Long-term effects of SARS-CoV-2 infection on blood vessels and blood pressure – LOCHINVAR DOI
Stefanie Lip, Tran Tran, Rebecca Hanna

и другие.

Journal of Hypertension, Год журнала: 2025, Номер unknown

Опубликована: Март 31, 2025

Objective: The COVID-19 pandemic has been linked to endothelial dysfunction and renin–angiotensin–aldosterone system (RAAS) dysregulation, potentially worsening hypertension. Longitudinal studies are needed establish COVID-19's lasting effects on blood pressure (BP) function. Our objective was determine whether increases future hypertension risk by comparing BP function in nonhypertensive survivors with controls. Methods: This single-centre prospective longitudinal study included participants without history, cases being hospital-admitted controls having negative SARS-CoV-2 antibody tests. Ambulatory monitoring, flow-mediated dilatation (FMD), 6-min walk test (6MWT), quality of life (QoL) assessments were conducted at baseline 12 months. RAAS phenotyping performed baseline. Data analysis used paired t-tests multivariable regression full per-protocol datasets. Results: ( n = 97) 66) datasets 37 15 respectively. Median ages (IQR: interquartile range) 49.0 (43.0–53.5) 50.0 (42–54.0) years. Baseline parameters similar. Multivariable adjusted analyses the group showed positive had a 12-month increase mean systolic (4.57 mmHg, [95% CI –0.04 9.18], P 0.052), diastolic (4.46 mmHg [1.01 7.90], 0.012), decrease FMD (–3.15% [–6.33 0.04], 0.053) improvement 6MWT (145.6 m [49.1 242.1], 0.004) compared QoL indicated continued challenges for recovered individuals Conclusions: Persistent vascular post-COVID-19 underscore need further long-term cardiovascular disease. Clinical trial registration: https://clinicaltrials.gov/study/NCT05087290

Язык: Английский

Cardiovascular disease as part of Long COVID: a systematic review DOI
Vasiliki Tsampasian, Maria Bäck, Marco Bernardi

и другие.

European Journal of Preventive Cardiology, Год журнала: 2024, Номер unknown

Опубликована: Фев. 20, 2024

Long COVID syndrome has had a major impact on million patients' lives worldwide. The cardiovascular system is an important aspect of this multifaceted disease that may manifest in many ways. We have hereby performed narrative review order to identify the extent manifestations syndrome.

Язык: Английский

Процитировано

18
SARS-CoV-2 and the spike protein in endotheliopathy DOI Open Access
Luca Perico, Ariela Benigni, Giuseppe Remuzzi

и другие.

Trends in Microbiology, Год журнала: 2023, Номер 32(1), С. 53 - 67

Опубликована: Июнь 12, 2023

Язык: Английский

Процитировано

36
Sequential multi-omics analysis identifies clinical phenotypes and predictive biomarkers for long COVID DOI Creative Commons
Kaiming Wang,

Mobin Khoramjoo,

Karthik K. Srinivasan

и другие.

Cell Reports Medicine, Год журнала: 2023, Номер 4(11), С. 101254 - 101254

Опубликована: Окт. 26, 2023

The post-acute sequelae of COVID-19 (PASC), also known as long COVID, is often associated with debilitating symptoms and adverse multisystem consequences. We obtain plasma samples from 117 individuals during 6 months following their acute phase infection to comprehensively profile assess changes in cytokines, proteome, metabolome. Network analysis reveals sustained inflammatory response, platelet degranulation, cellular activation convalescence accompanied by dysregulation arginine biosynthesis, methionine metabolism, taurine tricarboxylic acid (TCA) cycle processes. Furthermore, we develop a prognostic model composed 20 molecules involved regulating T cell exhaustion energy metabolism that can reliably predict clinical outcomes discharge 83% accuracy an area under the curve (AUC) 0.96. Our study pertinent biological processes differ infection, it supports development specific therapies biomarkers for patients suffering COVID.

