The Nephron journals/Nephron journals, Год журнала: 2024, Номер unknown, С. 1 - 27
Опубликована: Окт. 15, 2024
Sex differences exist in kidney physiology and disease which are underpinned by the biological actions of sex hormones estrogen, progesterone testosterone. In this review, we present an up-to-date discussion hormonal molecular signalling pathways implicated health disease.
Язык: Английский
medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown
Опубликована: Янв. 14, 2025
Abstract Introduction Pulmonary exacerbations contribute to disease progression in chronic lung diseases. In a large prospective cohort study, we studied the incidence and predictors of pulmonary among persons with primary ciliary dyskinesia (PCD), which can inform follow-up care. We also assessed healthcare use, changes management, pathogens during exacerbations. Methods Participants Living PCD study reported increased respiratory symptoms past seven days, indicating exacerbation, from June 2020 through May 2022 via online questionnaires. derived rates exacerbation by fitting multivariable negative binomial regression models. Results obtained data 660 (408 adults, 57 adolescents, 195 children) who completed 17,853 questionnaires (median 17, range 1-84). The 1026 indicate an rate 3.1 per person year, minor variation across age groups, but over time. Incidence was higher adult females [incidence ratio (IRR) 2.0, 95% confidence interval (CI) 1.4-2.7] those whom Pseudomonas aeruginosa isolated (children IRR 1.9, CI 1.1-3.6; adults 1.4, 1.0-1.9). saw health professional only 185 1404 weeks (13%). pathogen most frequently observed children (18 118 samples, 15%) (132 303 44%). Conclusion are frequent heighten burden. Patients for targeted management is particularly important include carry .
Язык: Английский
Процитировано
1
BMC Public Health, Год журнала: 2024, Номер 24(1)
Опубликована: Окт. 21, 2024
Reliable estimates of asthma prevalence are essential for developing effective public health policies. However, discrepancies in published results have posed challenges planning China. To address this issue, we conducted study to provide a comprehensive assessment the epidemiology We thorough systematic review across multiple databases including PubMed, Embase, Web Science, China National Knowledge Infrastructure (CNKI), Wanfang Data, and Weipu database. The search was limited studies either Chinese or English up August 31, 2023, that reported on extracted relevant characteristics performed meta-analyses. protocol registered with PROSPERO (CRD42023397949). A literature yielded 192 met inclusion criteria out 17,152 articles. overall Mainland found be 2.20% (95% confidence interval, CI: 1.96-2.47%; I2 = 99.8%), ever at 2.21%, current 2.16%, asthma-like symptoms 14.36%, 3.01%. Using random-effects model, prediction interval ranged from 0.44 10.27%. Meta-analysis subgroups indicated men children elderly generally higher asthma. In addition, is urban areas East has been rise over past three decades, 0.69% 1984 5.30% 2021. Projections suggest could reach 9.76% by 2050 population. Asthma remains less prevalent than western countries, however its gradually increasing thirty years. disease burden shows notable variations based sex, age, geographic regions, indicating significant demographic regional disparities. guide decision-making priorities direct future research, conducting high-quality epidemiological crucial.
Язык: Английский
Процитировано
4
BMC Pulmonary Medicine, Год журнала: 2025, Номер 25(1)
Опубликована: Янв. 14, 2025
Lung health is intricately linked with inflammation. The pan-immune-inflammation value (PIV) emerges as a promising biomarker, offering reflection into systemic inflammatory states and assisting in the prognosis of diverse diseases. This research aims to explore associations between PIV respiratory symptoms, diseases lung function. study was cross-sectional population from National Health Nutrition Examination Survey (NHANES). Restricted cubic spline (RCS) models were conducted relationships outcomes, while weighted linear regression logistic ones used for analysis. Trend tests probed evolving relationship among quartiles outcomes. incorporated subgroup analysis interaction examine within specific subpopulations. From cohort 6,263 participants, distinct negative correlation identified health. Subsequent confounding factors, 100-unit increment 2% increase incidence cough phlegm (OR, 95% CI: 1.02, 1.00 1.05; 1.04). Additionally, higher associated reductions FEV1 (MD, -5.37, -9.10 -1.64) FVC -5.75, -10.34 -1.15). Categorizing revealed an ascending trend: A significantly risk cough/phlegm/wheeze found participants second/third/fourth quartile compared those first (all p trend < 0.05). Moreover, function indicators (FEV1, FEV1%, FVC, FVC%, FEV1/FVC) declined fourth Besides, nonlinear outcomes evident. Subgroup variations these stratified by gender, age, smoking drinking status, well certain disease history. highlighted potential connections Monitoring level could provide valuable insights status may inform clinical approaches managing
