research determine primary mechanisms drive observed effects interventions.

Язык: Английский

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A small population of stress-responsive neurons in the hypothalamus-habenula circuit mediates development of depression-like behavior in mice

Neuron, Год журнала: 2024, Номер unknown

Опубликована: Окт. 1, 2024

Язык: Английский

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Estrogen Receptor β in the Lateral Septum Mediates Estrogen Regulation of Social Anxiety-like Behavior in Male Mice

Neuroscience, Год журнала: 2023, Номер 537, С. 126 - 140

Опубликована: Дек. 1, 2023

17β-estradiol (E2) regulates various forms of social behavior through the activation two types estrogen receptors, ERα and ERβ. The lateral septum (LS) is thought to be one potential target sites E2, but role played by ERβ in this brain area remains largely unknown. In present study, we first analyzed distribution with double fluorescent immunohistochemistry a transgenic mouse line which red protein (RFP) signal has been reliable marker expression. overall number ERβ-RFP-expressing cells was significantly higher (about 2.5 times) compared ERα-expressing cells. ERs different, co-expression only seen about 1.2% total ER-positive Given these distinctive patterns, examined behavioral effects site-specific knockdown each ER using viral vector-mediated small interference RNA (siRNA) techniques male mice. We found ERβ-specific alterations during interaction test, suggesting involvement ERβ-expressing LS neurons regulation anxiety interest. Further, investigated neuronal projections ERα- injecting an anterograde tracer ERα-Cre ERβ-iCre Dense expression green fluorescence (GFP) synaptic terminals observed mice areas known related modulation anxiety. These findings collectively suggest that expressed plays major estrogenic control anxiety-like behavior.

Язык: Английский

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Aggression: The dark side of mirror neurons sheds light on their functions

Current Biology, Год журнала: 2023, Номер 33(8), С. R313 - R316

Опубликована: Апрель 1, 2023

Язык: Английский

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Sex differences in androgen receptor, estrogen receptor alpha, and c-Fos co-expression with corticotropin releasing factor expressing neurons in restrained adult mice

Hormones and Behavior, Год журнала: 2023, Номер 156, С. 105448 - 105448

Опубликована: Окт. 27, 2023

Язык: Английский

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Intrinsic dynamics and neural implementation of a hypothalamic line attractor encoding an internal behavioral state

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Май 22, 2024

Summary Line attractors are emergent population dynamics hypothesized to encode continuous variables such as head direction and internal states. In mammals, direct evidence of neural implementation a line attractor has been hindered by the challenge targeting perturbations specific neurons within contributing ensembles. Estrogen receptor type 1 (Esr1)-expressing in ventrolateral subdivision ventromedial hypothalamus (VMHvl) show male mice during fighting. We that these may variation intensity an aggressive state. Here, we report also head-fixed observing aggression. exploit this finding identify perturb attractor-contributing using 2-photon calcium imaging holographic optogenetic perturbations. On-manifold demonstrate integration persistent activity intrinsic properties which drive system along attractor, while transient off-manifold reveal rapid relaxation back into attractor. Furthermore, stimulation selective functional connectivity among neurons. Intriguingly, individual differences stability were correlated with degree Mechanistic modelling indicates dense subnetwork slow neurotransmission required explain our empirical findings. Our work bridges circuit manifold paradigms, shedding light on operational behaviorally relevant mammalian

Язык: Английский

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Enhancing aggression in Henan gamecocks via augmentation of serotonergic-dopaminergic signaling and attenuation of neuroimmune response

Poultry Science, Год журнала: 2024, Номер 103(11), С. 104055 - 104055

Опубликована: Июль 2, 2024

Animal aggression is one of the most conserved behaviors. Excessive and inappropriate was a serious social concern across species. After long-term selection under strict stress conditions, Henan gamecock serves as good model for studying aggressive behavior. In this research, we constructed game chicken backcross population containing 25% Rhode Island Red (RIR), conducted brain transcriptomics serum metabolomics analyses on (HGR) through its comparison with female encounters (HGH) male birds (BGR). The study revealed that seven differential metabolites in 172 differentially expressed genes were commonly shared both HGR vs HGH BGR comparisons. They exhibited same patterns modulation gamecocks, following either < > or style. Therein, some neurological involving serotonergic dopaminergic signaling upregulated, while levels many related neuro-immune function decreased gamecock. addition, unknown specifically highly identified. These are potentially key candidates enhancing bird's aggression. Multi-omics joint analysis tyrosine metabolism neuroactive ligand-receptor interaction affected. Overall, our results propose aggressiveness gamecocks can be heightened by activation serotonergic-dopaminergic metabolic process brain, which concurrently impairs neuroimmune system. Further research needed to identify these

Язык: Английский

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