Язык: Английский

Процитировано

27
Sex differences in airway disease: estrogen and airway surface liquid dynamics DOI Creative Commons
Brian J. Harvey, Noel G. McElvaney

Biology of Sex Differences, Год журнала: 2024, Номер 15(1)

Опубликована: Июль 18, 2024

Abstract Biological sex differences exist for many airway diseases in which females have either worse or better health outcomes. Inflammatory such as cystic fibrosis (CF) and asthma display a clear male advantage post-puberty while female benefit is observed during the pre-puberty years. The influence of menstrual cycle stage pregnancy on frequency severity pulmonary exacerbations CF point to role steroid hormones, particularly estrogen, underpinning biological these diseases. There are ways by estrogen may aggravate involving disturbances surface liquid (ASL) dynamics, inappropriate hyper-immune allergenic responses, well exacerbation pathogen virulence. deleterious effect function contrasts with characterised edema pneumonia, acute respiratory distress syndrome (ARDS) COVID-19. Airway hypersecretion alveolar flooding hallmarks ARDS COVID-19, contribute morbidity mortality severe forms ASL dynamics encompasses intrinsic features thin lining fluid covering epithelium regulate mucociliary clearance (ciliary beat, height, volume, pH, viscosity, mucins, channel activating proteases) addition innate defence mechanisms (pathogen virulence, cytokines, defensins, specialised pro-resolution lipid mediators, metabolism). Estrogen regulation contributing CF, COVID-19 major focus this review. Graphical

Язык: Английский

Процитировано

8
The effect of microbiome therapy on COVID-19-induced gut dysbiosis: A narrative and systematic review DOI Creative Commons
Mahmoud Yousef,

Mlaak Rob,

Sanish Varghese

и другие.

Life Sciences, Год журнала: 2024, Номер 342, С. 122535 - 122535

Опубликована: Фев. 24, 2024

Emerging evidence highlights the role of COVID-19 in instigating gut dysbiosis, with repercussions on disease severity and bidirectional gut-organ communication involving lung, heart, brain, liver. This study aims to evaluate efficacy probiotics, prebiotics, synbiotics, fecal microbiota transplantation (FMT) addressing dysbiosis associated COVID-19, as well their impact related clinical outcomes. We systematically review 27 studies exploring different microbiome-modulating therapies: potential interventions for COVID-19. The probiotics synbiotics investigated encompassed a spectrum eight bacterial fungal genera, namely Lactobacillus, Bifidobacterium, Streptococcus, Enterococcus, Pediococcus, Bacillus, Saccharomyces, Kluyveromyces. Noteworthy prebiotics employed these included chestnut tannin, galactooligosaccharides, fructooligosaccharides, xylooligosaccharide, resistant dextrin. majority biotics exhibited positive effects patients, manifesting symptom alleviation, inflammation reduction, notable decreases mortality rates. Five reported death rates, showing an average ranging from 0 % 11 intervention groups, compared 3 30 control groups. Specifically, demonstrated diminishing duration symptoms while significantly accelerating viral symptomatic remission. FMT emerged particularly effective strategy, successfully restoring ameliorating gastrointestinal disorders. insights gleaned this contribute our broader comprehension therapeutic COVID-19-related mitigating secondary multi-organ complications.

Язык: Английский

Процитировано

7
Diabetes Mellitus, Energy Metabolism, and COVID-19 DOI Creative Commons
Caterina Conte, Elisa Cipponeri, Michael Roden

и другие.

Endocrine Reviews, Год журнала: 2023, Номер 45(2), С. 281 - 308

Опубликована: Ноя. 2, 2023

Abstract Obesity, diabetes mellitus (mostly type 2), and COVID-19 show mutual interactions because they are not only risk factors for both acute chronic manifestations, but also alters energy metabolism. Such metabolic alterations can lead to dysglycemia long-lasting effects. Thus, the pandemic has potential a further rise of pandemic. This review outlines how preexisting spanning from excess visceral adipose tissue hyperglycemia overt may exacerbate severity. We summarize different effects SARS-CoV-2 infection on key organs tissues orchestrating metabolism, including tissue, liver, skeletal muscle, pancreas. Last, we provide an integrative view derangements that occur during COVID-19. Altogether, this allows better understanding occurring when fire starts small flame, thereby help reducing impact

Язык: Английский

Процитировано

16
Gender Differences in Response to COVID-19 Infection and Vaccination DOI Creative Commons
Kawther Zaher, Fatemah Basingab, Jehan Alrahimi

и другие.