Язык: Английский
Процитировано
0
Infection, Год журнала: 2025, Номер unknown
Опубликована: Янв. 30, 2025
Abstract Background Lung transplantation is the ultimate treatment option for patients with advanced cystic fibrosis. Chronic colonization of these recipients multidrug-resistant (MDR) pathogens may constitute a risk factor an adverse outcome. We sought to analyze whether MDR pathogens, as outlined in German classification multiresistant Gram-negative bacteria (MRGN), was associated success lung transplantation. Methods performed monocentric retrospective analysis 361 transplantations Homburg, Germany, between 1995 and 2020. All main diagnosis fibrosis ( n = 69) were stratified into two groups based on Pseudomonas aeruginosa view MRGN before transplantation: no without 23) or 46) resistance three four antibiotic (3MRGN/4MRGN). Multivariable analyses including various clinical parameters (preoperative data, postoperative data). Results CF colonized ) classified 3MRGN/4MRGN had poorer survival (median 16 years (without MRGN) versus 8 (with MRGN), P 0.048). Extracorporeal support 0.014, HR 2.929), re-transplantation 0.023, 2.303), female sex 0.019, 2.244) 0.036, 2.376) predictors poor outcomes multivariate analysis. Co-colonization mold Aspergillus fumigatus further mortality group 0.037, 2.150). Conclusion Patients are candidates transplantation, targeted diagnostics tailored anti-infective strategies essential after surgery. expressed by help identify at increased improve organ allocation process.
Язык: Английский
Процитировано
0
Frontiers in Nutrition, Год журнала: 2025, Номер 12
Опубликована: Март 21, 2025
Background Asthma, a chronic respiratory disease, is influenced by diet, which plays key role in its onset and progression. The Children’s Dietary Inflammatory Index (C-DII) measures how diets impact inflammation children adolescents (6–19 years). C-DII metric that quantifies the inflammatory potential of with higher scores indicating more pro-inflammatory scoring range from −6.25 to 6.02. This study investigates association between asthma prevalence US adolescents. Methods Data National Health Nutrition Examination Survey (NHANES) 2013–2018 2021–2023 were utilized. participants aged 6–19 years who completed dietary interviews provided asthma-related information was included. calculated using 24-h recall data, data categorized into quartiles. Asthma diagnosis based on self-reported doctor current status. Multivariable logistic regression, smooth curve fitting, threshold benefit analysis, Restricted Cubic Spline (RCS) analyses performed evaluate relationship prevalence. Results 6,523 analyzed. median score was-0.026, 18.63%. A U-shaped observed prevalence, lowest risk at of-0.99. Subgroup revealed variability across demographic groups. Age-based analysis indicated significant interaction ( p = 0.047), weakest 17–19 age group. Ethnicity showed differences, particularly Mexican-American (OR 0.83, 95% CI: 0.70–0.97) Non-Hispanic Black 1.56, 1.36–1.80) subgroups. Conclusion underscores non-linear adolescents, emphasizing importance balanced patterns mitigating risk. Future longitudinal studies are warranted confirm these findings explore causal pathways.
Язык: Английский
Процитировано
0
Journal of Clinical Medicine, Год журнала: 2025, Номер 14(8), С. 2603 - 2603
Опубликована: Апрель 10, 2025
Background: This study aimed to develop a scoring system that predicts postoperative oxygen requirements, enhances clinical decision-making, reduces unnecessary use, and improves the efficiency of respiratory care. Methods: retrospective included patients who underwent elective non-cardiac surgery with general anesthesia between 1 January 2018 31 December 2022. The outcome was requirement at PACU discharge. Predictors significance were used create system. Results: Among 42,378 cases, 14.9% required supplemental WHO2SAFE score, which ranges from 0 15, incorporates eight independent risk factors, given in mnemonic WHO2SAFE: intraoperative wheezing, hypotension, obesity, operative time ≥ 180 min, sleep apnea, ASA classification 3, female, elderly. Conclusions: score provides practical tool for predicting need discharge via web, facilitating early intervention efficient resource utilization. A cutoff 6 facilitates clinicians identify high-risk benefit close observation while minimizing use low-risk individuals.
Язык: Английский
Процитировано
0
Pharmacophore, Год журнала: 2024, Номер 15(3), С. 34 - 40
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
0
The Nephron journals/Nephron journals, Год журнала: 2024, Номер unknown, С. 1 - 27
Опубликована: Окт. 15, 2024
Sex differences exist in kidney physiology and disease which are underpinned by the biological actions of sex hormones estrogen, progesterone testosterone. In this review, we present an up-to-date discussion hormonal molecular signalling pathways implicated health disease.
Язык: Английский
Процитировано
0