Molecular Basis of Cancer

Опубликована: Окт. 4, 2024

Язык: Английский

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Enhancing immuno-oncology investigations through multidimensional decoding of tumor microenvironment with IOBR 2.0

Cell Reports Methods, Год журнала: 2024, Номер unknown, С. 100910 - 100910

Опубликована: Дек. 1, 2024

Язык: Английский

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Pan-cancer integrative analyses dissect the remodeling of endothelial cells in human cancers

National Science Review, Год журнала: 2024, Номер 11(9)

Опубликована: Июль 10, 2024

ABSTRACT Therapeutics targeting tumor endothelial cells (TECs) have been explored for decades, with only suboptimal efficacy achieved, partly due to an insufficient understanding of the TEC heterogeneity across cancer patients. We integrated single-cell RNA-seq data 575 patients from 19 solid types, comprehensively charting phenotypic diversities. Our analyses uncovered underappreciated compositional and functional in TECs a pan-cancer perspective. Two subsets, CXCR4+ tip SELE+ veins, represented prominent angiogenic proinflammatory phenotypes TECs, respectively. They exhibited distinct spatial organization patterns, compared adjacent non-tumor tissues, tissue showed increased prevalence cells, yet veins depleted. Such characteristics underlie their differential associations response anti-angiogenic therapies immunotherapies. integrative resources findings open new avenues understand clinically intervene vasculature.

Язык: Английский

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Design, synthesis, and anticancer evaluation of N-sulfonylpiperidines as potential VEGFR-2 inhibitors, apoptotic inducers

Bioorganic Chemistry, Год журнала: 2024, Номер 145, С. 107157 - 107157

Опубликована: Фев. 7, 2024

Язык: Английский

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Integrated miRNA and mRNA omics reveal neferine induced autophagy- dependent ferroptosis in human endometrial cancer in vivo and in vitro

Food Bioscience, Год журнала: 2024, Номер unknown, С. 105243 - 105243

Опубликована: Окт. 1, 2024

Язык: Английский

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From Images to Genes: Radiogenomics Based on Artificial Intelligence to Achieve Non‐Invasive Precision Medicine in Cancer Patients

Advanced Science, Год журнала: 2024, Номер 12(2)

Опубликована: Ноя. 13, 2024

Abstract With the increasing demand for precision medicine in cancer patients, radiogenomics emerges as a promising frontier. Radiogenomics is originally defined methodology associating gene expression information from high‐throughput technologies with imaging phenotypes. However, advancements medical imaging, omics technologies, and artificial intelligence, both concept application of have significantly broadened. In this review, history enumerated, related five basic workflows their applications across tumors, role AI radiogenomics, opportunities challenges tumor heterogeneity, immune microenvironment. The positron emission tomography multi‐omics studies also discussed. Finally, faced by clinical transformation, along future trends field

Язык: Английский

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Advances in multi-omics studies of microvascular invasion in hepatocellular carcinoma

European journal of medical research, Год журнала: 2025, Номер 30(1)

Опубликована: Март 13, 2025

Microvascular invasion (MVI) represents a pivotal independent prognostic factor for the recurrence of hepatocellular carcinoma (HCC) after surgery. It contributes to early intervention potentially recurrent HCC enhance patient outcomes and increase survival rates. Traditionally, diagnosis MVI has relied on postoperative pathological analysis, accurate preoperative detection methodologies are lacking. Recent research suggests that multi-omics strategies play role in definitively diagnosing before surgery offering personalized selection clinical decision-making management. This review meticulously examines approach prediction patients, aiming innovate diagnostic paradigms anticipate postsurgical recurrence, thereby facilitating earlier more therapeutic strategies.

Язык: Английский

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Spatial relationships and interactions of immune cell niches are linked to the pathologic response of muscle-invasive bladder cancer to neoadjuvant therapy

Journal of Translational Medicine, Год журнала: 2025, Номер 23(1)

Опубликована: Март 27, 2025

The identification of the complex spatial architecture immune cell infiltration and its interaction mechanisms within tumor ecosystems provides crucial insights into therapeutic responses to neoadjuvant therapy in muscle-invasive bladder cancer (MIBC). This study aims characterize features distinct cell-type niches microenvironment (TME) patients with varying therapy. We performed transcriptomic profiling on six MIBC specimens obtained from a registered clinical trial (ChiCTR2000032359), generating whole-transcriptome atlases map TME architecture. High-throughput analytical frameworks were employed deconstruct TME, key findings validated through immunohistochemistry mouse model experiments. Our analysis revealed that tissues complete responders exhibited greater T B cells, formation tertiary lymphoid structure (TLS). Trajectory identified CCL19/CCL21 as signaling molecules driving TLS MIBC. Mouse experiments demonstrated recombinant protein injections promoted intratumoral enhance efficacy immunotherapy. Furthermore, we observed significant intrinsic heterogeneity individual tumors, which may contribute lack underscores critical role response drivers tumors potential immune-sensitizing agents. Additionally, should be considered factor influencing efficacy.

Язык: Английский

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Advances and applications of multiomics technologies in precision diagnosis and treatment for gastric cancer

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Год журнала: 2025, Номер unknown, С. 189336 - 189336

Опубликована: Апрель 1, 2025

Язык: Английский

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Discovery of 4-(N-dithiobenzyl piperazine)-1,8-naphthalimide as a potent multi-target antitumor agent with good efficacy, limited toxicity, and low resistance

European Journal of Medicinal Chemistry, Год журнала: 2023, Номер 263, С. 115937 - 115937

Опубликована: Ноя. 10, 2023

Язык: Английский

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