Biomedicines, Год журнала: 2023, Номер 11(6), С. 1677 - 1677

Опубликована: Июнь 9, 2023

Since COVID-19 first appeared, a number of follow-up events have taken place. In an effort to find solution this catastrophe, great deal study and analysis has been conducted. Because the high morbidity exceptionally large losses, scientists are being pushed conduct more research vaccination treatments. The virus wide range effects, one which is how it affects sexual activity in both men women. impact cardiovascular system susceptibility embolism, lung stress, infection heightens probability hospitalization intensive care unit for pregnant women who contracted COVID-19. There no evidence passed from mother child. current review, role on male female activity, hormones, menstrual cycle females, as well sex hormones during after vaccination, investigated. reports isolated semen infected patient or recently recovered patients. A recent investigation influence gender organs function uncovered throughout study.

Язык: Английский

Процитировано

15
Emerging roles of SARS-CoV-2 Spike-ACE2 in immune evasion and pathogenesis DOI Creative Commons
Cosima T. Baldari, Anna Onnis, Emanuele Andreano

и другие.

Trends in Immunology, Год журнала: 2023, Номер 44(6), С. 424 - 434

Опубликована: Апрель 6, 2023

The COVID-19 pandemic, caused by SARS-CoV-2, has an estimated 5 billion infections and 20 million deaths respiratory failure. In addition to the disease, SARS-CoV-2 infection been associated with many extrapulmonary complications not easily explainable infection. A recent study showed that spike protein, which mediates cell entry binding angiotensin-converting enzyme 2 (ACE2) receptor, signals through ACE2 change host behavior. CD8+ T cells, spike-dependent ACE2-mediated signaling suppresses immunological synapse (IS) formation impairs their killing ability, leading immune escape of virus-infected cells. this opinion article, we discuss consequences on response propose it contributes manifestations COVID-19.

Язык: Английский

Процитировано

14
Oligosaccharides as Potential Regulators of Gut Microbiota and Intestinal Health in Post-COVID-19 Management DOI Creative Commons
Kit‐Leong Cheong, Shutong Chen, Bo Teng

и другие.

Pharmaceuticals, Год журнала: 2023, Номер 16(6), С. 860 - 860

Опубликована: Июнь 9, 2023

The COVID-19 pandemic has had a profound impact worldwide, resulting in long-term health effects for many individuals. Recently, as more and people recover from COVID-19, there is an increasing need to identify effective management strategies post-COVID-19 syndrome, which may include diarrhea, fatigue, chronic inflammation. Oligosaccharides derived natural resources have been shown prebiotic effects, emerging evidence suggests that they also immunomodulatory anti-inflammatory could be particularly relevant mitigating the of COVID-19. In this review, we explore potential oligosaccharides regulators gut microbiota intestinal management. We discuss complex interactions between microbiota, their functional metabolites, such short-chain fatty acids, immune system, highlighting improve manage syndrome. Furthermore, review with angiotensin-converting enzyme 2 expression alleviating Therefore, offer safe, natural, approach potentially improving health, overall outcomes

Язык: Английский

Процитировано

14
Discovery of highly potent covalent SARS-CoV-2 3CLpro inhibitors bearing 2-sulfoxyl-1,3,4-oxadiazole scaffold for combating COVID-19 DOI

Fu-Mao Zhang,

Ting Huang, Feng Wang

и другие.

European Journal of Medicinal Chemistry, Год журнала: 2023, Номер 260, С. 115721 - 115721

Опубликована: Авг. 17, 2023

Язык: Английский

Процитировано

13